Vorwort und allgemeiner Bauplan

Kolmer, W.; Lauber, H.

doi:10.1007/978-3-662-21655-2_1

Cited by 1 publication

(1 citation statement)

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“…Along these lines, Müller cells in the developing fovea are postulated to provide a tractional force capable of shaping its cellular architecture during morphogenesis and, in the postnatal fovea, changing its morphology in response to light. [42][43][44] Regional differences in cell proliferation are another potential source of mechanical force in developing tissues. Unbalanced cell proliferation, especially in the context of adjacent, interacting tissues with different biomechanical properties, can cause the bending of tissues and has been implicated in the formation of the optic cup and neural tube.…”

Section: Relationship Between Changes In Ocular Shape Retinal Differe...mentioning

confidence: 99%

Dynamic changes in ocular shape during human development and its implications for retina fovea formation

Rasys,

Wegerski,

Trainor

et al. 2023

BioEssays

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The human fovea is known for its distinctive pit‐like appearance, which results from the displacement of retinal layers superficial to the photoreceptors cells. The photoreceptors are found at high density within the foveal region but not the surrounding retina. Efforts to elucidate the mechanisms responsible for these unique features have ruled out cell death as an explanation for pit formation and changes in cell proliferation as the cause of increased photoreceptor density. These findings have led to speculation that mechanical forces acting within and on the retina during development underly the formation of foveal architecture. Here we review eye morphogenesis and retinal remodeling in human embryonic development. Our meta‐analysis of the literature suggests that fovea formation is a protracted process involving dynamic changes in ocular shape that start early and continue throughout most of human embryonic development. From these observations, we propose a new model for fovea development.

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Section: Relationship Between Changes In Ocular Shape Retinal Differe...mentioning

confidence: 99%