Twelve site models were established based on the analysis of the influence of site conditions on earthquake damage and the influence of the soft soil layer on-site seismic response. The equivalent linearization site seismic response analysis is carried out at different input ground motion levels to discuss the influence of soft soil layer thickness and buried depth. The results show that the characteristic period of the response spectrum exhibits a gradual increase as the buried depth or thickness of the soft soil layer increases. Furthermore, the characteristic period of the response spectrum also increases with the rise in the input ground motion peak. Moreover, according to the influence characteristics of soft soil thickness, buried depth, and input ground motion intensity on the characteristic period of the site acceleration response spectrum, a method for adjusting the characteristic period of the site acceleration response spectrum with a soft soil layer is put forward.