Vulvar granular cell tumor

Sönmez, Fatma Cavide; Köroğlu, Nadiye; Guler, Beril; Arıcı, Dilek Sema

doi:10.4103/0377-4929.188134

Cited by 9 publications

(17 citation statements)

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“…A wide spectrum of mesenchymal tumors can occur in the vulva and vagina of adults. As for prepubertal patients, the relative frequency of these tumors has not been precisely reported since such tumors are extremely rare in young girls [14].…”

Section: Discussionmentioning

confidence: 99%

Schwannoma of the clitoris: a case report

Kocak¹,

Selam²,

Akar³

et al. 2021

European Journal of Gynaecological Oncology

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Schwannoma (neurilemoma or neurinoma) is a tumor that develops from the Schwann cells in the myelin sheath of the peripheral nerves. It is most commonly observed on the head, neck, upper and lower extremities, posterior mediastinum and retroperitoneum. Schwannomas are rarely found in the external female genitalia. To the best of our knowledge, only 6 cases of clitoral schwannoma have been reported in medical literature. We currently report the case of a 46-year-old woman who was presenting with a 3 × 2 cm, painless mass in her clitoris for the past two years. She has no history of neurofibromatosis. Surgical excision of the mass was undertaken. Histopathology and immunohistochemistry revealed schwannoma of the clitoris. No evidence of local recurrence was noted a ter 6 months of follow-up. We are reporting the current patient because of the rare location of schwannoma. In the present case report, clinical features, treatment guidelines, diagnostic features and the immunohistochemical characteristics of this tumor are reviewed.

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Section: Discussionmentioning

confidence: 99%

Schwannoma of the clitoris: a case report

Kocak¹,

Selam²,

Akar³

et al. 2021

European Journal of Gynaecological Oncology

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“…Granular cell tumour has been reported to occur in the soft tissues of the head, neck and other regions of the body including the larynx [4], suprasellar space [5], nasal septum [6], oral mucosa [7], mediastinum [8], buttock [9], vulva [10], back [11], rectum [12], etc. Granular cell tumour of the breast is rare and only a few case series have been studied so far [2].…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

Presentation of a Case Report and Literature Review on Granular Cell Tumour of the Breast

Vhriterhire

Ngbea

Gyenger

et al. 2020

JAMMR

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A 21 years old woman presented with a breast swelling of 4 years duration and with an associated pain of a more recent onset. On clinical examination, the mass was found to be firm, mobile and without attachment to the skin or surrounding structures. An excisional biopsy was performed based on a provisional clinical diagnosis of fibroadenoma. However, histological evaluation showed the tumour to be a granular cell tumour. The clinical features of this rare tumour may mimic a variety of conditions and cause a diagnostic dilemma.

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“…Granular cell tumours (GCTs) are uncommon skin and soft tissue lesions [1] which make up less than 0.1 percent of surgical specimens and only 0.5 to 1.3 percent of soft tissue tumours [2,3]. These tumours are thought to be of nerve sheath origin, likely Schwann cells [4,5].…”

Section: Introductionmentioning

confidence: 99%

“…They are typically located in the head and neck region, predominantly the oral cavity [6]. Gynaecological locations are uncommon; vulvar lesions represent 5 to 16 percent of such tumours [7,8] however, cervical, ovarian [3] and clitoral location [9] have been reported. They most commonly affect women in their 40s to 60s [3].…”

Section: Introductionmentioning

confidence: 99%

“…Gynaecological locations are uncommon; vulvar lesions represent 5 to 16 percent of such tumours [7,8] however, cervical, ovarian [3] and clitoral location [9] have been reported. They most commonly affect women in their 40s to 60s [3]. Familial inheritance occurs such as in Noonan syndrome, but this is an extremely rare phenomenon [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Vulvar granular cell tumour in a recently post-partum woman: a case report

2022

European Journal of Gynaecological Oncology

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Granular cell tumours (GCTs) are uncommon neuroectodermally derived tumours. Vulvar location is rare with 134 reported cases presenting as a non-specific vulvar mass. They are of low malignant potential and management is local excision. They have a high local recurrence rate if incompletely excised. The GCT diagnosis is often retrospective due to its rarity, its non-specific presenting symptoms and numerous differentials. Here we descibe the case of a 31-year-old woman presenting after an asymptomatic right labium majus mass was noted during a postnatal visit. This was imaged with magentic resonance imaging (MRI) and a biopsy was inconclusive. She was referred for subspecialty consultation at the Chris O’Brien Lifehouse. The lesion was five centimetres, overlying the pubis and inferolateral to the clitoris with no skin changes or epidermal attachment. Wide local excision was performed. Histopathology showed GCT features with no malignant characteristics, but positive margins. Despite positive margins, the decision was made to not complete re-excision and observe for recurrence. This was an unusual case in a young postpartum woman. It highlights the need for clinical suspicion of this tumour type during a postpartum examination and the need for nuanced decision making regarding re-excision based on individual patient needs despite recurrence risk.

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Vulvar granular cell tumor

Cited by 9 publications

References 0 publications

Schwannoma of the clitoris: a case report

Schwannoma of the clitoris: a case report

Presentation of a Case Report and Literature Review on Granular Cell Tumour of the Breast

Vulvar granular cell tumour in a recently post-partum woman: a case report

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