Vulvar sarcoma: A report of four cases

Bakri, Younes N.; Akhtar, Mohammed; El-Senoussi, Mohamed; Wierzbicki, Ryszard

doi:10.1016/0090-8258(92)90238-e

Cited by 16 publications

(8 citation statements)

References 5 publications

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“…Leiomyosarcoma is the most common histologic variant of vulvar sarcoma; it is relatively more common in the reproductive years ( 1,2 ) . The natural history of vulvar sarcoma is not clearly understood; this is related to the rarity of the vulvar involvement by primary sarcomatous neoplasms, various histologic types, and the limited number of case reports ( 3,6 ) . Moreover, as most reported cases had short‐term follow‐up it is difficult to draw meaningful conclusions ( 3 ) .…”

Section: Discussionmentioning

confidence: 99%

“…Bakri et al . ( 6 ) reported a 41‐year‐old patient who died of disease 108 months after wide local excision of a vulvar leiomyosarcoma. In Tavassoli and Norris's series seven patients with leiomyomas were pregnant at the time of diagnosis, and all the tumors had grown noticeably during gestation.…”

Section: Discussionmentioning

confidence: 99%

“…Leiomyosarcoma is the most common histologic variant of vulvar sarcoma; in addition liposarcomas, neurofibrosarcomas, angiosarcomas, and epithelioid sarcomas have also been reported ( 3,4 ) . Because of its rarity, our knowledge of the disease has been limited to sporadic case reports and small reviews rather than large series ( 1–10 ) .…”

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confidence: 99%

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Rapid growth of myxoid leiomyosarcoma of the vulva during pregnancy: a case report

Gilio¹,

Cormio²,

Resta³

et al. 2004

Int J Gynecol Cancer

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Smooth muscle tumors arising in the vulva are rare. Leiomyosarcoma is the most common variant of vulvar sarcoma, and very few cases have been reported during pregnancy. A 36-year-old woman presented with a progressively enlarging vulvar mass during pregnancy, diagnosed as a Bartholin's gland cyst. The lesion was resected at 38 weeks of gestation during cesarean section and diagnosis of myxoid leiomyosarcoma of the vulva was made. Six weeks later the patients were referred to our center and submitted to wide vulvar excision with groin lymph node dissection that revealed the presence of a small residual focus of leiomyosarcoma. At 30 months of follow-up the patient was well without any sign of recurrent disease. Leiomyosarcoma should be included in the differential diagnosis of vulvar masses; progressively enlarging vulvar lesion should be biopsied even during pregnancy. Leiomyosarcoma should be considered in the differential diagnosis of vulvar mass.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Rapid growth of myxoid leiomyosarcoma of the vulva during pregnancy: a case report

Gilio¹,

Cormio²,

Resta³

et al. 2004

Int J Gynecol Cancer

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“…The relatively young mean age of the initial presentation (Table 1) may lead one to think that sarcoma of the vulva is a disease of reproductive years. There were few cases reported in pregnancy ( 7,8 ) . Strong estrogen receptor positivity of tumor cells was also reported ( 4 ) .…”

Section: Discussionmentioning

confidence: 99%

Soft tissue sarcoma of the vulva: A clinical study

Ulutin

Zellars

Frassica

2003

Int J Gynecol Cancer

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The purpose of this study is to report clinical aspects and treatment results of patients seen at Johns Hopkins. A search of the tumor registry of the Sidney Kimmel Comprehensive Cancer Center found 453 patients with malignancies of the vulva registered between 1977 and 1997. Patient and tumor characteristics, treatment methods, and follow-up were obtained from charts. Seven patients were identified with sarcoma of the vulva. Of these, one was removed from analysis due to histology. Three patients had leiomyosarcoma, two had fibrosarcoma, and one had epithelioid sarcoma. The mean age was 41. Mean time to diagnosis was 6 months. All but one of the tumors was located on the labia majora. Median tumor size was 3.5 cm. Surgery varied from wide local excision to radical vulvectomy with inguinal lymph node dissection. Surgical margins were microscopically negative in five of the six cases. Two patients had received adjuvant external beam radiation. One of them had a tumor greater than 5 cm and close surgical margins and the other had high-grade tumor, which recurred after previous surgery. Mean follow-up was 127.8 months. There have been no recurrences to date.

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“…This hypothesis is supported by the findings of coexistence between vulvar leiomyosarcomas and longstanding lichen sclerosus (28). Also, another predisposing factor of vulvar leiomyosarcomas seems to be the pregnancy because occurrence of them during pregnancy has been reported (10,17,29). It seems that the positivity of estrogen and progesterone receptors is implicated in the development of vulvar leiomyosarcomas.…”

Section: Introductionmentioning

confidence: 70%

Primary vulvar leiomyosarcoma localized in the Bartholin's gland area: A case report and review

et al. 2021

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Vulvar sarcomas located in the Bartholin's gland area are extremely uncommon mesenchymal vulvar tumors. These neoplasms can be mistaken as Bartholin' gland benign lesions such as cysts or abscesses, leading to a delay in the diagnosis of underlying malignancy. Currently, only a few cases of these aggressive cancers have been reported in the literature. A 42-year-old female patient without any previous complaint presented to Obstetrics and Gynecology Department of 'G. Chaztikosta' General Hospital due to a vulvar lump in the area of the left Bartholin's gland with a 6-month history of progressive swelling. Pelvic examination showed a solid mass of 6.5-cm in maximum diameter, localized in the left Bartholin's gland. The patient underwent wide local excision and histopathological examination of hematoxylin and eosin-stained sections indicated intersecting fascicles of spindle cells, with moderate to severe atypia. The number of mitoses was up to 8 per 10 high power fields. The neoplasm to its greatest extent was circumscribed and in places had an invasive growth pattern. Tumoral necrosis was not seen. Involved Bartholin' gland by the tumor was identified. The tumor extended focally to the surgical margin. The neoplastic cells showed positive staining for smooth muscle actin, desmin, HHF35, caldesmon, vimentin and estrogen and progesterone receptors. Immunohistochemistry was negative for S100, myoglobulin, keratin 116, CD117, CD34 and CD31. The patient denied further surgery or/and local radiotherapy, although the mass was >5-cm and a focally infiltrative surgical margin was found. During the close follow-up, no local recurrences or metastases were observed 53 months after surgery. In conclusion, wide local tumor excision with free surgical margins is a good option of surgery for vulvar leiomyosarcomas. In recurrences, a new extensive surgical resection of the lesion and radiotherapy are suggested. Ipsilateral lympadenectomy is indicated when there is a pathologic lymph node. Chemotherapy is provided in cases of distal metastases.

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Vulvar sarcoma: A report of four cases

Cited by 16 publications

References 5 publications

Rapid growth of myxoid leiomyosarcoma of the vulva during pregnancy: a case report

Rapid growth of myxoid leiomyosarcoma of the vulva during pregnancy: a case report

Soft tissue sarcoma of the vulva: A clinical study

Primary vulvar leiomyosarcoma localized in the Bartholin's gland area: A case report and review

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