Wachstumshormon und Knochen

Wilhelm, Beate; Kann, Peter Herbert

doi:10.1007/s00063-004-1088-4

Cited by 12 publications

(1 citation statement)

References 49 publications

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“…Compounds 5 (Aescin, a drug widely used in Europe) and 13 Aescin, the major active principle from the horse chestnut tree, has previously been used to treat patients with chronic venous insufficiency (30,31), hemorrhoids (32), postoperative edema (30,32), and inflammatory action (30,33). Reserpine, a naturally occurring alkaloid produced by several members of the genus Rauwolfia, has been used primarily as a peripheral antihypertensive and as a central depressant and sedative (34).…”

Section: Inhibition Of Viral Replication Tested By Elisa Western Blomentioning

confidence: 99%

Small molecules targeting severe acute respiratory syndrome human coronavirus

Jan

Hwa

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

493

416

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Severe acute respiratory syndrome (SARS) is an infectious disease caused by a novel human coronavirus. Currently, no effective antiviral agents exist against this type of virus. A cell-based assay, with SARS virus and Vero E6 cells, was developed to screen existing drugs, natural products, and synthetic compounds to identify effective anti-SARS agents. Of >10,000 agents tested, Ϸ50 compounds were found active at 10 M; among these compounds, two are existing drugs (Reserpine 13 and Aescin 5) and several are in clinical development. These 50 active compounds were tested again, and compounds 2-6, 10, and 13 showed active at 3 M. The 50% inhibitory concentrations for the inhibition of viral replication (EC50) and host growth (CC50) were then measured and the selectivity index (SI ‫؍‬ CC50͞EC50) was determined. The EC50, based on ELISA, and SI for Reserpine, Aescim, and Valinomycin are 3.4 M (SI ‫؍‬ 7.3), 6.0 M (SI ‫؍‬ 2.5), and 0.85 M (SI ‫؍‬ 80), respectively. Additional studies were carried out to further understand the mode of action of some active compounds, including ELISA, Western blot analysis, immunofluorescence and flow cytometry assays, and inhibition against the 3CL protease and viral entry. Of particular interest are the two anti-HIV agents, one as an entry blocker and the other as a 3CL protease inhibitor (Ki ‫؍‬ 0.6 M).

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Section: Inhibition Of Viral Replication Tested By Elisa Western Blomentioning

confidence: 99%

Small molecules targeting severe acute respiratory syndrome human coronavirus

Jan

Hwa

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

493

416

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Structure and Function of Bone Marrow Adipocytes

Paula

Rosen

2017

Comprehensive Physiology

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Adipocytes are heterogeneous cells strongly linked to energy storage and disposal. In parallel, adipocytes are endowed with an extensive portfolio of endocrine molecules, whose secretion varies depending on nutritional status. Marrow adipose tissue (MAT) has specific characteristics that are not shared by white (WAT) or brown (BAT) adipose tissue. First, marrow adipocytes and osteoblasts are terminally differentiated cells that originate from the same bone marrow mesenchymal stromal cell. Differently from WAT adipocytes, marrow adipocytes expand under conditions of energy restriction and seem to be not influenced by energy surplus, at least in humans. Over the last few years, several lines of evidence have suggested that bone cells and MAT are mutually connected regarding the modulation of both energy metabolism and bone remodeling. Adipokines (e.g., adiponectin, leptin, and chemerin), incretins (GLP1 and GIP), and several classical hormones (e.g., GH and insulin) are biochemical components involved in the modulation of bone remodeling, marrow adipogenesis, and energy metabolism. As expected, metabolic and nutritional diseases such as diabetes mellitus and anorexia nervosa (AN) greatly affect MAT quantity and quality as well as bone strength. Although the interest in MAT started recently, the rapid advances in current technology have expedited unprecedented growth of knowledge in this area. The present review intends to give to the reader an up-to-date perspective about MAT structure and physiology as well as its involvement in metabolic and nutritional diseases such as diabetes mellitus and ano-rexia. © 2018 American Physiological Society. Compr Physiol 8:315-349, 2018.

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Osteoporose

2018

Fachwissen Osteologie

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Wachstumshormon und Knochen

Cited by 12 publications

References 49 publications

Small molecules targeting severe acute respiratory syndrome human coronavirus

Small molecules targeting severe acute respiratory syndrome human coronavirus

Structure and Function of Bone Marrow Adipocytes

Osteoporose

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