Wall Shear Stress Directional Abnormalities in BAV Aortas: Toward a New Hemodynamic Predictor of Aortopathy?

Grewal, Nimrat; Groot, Adriana C. Gittenberger‐de

doi:10.3389/fphys.2019.00225

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…Outside the scope of the work, other clinical areas were left, in which the study of biomechanical factors is progressing very actively and contributes to the translation of the results of these studies into clinical practice. So, it should be noted that there is great importance of research on biomechanical factors in the development and progression of vascular aneurysms and aortopathies [ 78 , 79 ].…”

Section: Diagnostic Methods For Assessing Bio-mechanical Forces In Vivo and Clinical Implicationsmentioning

confidence: 99%

Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment

Генкель

Kuznetcova

Шапошник

2020

CCR

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: The article provides an overview of current views on the role of biomechanical forces in the pathogenesis of atherosclerosis. The importance of biomechanical forces in maintaining vascular homeostasis is considered. We provide descriptions of mechanosensing and mechanotransduction. The roles of wall shear stress and circumferential wall stress in the initiation, progression and destabilization of atherosclerotic plaque are described. The data on the possibilities of assessing biomechanical factors in clinical practice and the clinical significance of this approach are presented. The article concludes with discussion current therapeutic approaches based on the modulation of biomechanical forces.

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Section: Diagnostic Methods For Assessing Bio-mechanical Forces In Vivo and Clinical Implicationsmentioning

confidence: 99%

Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment

Генкель

Kuznetcova

Шапошник

2020

CCR

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“…Disturbance of aortic hemodynamics leads to non-uniform WSS, which is considered one of the mechanisms leading to BAV aortopathy and local aortic wall lesions ( Grewal and Gittenberger-De Groot, 2019 ). Flow pattern and local WSS distribution in the aorta were changed in BAV patients without aortic aneurysm or even with normal valve function ( Hope et al, 2010 ; Garcia et al, 2016 ).…”

Section: Hemodynamicsmentioning

confidence: 99%

Aortic Dilatation in Patients With Bicuspid Aortic Valve

et al. 2021

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Bicuspid aortic valve (BAV) is the most common congenital cardiac abnormality. BAV aortic dilatation is associated with an increased risk of adverse aortic events and represents a potentially lethal disease and hence a considerable medical burden. BAV with aortic dilatation warrants frequent monitoring, and elective surgical intervention is the only effective method to prevent dissection or rupture. The predictive value of the aortic diameter is known to be limited. The aortic diameter is presently still the main reference standard for surgical intervention owing to the lack of a comprehensive understanding of BAV aortopathy progression. This article provides a brief comprehensive review of the current knowledge on BAV aortopathy regarding clinical definitions, epidemiology, natural course, and pathophysiology, as well as hemodynamic and clinically significant aspects on the basis of the limited data available.

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Wall Shear Stress Directional Abnormalities in BAV Aortas: Toward a New Hemodynamic Predictor of Aortopathy?

Cited by 2 publications

References 26 publications

Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment

Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment

Aortic Dilatation in Patients With Bicuspid Aortic Valve

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