Warm Haemolysins Active against Trypsinized Red Cells; Occurrence, Inheritance, and Clinical Significance

Studies on Naturally Occurring Warm Haemolysins and Haemagglutinins Active against Trypsinized Red Cells

“…A normal serum with haemolytic and agglutinating activity against trypsintreated red blood cells at 37 °C has been studied. The properties of this serum appear to be very similar, if not identical, to those of the warm haemolysin described by Heist0 et al [1].…”

“…Heist0 et al [1] have described the occurrence of a warm haemolysin (and haemagglutinin) active against trypsinized normal red blood cells (TRC) in sera of a high proportion of healthy people. The distribution of the warm haemolysin between the two sexes and in families suggested that it was part of a genetic polymorphism, controlled by genes on the X chromosome.…”

Studies on the Agglutinin Accompanying the Warm Haemolysin Active against Trypsinized Red Cells

“…6 as seen in tables I and IV. The first demonstration of this agglutinin in a previous study [1], and the finding that its titre was often higher than that of the haemolysin, made us hopeful that the test for the agglutinin might be more sensitive than the test for the haemolysin. However, the findings in the present study clearly demonstrate that there is no parallel ism between the results of the test for the warm haemolysin and the agglutinin.…”

“…The methods used in the present study are the same as those used in 3 previous papers [1][2][3]. The trypsin treatment was performed in principle according to the technique recommended by Pickles [4].…”

“…In a previous paper [1] attention was drawn to the fact that the warm haemolysin active against trypsin treated red cells are often accompanied by an agglutinin active at 37 °C. This agglutinin has several peculiarities:…”