This paper proposes an integrated life cycle assessment-life cycle cost (LCA-LCC) model of environmental and economic factors for highway engineering technical schemes to problems such as the limitations of single-dimensional assessment, their narrow scope, the difficulty in tracing sources, and the conflicts of various dimensions in existing integrated assessment methods. The latest documents issued by the Ministry of Ecology and Environment and the Ministry of Transport of China used as an integrated assessment database. Air pollution, water pollution, solid waste pollution, noise pollution, energy consumption, pre-project cost, project construction cost, project operation cost, and post-project cost were used to construct the integrated assessment index system of environmental and economic factors. An improved entropy method was adopted in the LCA-LCC model to overcome the problems of ambiguous results of the previous entropy due to too few assessment schemes, the inoperability of the method when it encounters a negative value or zero value, and unbalanced multi-angle assessments. This model was applied to the assessment of two asphalt pavement maintenance schemes of Highway US280 in Alabama and two improvement schemes of high liquid limit soil subgrade of Highway G360 in Hainan. The results show that the LCA-LCC model overcomes the limitations and imbalances of a single LCA or LCC. The gravel improved scheme and the cold recycling scheme were identified through quantitative assessment as more sustainable. This paper can provide a reference for the comprehensive quantitative assessment of environmental and economic benefits of highway engineering technical schemes.