Wart, Keratoacanthoma, and Squamous Cell Carcinoma: A Spectrum of the Same Neoplastic Process?

Ledo, Elena

doi:10.1111/j.1365-4362.1992.tb04240.x

Cited by 10 publications

(7 citation statements)

References 15 publications

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“…If KA are truly able to form metastasis is still a matter of debate, in contrast with SCC which metastasize in up to 5% (83,84). As reported, these metastasizing KA could have been misdiagnosed as KA but are true SCC (5,8,69,76,78,(85)(86)(87). In fact 10% as KA diagnosed tumors are malignant and progressing SCC (9,69).…”

Section: Regressionmentioning

confidence: 98%

Keratoacanthoma: a distinct entity?

Gleich

Chiticariu

Huber

et al. 2015

Experimental Dermatology

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Keratoacanthoma (KA) are common but exceptional benign tumors, often appearing on sun-exposed areas of light skinned people and showing spontaneous resolution. The goal of this study was to review existing literature, to point out the etiological complexity of KA biology and to answer the controversial debate if or not KA is a distinct entity or a variant of squamous cell carcinoma (SCC). Relying on recent results, we highlight that KA is an individual lesion with a unique molecular signature caused by alterations in the TGFb signalling pathway. These recent findings will help to understand the nature of KA and to develop new reliable diagnostic tools, simplifying the discrimination of the histologically similar KA and SCC.

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Section: Regressionmentioning

confidence: 98%

Keratoacanthoma: a distinct entity?

Gleich

Chiticariu

Huber

et al. 2015

Experimental Dermatology

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“…18,22 Other reports propose that similar to actinic keratoses, KAs may belong to a spectrum of premalignant lesions that can transform into SCCs over time. 23 Overall, many still consider the two lesions as distinct entities whose overlapping features lead to common diagnostic confusion. [24][25][26][27] To date, studies to definitively separate the two neoplasms based on histopathology, biomarkers, and biochemical or genetic studies have not been successful.…”

Section: Discussionmentioning

confidence: 99%

Sorafenib‐induced premalignant and malignant skin lesions

Williams

Cohen

2011

Int J Dermatology

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The possibility of rapidly developing actinic keratoses, keratocanthomas, verrucas, and SCC during treatment with sorafenib, warrants close dermatologic follow-up and a lower threshold for biopsy and treatment of suspicious cutaneous lesions. Development of a sorafenib-induced SCC is not an absolute contraindication for continued use of sorafenib therapy; however, the drug should be briefly discontinued until lesions are treated.

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“…Similarly, Kern et al [15] showed that there are histological criteria which make it possible to differentiate between these two lesions in 80% of cases. Recently, Fujisawa et al [16] and Ledo [17] pointed out the usefulness of a flow cytometric method which measures the nucleus DNA content to distinguish between KA and SCC. Recently, Fujisawa et al [16] and Ledo [17] pointed out the usefulness of a flow cytometric method which measures the nucleus DNA content to distinguish between KA and SCC.…”

Section: Histologymentioning

confidence: 99%

“…The difficulty remains, however, that other authors try from the outset to include KA under the heading of lowmalignancy SCC [9]. Recently, Fujisawa et al [16] and Ledo [17] pointed out the usefulness of a flow cytometric method which measures the nucleus DNA content to distinguish between KA and SCC. Yet other authors mention the value of quantifying protein PSIOO [18], the value of keratinocyte differentiation markers [19], or the value of calculating the number of elastic fibres present in lesions [20].…”

Section: Histologymentioning

confidence: 99%

Multinodular keratoacanthoma and T cell lymphoma

Vanhooteghem

Wiart

Creusy

et al. 1996

Acad Dermatol Venereol

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This is a report of a case of multinodular keratoacanthoma (MNKA), a rare variety of solitary keratoacanthoma (KA) characterized by a collection of multiple KA nodules on the margins of a necrotic ulcerative lesion spreading centrifugally for 3 weeks in a patient with malignant non-Hodgkin's T-cell lymphoma. The very infiltrative nature of the main lesion made differential diagnosis difficuh in the presence of extremely differentiated squamous cell carcinoma (SCC). Later, a KA lesion was to appear opposite a cutaneous lymphoma. The authors discuss the close links between the MNKA and the KA lesions and the immunosuppressed state of the patient.Elsevier Science B.V. SSDl 0926-9959(95)00095-X

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Wart, Keratoacanthoma, and Squamous Cell Carcinoma: A Spectrum of the Same Neoplastic Process?

Cited by 10 publications

References 15 publications

Keratoacanthoma: a distinct entity?

Keratoacanthoma: a distinct entity?

Sorafenib‐induced premalignant and malignant skin lesions

Multinodular keratoacanthoma and T cell lymphoma

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