Waste-minimized, solvent-free and continuous flow synthesis of α-ketoamides from aryl methyl ketones using recyclable CuBr2 catalyst, via bromo intermediate
“…The continuous flow process also facilitates the reaction with reduced catalyst loading in comparison to the corresponding batch process. 28 Our lab is working on the development of new synthetic methods using a flow reactor. 29 We attempted to study the α-amination of esters using a CuBr 2 catalyst, as part of our lab's current ongoing research on the development of Cu-catalysed synthetic methods and synthesis of APIs.…”
Copper (II) bromide/N-methylmorpholine N-oxide (NMO) promoted α-amination of esters under continuous-flow conditions with reduced catalyst loading is reported. The α-amino esters are precursors for α-amino acids. This method provides α-amino...
“…The continuous flow process also facilitates the reaction with reduced catalyst loading in comparison to the corresponding batch process. 28 Our lab is working on the development of new synthetic methods using a flow reactor. 29 We attempted to study the α-amination of esters using a CuBr 2 catalyst, as part of our lab's current ongoing research on the development of Cu-catalysed synthetic methods and synthesis of APIs.…”
Copper (II) bromide/N-methylmorpholine N-oxide (NMO) promoted α-amination of esters under continuous-flow conditions with reduced catalyst loading is reported. The α-amino esters are precursors for α-amino acids. This method provides α-amino...
“…Flow chemistry is considered as a green technology for the safe handling of hazardous materials, unstable intermediates, and the reduction of waste and time of reaction. 34,35 We anticipated that continuous-flow conditions may help in maintaining an excellent inert atmosphere and reducing the molecular oxygen mediated oxidation of selenols. The commercial Vaportec R series flow reactor containing fluorinated ethylene propylene (FEP) tubing (volume: 10 mL) was used.…”
A new metal-free method for the synthesis of selenoesters directly from carboxylic acids in a flow reactor is reported. The carboxylic acids, Michael acceptors, bifunctional selenoureas (source of selenium and...
A photocatalyzed one-pot borylation of haloarene and reduction of aldehyde by cocatalysis of bis(pinacoloto)diboran/4-phenyl pyridine is reported. The reaction was carried out in a flow reactor by irradiating the reaction at 410nm, with residence time of 10 min. The method was successfully applied for the synthesis of tavaborole in a single step with 81% yield.
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