Wastewater sequencing as a powerful tool to reveal SARS-CoV-2 variant introduction and spread in French Guiana, South America

Combe, Marine; Cherif, Emira; Deremarque, Théo; Rivera-Ingraham, Georgina; Seck-Thiam, Fatou; Justy, Fabienne; Doudou, Jean-Claude; Carod, Jean-François; Carage, Thierry; Procureur, Angélique; Gozlan, Rodolphe Elie

doi:10.1016/j.scitotenv.2024.171645

Cited by 1 publication

(1 citation statement)

References 94 publications

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“…The use of wastewater monitoring can provide a comprehensive approach to tracking the circulation and spread of different SARS-CoV-2 variants within a community or population (Bartel et al, 2024;Combe et al, 2024;Cutrupi et al, 2022;Espinosa-Gongora et al, 2023;Lipponen et al, 2024). This method provides a broader perspective beyond individual testing, offering insights into the overall viral landscape and aiding in the early detection of emerging variants (Sapoval et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Tracking the Spread of the BA.2.86 Lineage in Italy Through Wastewater Analysis

Veneri,

Brandtner,

Mancini

et al. 2024

Food Environ Virol

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The emergence of new SARS-CoV-2 variants poses challenges to global surveillance efforts, necessitating swift actions in their detection, evaluation, and management. Among the most recent variants, Omicron BA.2.86 and its sub-lineages have gained attention due to their potential immune evasion properties. This study describes the development of a digital PCR assay for the rapid detection of BA.2.86 and its descendant lineages, in wastewater samples. By using this assay, we analyzed wastewater samples collected in Italy from September 2023 to January 2024. Our analysis revealed the presence of BA.2.86 lineages already in October 2023 with a minimal detection rate of 2% which then rapidly increased, becoming dominant by January 2024, accounting for a prevalence of 62%. The findings emphasize the significance of wastewater-based surveillance in tracking emerging variants and underscore the efficacy of targeted digital PCR assays for environmental monitoring.

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