Water Activity in Aqueous Solution of Sucrose in the Presence of Some Deep Eutectic Solvents

Abstract

In this work, the effect of some deep eutectic solvents (DESs) based on choline chloride on water activity (a w ) in aqueous solutions of sucrose was investigated. Activity of water (a w ) and vapor pressure data are obtained precisely using an improved isopiestic technique and correlated with Wilson, e-NRTL, UNIQUAC, and simple polynomial empirical models. The e-NRTL model was successfully employed to calculate the activity coefficient and Gibbs free energies of transfer of sucrose from water to aqueous DES solutions. The results show that the strong interactions between sucrose and the DES are favorable. Also, the Hansen solubility parameters were calculated to predict an appropriate solvent system. The Gibbs free energy results indicate that the salting-in effect is greater in the presence of glycerol-based DES.

Osmotic Coefficients of Gabapentin Drug in Aqueous Solutions of Deep Eutectic Solvents: Experimental Measurements and Thermodynamic Modeling

“…The osmotic coefficients of solutions containing drugs, especially in the presence of DESs with VPO, have not been reported in the literature, and this is the first work in this field. However, studies have been performed on the vapor–liquid equilibrium of systems including DESs as well as drugs alone and in the presence of sugars or amino acids, and their calculations determine the osmotic coefficients that are an important quantity in showing the behavior and related interactions between components. − The advantages of this method can be accurate measurements, less time-consuming, sufficient small quantities, and saving materials (drugs and DES), which is an expensive component compared to organic solvents. In contrast, in other methods such as isopiestic, the equilibrium time is high and some substances, especially drugs, are destroyed.…”