Water Dynamics in Competitive Solvation Assisted Loading of Colloidal Curcumin Nanoparticles onto Mesoporous Silica Nanostructures

Abstract

The main goal of this study is to develop methods for the simultaneous synthesis and loading of curcumin nanoparticles onto mesoporous silica by a sequential solvent evaporation approach. It is known that the presence of cosolvents and surfactants facilitates the homogenous formation of colloidal curcumin nanoparticles and enhances loading into mesoporous silica nanoparticles. The stability of the curcumin nanoparticles and their substantial loading are characterized as a function of the mesoporous silica nanostructures (MSN) surface properties, allowing to put into evidence how the dielectric nanoenvironment, largely determined by the water dynamics in the presence of cosolvents and of surfactants, plays a crucial role in the micelle mediated loading of curcumin nanoparticles into the mesoporous silica nanostructure. The interfacial hydrogen bonded corrugated network with its occupational electronic distribution shields the curcumin nanoparticles loaded onto the MSNs. Highly monodispersed nanostructures that are obtained that exhibit redox behavior, Fickian diffusion following linear compensation effect, and increased ionic activity triggered in an acidic pH ambiance. The augmented bioactivity of the human acute monocyte leukemia cancer cell line U937 elects the synthesized curcumin nanoparticles @ MSNs as a suitable nanostructure against acidic tumor microenvironment.

Mussel-inspired HA@TA-CS/SA biomimetic 3D printed scaffolds with antibacterial activity for bone repair

“…Acidic inflammatory environments protonate chitosan in the scaffold and form more amide bonds with sodium alginate, leading to tighter binding, slower degradation and more sustained drug release during scaffold degradation. The composite of curcumin with mesoporous material might restrict curcumin in monomorphic form within the spaces of a porous material ( Ananth et al, 2022 ). In this way, the solubility and bioavailability of curcumin could be significantly improved.…”

“…In vitro cell assay is an essential tool to detect growth inhibition, functional changes, cell lysis, death, or other toxic reactions of cells after exposure to biological materials in an isolated environment that simulates the growth environment of an organism ( Ananth et al, 2022 ; Claro et al, 2023 ). The cell viability of BMSCs cultured in DMON@Cur-loaded HA@TA-CS/SA scaffold extracts assayed by the CCK-8 method is demonstrated in Figure 11A .…”

Advanced Biomaterials and 3D Printing Technologies in Bone Repair

“…In vitro cell assay is an essential tool to detect growth inhibition, functional changes, cell lysis, death, or other toxic reactions of cells after exposure to biological materials in an isolated environment that simulates the growth environment of Frontiers in Bioengineering and Biotechnology frontiersin.org an organism (Ananth et al, 2022;Claro et al, 2023). The cell viability of BMSCs cultured in DMON@Cur-loaded HA@TA-CS/SA scaffold extracts assayed by the CCK-8 method is demonstrated in Figure 11A.…”