Water-electrolyte metabolism, renal function, and cutaneous microcirculation in human subjects during a seven-day dry immersion

Ларина, И. М.; Cousteau, M. A.; Пастушкова, Л. Х.; Vasilieva, G. Yu.; Dobrokhotov, I. V.; Istomina, V E

doi:10.1134/s0362119710070157

Cited by 4 publications

(5 citation statements)

References 11 publications

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“…Hemoconcentration during dry immersion is reflected by an increase in the levels of erythrocytes (Kozinets et al 1983;Navasiolava et al 2010a), hemoglobin (Kozinets et al 1983;Larina et al 2008;Navasiolava et al 2010a) and hematocrit (Fomin 1981;Gogolev et al 1980;Iarullin et al 1987;Larina et al 2008;Navasiolava et al 2010a;Pakharukova et al 2009a) (Fig. 7), although all these values remain within physiological limits.…”

Section: Red Blood Cellsmentioning

confidence: 93%

“…Following an initial decrease (approximately -15% within the first day of dry immersion) (Leach Huntoon et al 1998), plasma volume remains stable thereafter (Gogolev et al 1980;Larina et al 2008;Navasiolava et al 2010b;Nesterovskaia et al 2008;Pakharukova et al 2009a). During head-down bed rest, plasma volume decreases by approximately 10%, and this also occurs mainly within the first 24 h (Greenleaf et al 1977;Pavy-Le Traon et al 2007) (Fig.…”

Section: Plasma Volume and Fluid Compartmentsmentioning

confidence: 95%

“…Larina et al (2008) have reported a weight decrease of appproximately 2 kg, or 3%, by the end of a 7-day period of dry immersion. Dry immersion always induces weight loss, mainly due to increased fluid loss, and also through decreased fluid intake due to diminished thirst (Grigor'ev and Shul'zhenko 1979).…”

Section: Weight Changesmentioning

confidence: 96%

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Long-term dry immersion: review and prospects

et al. 2010

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Dry immersion, which is a ground-based model of prolonged conditions of microgravity, is widely used in Russia but is less well known elsewhere. Dry immersion involves immersing the subject in thermoneutral water covered with an elastic waterproof fabric. As a result, the immersed subject, who is freely suspended in the water mass, remains dry. For a relatively short duration, the model can faithfully reproduce most physiological effects of actual microgravity, including centralization of body fluids, support unloading, and hypokinesia. Unlike bed rest, dry immersion provides a unique opportunity to study the physiological effects of the lack of a supporting structure for the body (a phenomenon we call 'supportlessness'). In this review, we attempt to provide a detailed description of dry immersion. The main sections of the paper discuss the changes induced by long-term dry immersion in the neuromuscular and sensorimotor systems, fluid-electrolyte regulation, the cardiovascular system, metabolism, blood and immunity, respiration, and thermoregulation. The long-term effects of dry immersion are compared with those of bed rest and actual space flight. The actual and potential uses of dry immersion are discussed in the context of fundamental studies and applications for medical support during space flight and terrestrial health care.

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Section: Red Blood Cellsmentioning

confidence: 93%

Section: Plasma Volume and Fluid Compartmentsmentioning

confidence: 95%

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Long-term dry immersion: review and prospects

et al. 2010

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“…Dry immersion, as well as HDBR, is accompanied by central hypervolemia, inducing an increase in cardiac dimension with heart stretching. For this reason, plasma volume decreases by approximately 15% within the first day of DI (Leach Huntoon et al, 1998) and remains stable thereafter (Gogolev et al, 1980;Larina et al, 2008;Nesterovskaia et al, 2008;Pakharukova et al, 2009;Navasiolava et al, 2011b). Decreased plasma volume is associated with diuresis and natriuresis (Epstein, 1992).…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion

et al. 2020

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Background: The most applicable human models of weightlessness are −6 • headdown bed rest (HDBR) and head-out dry immersion (DI). A detailed experimental comparison of cardiovascular responses in both models has not yet been carried out, in spite of numerous studies having been performed in each of the models separately. Objectives: We compared changes in central hemodynamics, autonomic regulation, plasma volume, and water balance induced by −6 • HDBR and DI. Methods: Eleven subjects participated in a 21-day HDBR and 12 subjects in a 3-day DI. During exposure, measurements of the water balance, blood pressure, and heart rate were performed daily. Plasma volume evolution was assessed by the Dill-Costill method. In order to assess orthostatic tolerance time (OTT), central hemodynamic responses to orthostatic stimuli, and autonomous regulation, the 80 • lower body negative pressure-tilt test was conducted before and right after both exposures. Results: For most of the studied parameters, the changes were co-directional, although they differed in their extent. The changes in systolic blood pressure and total peripheral resistance after HDBR were more pronounced than those after DI. The OTT was decreased in both groups: to 14.2 ± 3.1 min (vs. 27.9 ± 2.5 min before exposure) in the group of 21-day HDBR and to 8.7 ± 2.1 min (vs. 27.7 ± 1.2 min before exposure) in the group of 3-day DI. Conclusions: In general, cardiovascular changes during the 21-day HDBR and 3day DI were co-directional. In some cases, changes in the parameters after 3-day DI exceeded changes after the 21-day HDBR, while in other cases the opposite was true. Significantly stronger effects of DI on cardiovascular function may be due to hypovolemia and support unloading (supportlessness).

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“…The other immersion fluids can be sodium chloride or silicon with a temperature that is appropriate (34.5 °C), and the position can be standing, sitting, inverted, or horizontal. Dry immersion is certainly effective for the study of the effects of physical inactivity on skeletal muscles (muscular atrophy; Litvinova et al, ), the cardiovascular system (deconditioning syndrome; Iwase et al, ), and renal physiology (electrolyte homeostasis; Larina and Kysto, ), but it has some limitations for training during long stays in space (Navasiolava et al, ).…”

Section: Models Of Movement Restraintmentioning

confidence: 99%

Movement impairment: Focus on the brain

Adami

Bottai

2016

J of Neuroscience Research

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The saying "mens sana in corpore sano" has a particular resonance these days because, for the majority who have a very sedentary occupation, the everyday rhythms of life do not compel us to do much physical exercise. Recently published data indicate that exercise can counteract the effects of neurological diseases such as Alzheimer's disease and have prompted research on the beneficial effects of movement on the brain and brain neurogenesis. This might lead us to hypothesize that the absence or reduction of movements, especially those with antigravity effects, could induce a deterioration of the brain. This Review discusses current knowledge of the relationship between neurogenic capacity and the lack of motor activity in human and animal models.

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Water-electrolyte metabolism, renal function, and cutaneous microcirculation in human subjects during a seven-day dry immersion

Cited by 4 publications

References 11 publications

Long-term dry immersion: review and prospects

Long-term dry immersion: review and prospects

Cardiovascular System Under Simulated Weightlessness: Head-Down Bed Rest vs. Dry Immersion

Movement impairment: Focus on the brain

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