Water-soluble Ag2S quantum dots for near-infrared fluorescence imaging in vivo

Jiang, Peng; Zhu, Chunnan; Zhang, Zhiling; Tian, Zhi‐Quan; Pang, Dai‐Wen

doi:10.1016/j.biomaterials.2012.03.059

Cited by 300 publications

(228 citation statements)

References 28 publications

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“…71,72 Ag 2 S QDs terminated with a carboxylic acid group showed strong fluorescence and good photostability that is suitable for future biomedical applications. 73 Biocompatible core/shell QDs were constructed with Zn 2+ ions to address the unexpected blue-shift of CuInS 2 -based nanocrystals. The prepared QDs coupled with cyclic Arg-GlyAsp (cRGD) peptides emitted stronger signals than ZCIS/ZnS QDs in cancer detection.…”

mentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

213

149

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Near-infrared fluorescence (NIRF) imaging is an attractive modality for early cancer detection with high sensitivity and multi-detection capability. Due to convenient modification by conjugating with moieties of interests, NIRF probes are ideal candidates for cancer targeted imaging. Additionally, the combinatory application of NIRF imaging and other imaging modalities that can delineate anatomical structures extends fluorometric determination of biomedical information. Moreover, nanoparticles loaded with NIRF dyes and anticancer agents contribute to the synergistic management of cancer, which integrates the advantage of imaging and therapeutic functions to achieve the ultimate goal of simultaneous diagnosis and treatment. Appropriate probe design with targeting moieties can retain the original properties of NIRF and pharmacokinetics. In recent years, great efforts have been made to develop new NIRF probes with better photostability and strong fluorescence emission, leading to the discovery of numerous novel NIRF probes with fine photophysical properties. Some of these probes exhibit tumoricidal activities upon light radiation, which holds great promise in photothermal therapy, photodynamic therapy, and photoimmunotherapy. This review aims to provide a timely and concise update on emerging NIRF dyes and multifunctional agents. Their potential uses as agents for cancer specific imaging, lymph node mapping, and therapeutics are included. Recent advances of NIRF dyes in clinical use are also summarized.

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mentioning

confidence: 99%

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Yi¹,

Wang²,

Qin³

et al. 2014

IJN

213

149

View full text Add to dashboard Cite

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“…Their brightness [3], photostability [4], surface functionality and size-tuneable emission [5] set them apart from other fluorescent materials such as organic dyes. The physical properties can be tuned to meet specific requirements by changing the chemical composition [6,7], particle size and shape [8], surface chemistry and interfacial structures [9]. QDs can be synthesised using either organic [10] or aqueous [1,11] methods.…”

Section: Introductionmentioning

confidence: 99%

Surfactant-dependent photoluminescence of CdTe/CdS nanocrystals

Virzbickas

Rimkute

Harvie

et al. 2017

Journal of Experimental Nanoscience

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The photoluminescence of aqueously synthesised core/shell CdTe/ CdS quantum dots (QDs) was investigated. Two molar ratios (2.4 and 1.3) of thioglycolic acid (TGA) to Cd 2C were compared to determine the best synthesis conditions for high photoluminescent quantum yield (PLQY) and photostability. A difference in the PLQY of the CdTe/CdS QDs was observed when CdS shells were grown with different TGA/Cd 2C ratios. The difference in the observed PLQY was attributed to the quality of the passivation of the CdTe during the CdS shell growth. At TGA/Cd 2C ratio of 1.3, the CdS shell forms through homogeneous nucleation, which is limited by diffusion of growth material from the solution onto the QDs surface. Due to the lattice mismatch of CdTe and CdS, the core will experience coherence strain resulting in dislocation sites and surface defects between nucleation sites which can result in non-radiative trap states. When the TGA/Cd 2C ratio is 2.0, the CdS shell grows epitaxially, minimising the number of surface trap states. Finally, we observed that the fluorescence intermittency was supressed for CdTe QDs after UV light illumination, attributed to annealing of deep surface trap states by UV light.

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“…A few aqueous synthetic strategies for water-soluble NIR°uorescent Ag 2 S QDs have also been reported to avoid a further phase transfer process for bio-application. [27][28][29][30] Pang's group 27 made the¯rst attempt to synthesize water-soluble carboxylic acid group terminated Ag 2 S QDs with tunable emissions in ethylene glycol by a one-step method, and directly injected the Ag 2 S QDs with the emission at 910 nm into the subcutaneous tissue and the abdominal cavity for small animal imaging. However, previous methods for preparing water-soluble Ag 2 S QDs still require high temperature, argon gas protection and a nonaqueous solvent.…”

Section: Introductionmentioning

confidence: 99%

“…However, previous methods for preparing water-soluble Ag 2 S QDs still require high temperature, argon gas protection and a nonaqueous solvent. 27,28 Furthermore, previous applications of Ag 2 S QDs were also limited only for cell imaging 29 and nontargeted small animal imaging. 27 Therefore, it is of great interest to develop a mild and e®ective route for preparing functionalized water-soluble NIR°uor-escent Ag 2 S QDs for targeted tumor imaging in vivo.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of biocompatible near infrared fluorescence Ag₂S quantum dot and its application in bioimaging

Zhang

Chen

2014

J. Innov. Opt. Health Sci.

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Near infrared (NIR) emitting quantum dots (QDs) is a promising candidate for biomedical imaging in living tissues. However, the biomedical application of NIR QDs was not satisfactory due to their toxicity. Ag 2 S QDs was reported to have negligible toxicity in organisms. Therefore, the appropriate narrow bandgap and low toxicity of Ag 2 S QDs facilitated them to be a promising contrast agent for°uorescence imaging. Here, a low toxicity, stable and highly luminescent NIR Ag 2 S QDs were prepared by one-step aqueous method using 2-mercaptopropionic acid (MPA) as the coating layers. Emission wavelength of Ag 2 S QDs could be tuned between 780 and 950 nm. MTT assay results indicated that there was no signi¯cant biotoxicty for Ag 2 S QDs. These NIR QDs exhibited excellent biocompatibility in tumor cells. The cellular uptake and localization of Ag 2 S QDs was studied using laser confocal scanning microscopy. Ag 2 S QDs were e®ectively internalized by the cells. Therefore, Ag 2 S QDs, acting as a novel°uorescence probe, has promising potential in biolabeling, deep tissue imaging, diagnostics and photodynamic therapy.

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Water-soluble Ag2S quantum dots for near-infrared fluorescence imaging in vivo

Cited by 300 publications

References 28 publications

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Surfactant-dependent photoluminescence of CdTe/CdS nanocrystals

Synthesis of biocompatible near infrared fluorescence Ag₂S quantum dot and its application in bioimaging

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Water-soluble Ag2S quantum dots for near-infrared fluorescence imaging in vivo

Cited by 300 publications

References 28 publications

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Near-infrared fluorescent probes in cancer imaging and therapy: an emerging field

Surfactant-dependent photoluminescence of CdTe/CdS nanocrystals

Synthesis of biocompatible near infrared fluorescence Ag2S quantum dot and its application in bioimaging

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Synthesis of biocompatible near infrared fluorescence Ag₂S quantum dot and its application in bioimaging