Water soluble cyclodextrin polymers: Their interaction with drugs

Szemán, Julianna; Fenyvesi, Éva; Szejtli, J.; Ueda, Hitoshi; Machida, Yoshiharu; Nagai, Tsuneji

doi:10.1007/bf00664098

Cited by 60 publications

(32 citation statements)

References 6 publications

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“…CD‐based covalent networks and polymers were originally investigated as column material for chromatographic separations and it was shown that aromatic amino acids could be simply separated from non‐aromatic amino acids on the basis that the former forms inclusion complexes with CD . The use of these systems was further extended to high‐performance capillary electrophoresis, whereby β‐CD was covalently embedded into dextran polymer gel networks and consequently applied to the chiral separation of peptides and small ions . This ideology was further extrapolated for use within the pharmaceutical industry as drug deposits, whereby networks were fabricated through the cross‐linking of CDs with epichlorohydrin .…”

Section: Cyclodextrin‐based Hydrogel Networkmentioning

confidence: 99%

Cyclodextrin‐Based Supramolecular Assemblies and Hydrogels: Recent Advances and Future Perspectives

Tan

Ladewig

et al. 2014

Macromol. Rapid Commun.

146

115

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encompasses an array of noncovalent interactions that can yield highly complex and ordered structures. As a result of their wide availability and negligible toxicity cyclodextrins (CDs) are one of the most widely used hosts in the fi eld of inclusion chemistry. Usually composed of six to eight D -glucose units, CDs are capable of forming inclusion complexes with various guest moieties and polymeric chains. This capability is attributed to their ether-like oxygen and their hydrocarbon frame creating a hydrophobic cavity wherein appropriately sized molecules and macromolecules can be immobilized via tight, yet reversible associations. Using CD-based inclusion chemistry as a platform, a diverse range of polymeric networks with applications in the life sciences, biotechnology, and materials science can be achieved. This review highlights the versatility of CDbased inclusion chemistry, and how specifi city and control can be imparted when designing higher-order structures, such as those found in biological systems. A particularly interesting group of polymeric structures that is achievable via CD-based inclusion chemistry is that of CD-based The application of cyclodextrin (CD)-based host-guest interactions towards the fabrication of functional supramolecular assemblies and hydrogels is of particular interest in the fi eld of biomedicine. However, as of late they have found new applications as advanced functional materials (e.g., actuators and self-healing materials), which have renewed interest across a wide range of fi elds. Advanced supramolecular materials synthesized using this noncovalent interaction, exhibit specifi city and reversibility, which can be used to impart reversible cross-linking, specifi c binding sites, and functionality. In this review, various functional CD-based supramolecular assemblies and hydrogels will be outlined with the focus on recent advances. In addition, an outlook will be provided on the direction of this rapidly developing fi eld.

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Section: Cyclodextrin‐based Hydrogel Networkmentioning

confidence: 99%

Cyclodextrin‐Based Supramolecular Assemblies and Hydrogels: Recent Advances and Future Perspectives

Tan

Ladewig

et al. 2014

Macromol. Rapid Commun.

146

115

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“…The moisture adsorption properties of modified cyclodextrins affect the physicochemical properties and stability of the formulated drug, especially those where side chains occur. Introduction of polymer chains (e.g., dendrimer poly(ethylenimine) or poly-N -isopropylacrylamide) to cyclodextrin has been widely applied to drug complexations [8][9][10]. Derivatives of cyclodextrin with specific functional groups have also been synthesized and found applications in drug targeting [11,12].…”

Section: Introductionmentioning

confidence: 99%

Cationic-modified cyclodextrin nanosphere/anionic polymer as flocculation/sorption systems

Xiao

Cezar

2005

Journal of Colloid and Interface Science

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“…[41][42][43][44] First, 10 g of b-CD was dissolved in 15 mL of 15 wt% NaOH by stirring overnight at room temperature. Then the mixture was heated to 35 C and 7 mL of EPI was added in a 1 : 10 b-CD : EPI molar ratio.…”

Section: Preparation Of B-cdpmentioning

confidence: 99%

Synthesis and investigation of a self-assembled hydrogel based on hydroxyethyl cellulose and itsin vitroibuprofen drug release characteristics

Sun

Wang

2017

RSC Adv.

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Self-assembled cellulose-based hydrogels are a new type of supramolecular architecture with potential in biomedical applications. By our preparation, hydrophobic lauryl side-chains were grafted onto hydroxyethyl cellulose (HEC-C 12 ) and ibuprofen molecules were encapsulated and solubilized by poly In addition, the Korsmeyer-Peppas kinetic model gave a better correlation for the release of IBU, and the release procedure was a non-Fickian diffusion process.

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Water soluble cyclodextrin polymers: Their interaction with drugs

Cited by 60 publications

References 6 publications

Cyclodextrin‐Based Supramolecular Assemblies and Hydrogels: Recent Advances and Future Perspectives

Cyclodextrin‐Based Supramolecular Assemblies and Hydrogels: Recent Advances and Future Perspectives

Cationic-modified cyclodextrin nanosphere/anionic polymer as flocculation/sorption systems

Synthesis and investigation of a self-assembled hydrogel based on hydroxyethyl cellulose and itsin vitroibuprofen drug release characteristics

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