Water-soluble nonstoichiometric polyelectrolyte complexes of chitosan with a polystyrenesulfonate anion

Volkova, I. F.; Gorshkova, M. Yu.; Izumrudov, Vladimir A.

doi:10.1134/s0965545x0809006x

Cited by 10 publications

(10 citation statements)

References 20 publications

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“…[28] The turbidimetric titration curve of PSS 360 with Cts (Figure 7) typifies the phase behavior of the Cts/PSS system in strongly acidic media. At the initial stage, the titration does not result in phase separation, indicating the formation of soluble NPECs which proceeds up to a certain critical value Z cr ¼ [Cts]/[PSS 360 ] ¼ 0.30 (denoted by the arrow).…”

Section: Soluble Npecs As Products Of Complete Interpolyelectrolyte Rmentioning

confidence: 92%

“…[28] In brief, 4 mL of PSS solution, were neutralized with a 5 Â 10 À2 mol Á L À1 solution of tetramethylammonium hydroxide yielding NPECs soluble in neutral media. The concentration of PSS repeat units in the mixtures was 4.7 Â 10 À4 mol Á L À1 .…”

Section: Methodsmentioning

confidence: 99%

“…Recently, [28] we reported the preparation of negatively charged soluble NPECs, which was performed by titration of PSS solution with Cts solution in strongly acidic media, i.e., in the special case that Cts is protonated almost completely and the formation of hydrogen bonds is reduced to a minimum. Attempts to use the same approach in neutral media have not met with success.…”

Section: Soluble Npecs As Products Of Incomplete Interpolyelectrolytementioning

confidence: 99%

“…[28] However, for preparing NPECs, strongly acidic media are required. This restriction impairs the employment of the developed procedure, specifically the complexation of Cts with biopolymers.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Chitosan‐based Polyelectrolyte Complexes Soluble in Enzyme‐friendly pH Range

Izumrudov

Volkova

Gorshkova

2010

Macro Chemistry & Physics

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By studying chitosan interactions with poly(styrene sulfonate) anions, a procedure that yields chitosan‐based non‐stoichiometric polyelectrolyte complexes soluble in neutral media has been developed. The elaborated strategy of the complex formation depended on the peculiar order of mixing the polyelectrolyte solutions, which served as a remedy for kinetic hindrances. The kinetic restrictions inevitably occurred on direct mixing of the components in slightly acidic and neutral media, due to the significant contribution of hydrogen bonds in stabilization of the intermediate insoluble products. The approach developed opens up a new avenue of attack on the problem of preparing water soluble biocompatible and biodegradable chitosan complexes that are suitable for use at physiological pH and ionic strength.magnified image

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Section: Soluble Npecs As Products Of Complete Interpolyelectrolyte Rmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Soluble Npecs As Products Of Incomplete Interpolyelectrolytementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chitosan‐based Polyelectrolyte Complexes Soluble in Enzyme‐friendly pH Range

Izumrudov

Volkova

Gorshkova

2010

Macro Chemistry & Physics

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“…In [33][34][35][36][37][38][39], both approaches were further devel oped and gave encouraging results. Thus, in [33], sol uble NPECs were prepared via mixing of chitosan and PSS anion solutions in strongly acidic media.…”

Section: Imparting To Chitosan the Ability To Dissolve Under Physiolomentioning

confidence: 99%

Soluble polyelectrolyte complexes of biopolymers

Izumrudov

2012

Polym. Sci. Ser. A

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This review analyzes the papers reflecting the state of the art and achievements in the field of experimental investigations of solutions of polyelectrolyte complexes containing biopolymers, specifically oligomeric enzymes, cationic polysaccharide chitosan, or DNA. The analysis shows that the use of soluble complexes is promising for solving urgent practical problems. The development of methods for suppressing thermal aggregation of globular proteins without any substantial loss in functional activity, for imparting chi tosan the ability to dissolve under physiological conditions and to form polyelectrolyte complexes, and for creating dual action dendrimer carriers that can simultaneously deliver genetic material and drugs to cells are among the most significant directions.

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