Water-soluble octahedral molybdenum cluster compounds Na2[Mo6I8(N3)6] and Na2[Mo6I8(NCS)6]: Syntheses, luminescence, and in vitro studies

Kirakci, Kaplan; Kubát, Pavel; Kučeraková, Monika; Šícha, Václav; Gbelcová, Helena; Lovecká, Petra; Grznarova, Petra; Ruml, Tomáš; Lang, Kamil

doi:10.1016/j.ica.2015.10.043

Cited by 68 publications

(79 citation statements)

References 33 publications

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“…of NaN 3 or NaNCS was heated at 90 °C for 3 days in 2‐methoxyethanol, yielding Na 2 [Mo 6 I 8 (N 3 ) 6 ] and Na 2 [Mo 6 I 8 (NCS) 6 ]. X‐ray structures were determined for the solvates Na 2 [Mo 6 I 8 (N 3 ) 6 ] · 6(CH 3 ) 2 CO and Na 2 [Mo 6 I 8 (NCS) 6 ] · 6THF · 3H 2 O, grown from the appropriate solvents . Both sodium salts are well soluble in water.…”

Section: Octahedral Clusters: Chemistrymentioning

confidence: 99%

“…The IC 50 value (which shows the concentration necessary to achieve 50 % inhibition) was found to be 200 µ m . It is worth noting that both cluster anions hydrolyze with the release of one mole of N 3 – or NCS – per cluster, but resulting [{Mo 6 I 8 }(N 3 ) 5 (OH)] 2– and [{Mo 6 I 8 }(NCS) 5 (OH)] 2– remain in solution . A recent work studied cytotoxicity of cationic [Mo 6 I 8 L 6 ] 4+ complexes with zwitterionic carboxylates, 4‐(carboxybutyl)triphenylphophonium, Ph 3 P‐(CH 2 ) 4 ‐COO, and 4‐(carboxy)‐1‐methylpyridinium.…”

Section: Octahedral Clusters: Chemistrymentioning

confidence: 99%

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Molybdenum Iodides – from Obscurity to Bright Luminescence

Mikhaylov

Sokolov

2019

Eur J Inorg Chem

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This review is dedicated to the chemistry of Mo iodides. These compounds have a humble origin, and for a long time their chemistry has been almost completely neglected. Although important work on mononuclear and dinuclear Mo iodide complexes was done in 1980-1990s, the situation has dramatically changed within the last decade. The finding that the IntroductionThe iodides of transition metals attract much less attention than their chloride and bromide analogues, even though a book dealing exclusively with metal iodides was published half a century ago. [1] This is partly explainable by general lack of current or proposed practical use for this class of compounds. A notable exception offer the volatile iodides of Ti, Zr, and Hf, and of a few other metals, that can be used in the iodide process of van Arkel and de Boer. [2] Among the group 6 metals, this process can be applied for preparation of high purity chromium, which [a] Nikolaev His research interests focus on the coordination chemistry of 4d and 5d transition metals. Maxim Mikhaylov was born in Novosibirsk, (Russia). In 2009-2013 he completed his Ph. D. at the Laboratory of cluster and supramolecular compounds in the Nikolaev Institute of Inorganic Chemistry (NIIC) under suporevision of Prof. Dr. M. N. Sokolov. Now he is a researcher working in the Laboratory of synthesis of cooridnation compounds at NIIC. His research interests include synthesis of novel clusters and cluster complexes for the development of new materials.

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Section: Octahedral Clusters: Chemistrymentioning

confidence: 99%

Section: Octahedral Clusters: Chemistrymentioning

confidence: 99%

Molybdenum Iodides – from Obscurity to Bright Luminescence

Mikhaylov

Sokolov

2019

Eur J Inorg Chem

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“…14 Thirdly, such complexes are characterised by impressive photoluminescence quantum yields (PLQYs) for inorganic compounds. [24][25][26] All together these properties make hexamolybdenum cluster complexes very attractive for biomedical applications (e.g. [19][20][21][22] Fourthly, the cluster complexes are inherently highly electron dense and therefore can be used as contrast agents in transmission electron microscopy (TEM) and X-Ray imaging.…”

Section: Introductionmentioning

confidence: 99%

“…23 Finally, the low toxicity of the molybdenum octahedral cluster complexes and derived materials was evidenced by different research groups. 25,30 However, these ligands do not protect the molybdenum cluster from the hydrolysis. biolabeling and diagnostic bioimaging), therapeutic (PDT agents) and even combined diagnostic and therapeutic (theranostic) applications.…”

Section: Introductionmentioning

confidence: 99%

Cellular internalisation, bioimaging and dark and photodynamic cytotoxicity of silica nanoparticles doped by {Mo₆I₈}⁴⁺ metal clusters

et al. 2016

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Silica nanoparticles (SNPs) doped by hexanuclear molybdenum cluster complexes [{Mo6X8}L6] n (X = Cl, Br, or I; L = various inorganic or organic ligands) have been recently suggested as materials with a high potential for biomedical applications due to both the outstanding photoluminescent properties and the ability to efficiently generate singlet oxygen upon photoirradiation. However, no studies were undertaken so far to prove this concept. Therefore, here we examined the potential of photoluminescent SNPs doped by {Mo6I8} 4+ for such applications as bioimaging and photodynamic therapy using human epidermoid larynx carcinoma (Hep-2) cell line as a model. Our results demonstrated both: (i) significant luminescence from cells with internalised molybdenum cluster-doped SNPs combined with the low cytotoxicity of particles in the darkness and (ii) significant cytotoxicity of the particles upon photoirradiation. Thus, this research provides strong experimental evidence for high potential of molybdenum-cluster-doped materials in such biomedical applications as optical bioimaging, biolabeling and photodynamic therapy.

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“…Biomarkers, specifically cancer biomarkers, are an indication of cancer and by detecting them, the existence of that specific cancer can be verified [53]. The potential biomedical application of luminescent clusters requires the evaluation of cellular uptake, subcellular localization, cytotoxicity, and biocompatibility in vitro [13,54]. This report describes the use of clusters as a specific biomarker agent against tumor cells.…”

Section: Resultsmentioning

confidence: 99%

The [Mo6Cl14]2− Cluster is Biologically Secure and Has Anti-Rotavirus Activity In Vitro

et al. 2017

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The molybdenum cluster [Mo6Cl14]2− is a fluorescent component with potential for use in cell labelling and pharmacology. Biological safety and antiviral properties of the cluster are as yet unknown. Here, we show the effect of acute exposition of human cells and red blood cells to the molybdenum cluster and its interaction with proteins and antiviral activity in vitro. We measured cell viability of HepG2 and EA.hy926 cell lines exposed to increasing concentrations of the cluster (0.1 to 250 µM), by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay. Hemolysis and morphological alterations of red blood cells, obtained from healthy donors, exposed to the cluster (10 to 200 µM) at 37 °C were analyzed. Furthermore, quenching of tryptophan residues of albumin was performed. Finally, plaque formation by rotavirus SA11 in MA104 cells treated with the cluster (100 to 300 µM) were analyzed. We found that all doses of the cluster showed similar cell viability, hemolysis, and morphology values, compared to control. Quenching of tryptophan residues of albumin suggests a protein-cluster complex formation. Finally, the cluster showed antiviral activity at 300 µM. These results indicate that the cluster [Mo6Cl14]2− could be intravenously administered in animals at therapeutic doses for further in vivo studies and might be studied as an antiviral agent.

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Water-soluble octahedral molybdenum cluster compounds Na2[Mo6I8(N3)6] and Na2[Mo6I8(NCS)6]: Syntheses, luminescence, and in vitro studies

Cited by 68 publications

References 33 publications

Molybdenum Iodides – from Obscurity to Bright Luminescence

Molybdenum Iodides – from Obscurity to Bright Luminescence

Cellular internalisation, bioimaging and dark and photodynamic cytotoxicity of silica nanoparticles doped by {Mo₆I₈}⁴⁺ metal clusters

The [Mo6Cl14]2− Cluster is Biologically Secure and Has Anti-Rotavirus Activity In Vitro

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Water-soluble octahedral molybdenum cluster compounds Na2[Mo6I8(N3)6] and Na2[Mo6I8(NCS)6]: Syntheses, luminescence, and in vitro studies

Cited by 68 publications

References 33 publications

Molybdenum Iodides – from Obscurity to Bright Luminescence

Molybdenum Iodides – from Obscurity to Bright Luminescence

Cellular internalisation, bioimaging and dark and photodynamic cytotoxicity of silica nanoparticles doped by {Mo6I8}4+ metal clusters

The [Mo6Cl14]2− Cluster is Biologically Secure and Has Anti-Rotavirus Activity In Vitro

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Cellular internalisation, bioimaging and dark and photodynamic cytotoxicity of silica nanoparticles doped by {Mo₆I₈}⁴⁺ metal clusters