Water-Soluble “Poly(propylene oxide)” by Random Copolymerization of Propylene Oxide with a Protected Glycidol Monomer

Schömer, Martina; Frey, Holger

doi:10.1021/ma300249c

Cited by 46 publications

(54 citation statements)

References 28 publications

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“…[G4.0] Polyglycerol dendrimer dPG 100 : 1 H NMR (400 MHz, CD 3 OD, d) ¼ 3.82-3.68 (m, -OCH 2 CH-), 3.65-3.49 (m, -OCH 2 -), 3.43 (m, -OCH 2 C-); 13 24 ) with Lower DB hPG with DB of 42 and 24% were synthesized via an anionic ringopening copolymerization of glycidol and EEGE in a well-stirred batch reactor (V ¼ 1 L). For DB ¼ 42%, TMP (5.56 mmol, 746 mg) was melted at 65 8C under high vacuum and subsequently deprotonated by adding KOtBu (1.67 mmol, 1.67 mL of 1 M solution in dry THF).…”

Section: Polyglycerol Dendrimer Generation 4 (Dpg 100 )mentioning

confidence: 99%

“…In the past decade, studies on polyglycerol hybrids with lower DB were based on copolymerization with ethylene oxide, propylene oxide, or macromonomers like PEG, and functionalized PG derivatives . The investigated architectures were not fully glycerol based and there were fewer functional groups both on the surface and within the scaffold.…”

Section: Introductionmentioning

confidence: 99%

“…M w;GPC ¼ 5.8 kDa, PDI ¼ 1.45; M n;NMR ¼ 4.7 kDa; yield: 87%; 1 H NMR (400 MHz, CD 3 OD, d): 4.00-3.40 (m, hPG backbone), 1.37 (q, methylene group -CH 2 CH 3 , TMP initiator), 0.88 (t, ethyl group -CH 2 CH 3 , TMP initiator) 13. C NMR (175 MHz, D 2 O, d): 80.0-79.0 (hPG backbone, linear 1-3 units), 78.5-77.5 (hPG backbone, dendritic units), 72.5-71.5 (hPG backbone, linear 1-4 units), 71.5-70.0 (hPG backbone, linear/dendritic units) 70.0-68.5 (hPG backbone, linear 1-3/1-4 units), 63.0-62.0 (hPG backbone, terminal units), 61.5-60.0 (hPG backbone, linear 1-3 units), 43.1, 22.4, 7.1 (TMP initiator); DB ¼ 42%.…”

mentioning

confidence: 99%

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The Effect of Polyglycerol Sulfate Branching On Inflammatory Processes

Paulus

Schulze

Steinhilber

et al. 2014

Macromolecular Bioscience

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In this study, the extent to which the scaffold architecture of polyglycerol sulfates affects inflammatory processes and hemocompatibility is investigated. Competitive L-selectin binding assays, cellular uptake studies, and blood compatibility readouts are done to evaluate distinct biological properties. Fully glycerol based hyperbranched polyglycerol architectures are obtained by either homopolymerization of glycidol (60% branching) or a new copolymerization strategy of glycidol with ethoxyethyl glycidyl ether. Two polyglycerols with 24 and 42% degree of branching (DB) are synthesized by using different monomer feed ratios. A perfectly branched polyglycerol dendrimer is synthesized according to an iterative two-step protocol based on allylation of the alcohol and subsequent catalytic dihydroxylation. All the polyglycerol sulfates are synthesized with a comparable molecular weight and degree of sulfation. The DB make the different polymer conjugates perform different ways. The optimal DB is 60% in all biological assays.

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Section: Polyglycerol Dendrimer Generation 4 (Dpg 100 )mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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The Effect of Polyglycerol Sulfate Branching On Inflammatory Processes

Paulus

Schulze

Steinhilber

et al. 2014

Macromolecular Bioscience

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“…Note that this transition is reproducible for repeated heating cycles (Figure S1, Supporting Information), which confirms a rapid and reversible bonding of the supramolecular linkages in the PG matrix. Correspondingly, differential scanning calorimetry (DSC) reveals a T g at 17.8 °C (second heating, Figure b top), which is significantly above pure PG, typically ranging from ≈−30 to −10 °C . This also confirms arrested chain mobility by implementation of the supramolecular linkages.…”

Section: Resultsmentioning

confidence: 63%

Light‐Fueled, Spatiotemporal Modulation of Mechanical Properties and Rapid Self‐Healing of Graphene‐Doped Supramolecular Elastomers

Noack

Merindol

Zhu

et al. 2017

Adv Funct Materials

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Gaining spatially resolved control over the mechanical properties of materials in a remote, programmable, and fast-responding way is a great challenge toward the design of adaptive structural and functional materials. Reversible, temperature-sensitive systems, such as polymers equipped with supramolecular units, are a good model system to gain detailed information and target large-scale property changes by exploiting reversible crosslinking scenarios. Here, it is demonstrated that coassembled elastomers based on polyglycidols functionalized with complementary cyanuric acid and diaminotriazine hydrogen bonding couples can be remotely modulated in their mechanical properties by spatially confined laser irradiation after hybridization with small amounts of thermally reduced graphene oxide (TRGO). The TRGO provides an excellent photothermal effect, leads to light-adaptive steady-state temperatures, and allows local breakage/de-crosslinking of the hydrogen bonds. This enables fast self-healing and spatiotemporal modulation of mechanical properties, as demonstrated by digital image correlation. This study opens pathways toward light-fueled and light-adaptive graphene-based nanocomposites employing molecularly controlled thermal switches.

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“…This can be achieved via copolymerization of PDMA with PPO, which adds tertiary amine group to the PPO chain in its backbone structure. [13][14][15] Interest in catechol compounds has increased recently because of their surface adhesion properties and compatibility with metals. Under mild alkaline conditions, catechol compounds can modify surfaces by forming a network through cross-linking as well as oxidized to form o-quinone, which can subsequently react with various functional groups via Michael addition or Schiff's base reactions.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and antibacterial activity of surface‐coated catechol‐conjugated polymer with silver nanoparticles on versatile substrate

Kim

Lee

et al. 2016

Surface & Interface Analysis

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In the present study, 2-chloro-3′,4′-dihydroxyacetophenone (CCDP), a catechol derivative, was quaternized with poly(propylene oxide)-g-poly(dimethylaminoethyl methacrylate) (PPO-g-PDMA, PgP) to prepare surface coatings for various substrates. The surfaces of noble metals, oxides, and synthetic polymers were coated by immersion in an aqueous solution of CCDP quaternized with PgP (C-PgP). The catechol functional groups that remained on the surface were used for deposition of Ag nanoparticles (AgNPs) on the coated surface, to provide a water-resistant antibacterial polymer with long-term antimicrobial activity. X-ray photoelectron spectroscopy confirmed deposition of C-PgP and AgNPs on the surface coated with the antibacterial polymer. Surfaceimmobilized C-PgP/AgNPs showed outstanding antibacterial activities against Staphylococcus aureus, a Gram-positive bacterium, and Escherichia coli, a Gram-negative bacterium. C-PgP/AgNPs can be applied to a variety of substrates and can therefore be used as antibacterial materials in various fields.

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Water-Soluble “Poly(propylene oxide)” by Random Copolymerization of Propylene Oxide with a Protected Glycidol Monomer

Cited by 46 publications

References 28 publications

The Effect of Polyglycerol Sulfate Branching On Inflammatory Processes

The Effect of Polyglycerol Sulfate Branching On Inflammatory Processes

Light‐Fueled, Spatiotemporal Modulation of Mechanical Properties and Rapid Self‐Healing of Graphene‐Doped Supramolecular Elastomers

Synthesis and antibacterial activity of surface‐coated catechol‐conjugated polymer with silver nanoparticles on versatile substrate

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