Water Sorption Induced Transformations in Crystalline Solid Surfaces: Characterization by Atomic Force Microscopy

Chen, Dabing; Haugstad, Greg; Li, Zheng Jane; Suryanarayanan, Raj

doi:10.1002/jps.22258

Cited by 16 publications

(9 citation statements)

References 66 publications

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“…It is worth noting that TGA and/or VSA have been widely used to investigate hygroscopic properties of pharmaceutical materials. For example, at room temperature anhydrous theophylline was observed to transform to hydrate at 62% RH, and its DRH was determined to be 99% (Chen et al, 2010).…”

Section: Thermogravimetric Analysismentioning

confidence: 99%

A review of experimental techniques for aerosol hygroscopicity studies

Tang¹,

Chan²,

Li³

et al. 2019

Preprint

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<p><strong>Abstract.</strong> Hygroscopicity is one of the most important physicochemical properties of aerosol particles, and also plays indispensable roles in many other scientific and technical fields. A myriad of experimental techniques, which differ in principles, configurations and cost, are available for investigating aerosol hygroscopicity under subsaturated conditions (i.e., relative humidity below 100&#8201;%). A comprehensive review of these techniques is provided in this paper, in which experimental techniques are broadly classified into four categories, according to the way samples under investigation are prepared. For each technique, we describe its operation principle and typical configuration, use representative examples reported in previous work to illustrate how this technique can help better understand aerosol hygroscopicity, and discuss its advantages and disadvantages. In addition, future directions are outlined and discussed for further technical improvement and instrumental development.</p>

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Section: Thermogravimetric Analysismentioning

confidence: 99%

A review of experimental techniques for aerosol hygroscopicity studies

Tang¹,

Chan²,

Li³

et al. 2019

Preprint

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“…It can be assumed that also the skgm crystals and, in general, all needles obtained start to grow from small impurities (heterogeneous nucleation mechanism). With regard to the conventional method, it is to suggest that the nucleation of the needle crystals can take place at defects [11,14] on the surface of the crystal, but also on dust particles adhering to the monohydrate crystals.…”

Section: Needle Crystalsmentioning

confidence: 99%

Generation of Crystalline Hollow Needles: New Approach by Liquid‐Liquid Phase Transformation

2011

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The formation of hollow crystalline needles by means of a solvent-mediated phase transformation takes place during the dehydration of hydrate crystals in methanol into hollow needle-shaped anhydrate crystals. Here, a special way of achieving needle growth is presented. When a saturated aqueous solution of sodium-2-ketogulonate is dropped into methanol, a simultaneous nucleation of monohydrate crystals and anhydrate needles takes place in the alcohol. It was proven by scanning electron microscope images that these needles are hollow. By means of the variation of the production method, it is for the first time possible to observe the needle growth in a more detailed manner, and to show that the nucleation can take place at impurities and surface roughnesses. The method helped to discuss and to deepen the understanding of the growth mechanism of the hollow crystalline needles.

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“…At the room temperatures and relative air humidity, hygroscopic properties of substances have several phases (polymorphs), which are able to transfer into each other. Certainly, these facts strongly complicate the evaluation of product behavior in the moist atmosphere …”

Section: Thermodynamic Approach To the Scientific Reviews In The Fielmentioning

confidence: 99%

“…Certainly, these facts strongly complicate the evaluation of product behavior in the moist atmosphere. [41][42][43] However, if to speak about problems of crystalline-soluble solids hygroscopicity, the main issues arise, when researchers neglect the influence of soluble impurities on hygroscopic properties of a product. Some of them are considered below.…”

Section: Thermodynamic Approach To the Scientific Reviews In The Fielmentioning

confidence: 99%

Deliquescence: Hygroscopicity of Water-Soluble Crystalline Solids

Tereshchenko

2015

Journal of Pharmaceutical Sciences

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Water Sorption Induced Transformations in Crystalline Solid Surfaces: Characterization by Atomic Force Microscopy

Cited by 16 publications

References 66 publications

A review of experimental techniques for aerosol hygroscopicity studies

A review of experimental techniques for aerosol hygroscopicity studies

Generation of Crystalline Hollow Needles: New Approach by Liquid‐Liquid Phase Transformation

Deliquescence: Hygroscopicity of Water-Soluble Crystalline Solids

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