Water state characterization, swelling behavior, thermal and mechanical properties of chitosan based networks

Development of mucoadhesive thiolated chitosan nanoparticles for biomedical applications

“…This can be explained by the fact that the chain scission in the case of TCS is easier because of the presence of easily breakable side chains (due to thiolation -NH-CO-CH 2 -SH), where as in the case of TPP cross-linked TCS i.e. in TCS-NPs degradation is much difficult than TCS, this can be explained by the TPP cross-linking, this makes the thermal degradation difficult (Khalid, Agnely, Yagoubi, Grossiord, & Couarraze, 2002).…”

Characterization and Antitumor Activity of Chitosan/Poly (Vinyl Alcohol) Blend Doped with Gold and Silver Nanoparticles in Treatment of Prostatic Cancer Model

“…This protonation induces electrostatic repulsions between the polymer segments. Besides, the protonation of the amino-groups may lead to the dissociation of hydrogen bonds among the polymers and thus to a relaxation of the macromolecular chains [27]. When Cs/PVA blend is in neutral or alkaline media, the swelling is strongly reduced due to the deprotonation of the amino-groups.…”

Release profile and stability evaluation of optimized chitosan/alginate nanoparticles as EGFR antisense vector

“…9,10 It is well established that water exists in polymer networks of hydrogels in three different physical states, ie, free water that can freeze at the usual freezing point, intermediate water that freezes at a temperature lower than the usual freezing point, and bond water which cannot freeze at the usual freezing point. Biomedical or pharmaceutical activity depends on how the water molecules associate with the polymer.…”

“…Moreover, the swelling characteristics of hydrogels are dominated by the nature of the polymer and the state of water. 9 The ability of the nanoparticles to swell was investigated by evaluation of their size increase in medium buffer after freeze-drying, to ensure that the nanoparticles could be reswelled again in aqueous solution and release their drug content during swelling.…”