Water vole management - Could anticoagulant rodenticides stereochemistry mitigate the ecotoxicity issues associated to their use?

Seasonal diet-based resistance to anticoagulant rodenticides in the fossorial water vole (Arvicola amphibius)

“…Consistent with this distribution, enzymatic characterization revealed that the presence of this mutation does not lead to resistance to bromadiolone, a second-generation anticoagulant, nor to cis-bromadiolone. This latter can be assimilated by its short persistence to a first generation anticoagulant and may constitute an eco-compatible alternative to the current use of bromadiolone (Damin-Pernik et al 2017, Abi Khalil et al, 2021. The S149I mutation was found at a lower allelic frequency (0.5%) and systematically in the heterozygous state.…”

“…A metabolic resistance of genetic origin could be considered as the one described in black (Sugano et al, 2001 ;Ishizuka et al, 2007) or brown rats (Boitet et al, 2018). Nevertheless, since the persistence of bromadiolone is long-lasting in the fossorial water vole (Abi Khalil et al, 2021), a simple overexpression of metabolic enzymes capable of conferring metabolic resistance is doubtful. Other genetic mechanisms supported by other genes have been proposed in humans (Wadelius et al, 2007), but their involvement has not been proven.…”

Calcium-Alginate-Chitosan Nanoparticle as a Potential Solution for Pesticide Removal, a Computational Approach

“…Its application in open areas is not recommended due to its ecotoxicity. It has also been reported that difenacoum shows persistence in tissues, which could cause death in exposed species [ 73 ]; therefore, this compound has a high ecotoxicity.…”

Interest of the faecal and plasma matrix for monitoring the exposure of wildlife or domestic animals to anticoagulant rodenticides

“…Accidental exposures and poisonings to ARs have been widely documented worldwide in humans, pets, livestock, and wildlife, posing a public health concern due to this non-selectivity [2]. The involvement of the different ARs in the exposure of non-target wildlife has been reported to differ depending on the properties of the ARs and their generation, with longer tissue persistence and stronger anticoagulant potency for SGARs [3,4]. Concurrently, the consequences of exposure to ARs have been suggested to vary between species with species more sensitive and more frequently exposed to ARs [5], but also according to different individual factors such as sex, diet, physiological and nutritional status.…”