Waterborne polyurethanes: Spectroscopy and stability of emulsions

Zhang, Subiao; Lv, Hongtao; Zhang, Han; Wang, Bing; Xu, Yiting

doi:10.1002/app.23354

Cited by 29 publications

(30 citation statements)

References 24 publications

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“…NPs. 9,12 The present findings in rats and the previously published results for mice indicate that the investigated Se-proteins were up-regulated dependent on the supplemented dose of Se, but largely independent of its chemical form.…”

Section: Absorption and Distribution Of Sesupporting

confidence: 75%

“…12 The results showed less toxicity of the nanoform, and Se 0 NPs were as efficient as the two molecular Se forms in inducing the formation of Se-dependent enzymes. In a sub-chronic toxicity study with rats, the nano-Se source was inferior in toxicity to that of Se(IV) or Se-rich protein used as sources of Se.…”

Section: Introductionmentioning

confidence: 90%

“…The low dose at 0.05 mg Se per kg bw per day was chosen as toxicological effects were not expected, and the high dose at 0.5 mg Se per kg bw per day was chosen as a supra-nutritional dose where toxicological effects were likely to occur. 12,13 The intrinsic Se concentration in the rats' feed was (mean AE one s.d.) 250 AE 54 ng g À1 (N = 3), which influenced the Se content in the control animals.…”

Section: Absorption and Distribution Of Sementioning

confidence: 99%

“…However, when administering a supra-nutritional dose (1 mg kg À1 bw per day) the Se concentration was higher in the MeSeCys exposed animals. 12 NPs was calculated from the difference in Se concentration in the sample (no sulfite treatment) and that in the supernatant of the sulfite-treated sample. 12 The indirect nature of this analytical approach would benefit from a more direct method of analysis for the SeSO 3 2À reaction product.…”

Section: Introductionmentioning

confidence: 99%

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Absorption, distribution, metabolism and excretion of selenium following oral administration of elemental selenium nanoparticles or selenite in rats

et al. 2014

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A suspension of nanoparticles of BSA-stabilized red amorphous elemental selenium (Se) or an aqueous solution of sodium selenite was repeatedly administered by oral gavage for 28 days at 0.05 mg kg À1 bw per day (low dose) or at 0.5 mg kg À1 bw per day (high dose) as Se to female rats. Prior to administration, the size distribution of the Se nanoparticles was characterized by dynamic light scattering and transmission electron microscopy, which showed that the particles' mean diameter was 19 nm and ranged in size from 10 to 80 nm. Following administration of the high dose of Se nanoparticles or selenite the concentration of Se was determined by ICP-MS in the liver, kidney, urine, feces, stomach, lungs, and plasma at the mg g À1 level and in brain and muscle tissue at the sub-mg g À1 level. In order to test if any elemental Se was present in the liver, kidney or feces, an in situ derivatization selective to elemental Se was performed by treatment with sulfite, which resulted in formation of the selenosulfate anion. This Se species was selectively and quantitatively determined by anion exchange HPLC and ICP-MS detection. The results showed that elemental Se was present in the livers, kidneys and feces of animals exposed to low and high doses of elemental Se nanoparticles or to selenite, and was also detected in the same samples from control animals. The fraction of Se present as elemental Se in livers and kidneys from the high dose animals was significantly larger than the similar fraction in samples from the low dose animals or from the controls.This suggested that the natural metabolic pathways of Se were exhausted when given the high dose of elemental Se or selenite resulting in a non-metabolized pool of elemental Se. Both dosage forms of Se were bioavailable as demonstrated by the blood biomarker selenoprotein P, which was equally up-regulated in the high-dose animals for both dosage forms of Se. Finally, the excretion of Se in urine and its occurrence as Se-methylseleno-N-acetyl-galactosamine and the trimethylselenonium-ion demonstrated that both dosage forms were metabolized and excreted. The results of the study showed that both forms of Se were equally absorbed, distributed, metabolized and excreted, but the detailed mechanism of the fate of the administered elemental Se or selenite in the gastro-intestinal tract of rats remains unclear.

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Section: Absorption and Distribution Of Sesupporting

confidence: 75%

Section: Introductionmentioning

confidence: 90%

Section: Absorption and Distribution Of Sementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Absorption, distribution, metabolism and excretion of selenium following oral administration of elemental selenium nanoparticles or selenite in rats

et al. 2014

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“…in PU was composed of free N-H and the hydrogen bonded N-H. 29 The prepared PU1 NPs had an absorption peak at 3,373 cm -1 , consistent with the literature data. 29 After SPIO NPs were encapsulated in PU1 NPs by sonication, the N-H stretching absorption peak of SPIO-PU1 NPs shifted from 3,373 to 3,347 cm -1 , representing more bonded N-H through the interaction of SPIO with the N-H bond of PU NPs.…”

Section: Discussionsupporting

confidence: 87%

A facile method to prepare superparamagnetic iron oxide and hydrophobic drug-encapsulated biodegradable polyurethane nanoparticles

Cheng

Hsu

2017

IJN

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Superparamagnetic iron oxide nanoparticles (SPIO NPs) have a wide range of biomedical applications such as in magnetic resonance imaging, targeting, and hyperthermia therapy. Aggregation of SPIO NPs can occur because of the hydrophobic surface and high surface energy of SPIO NPs. Here, we developed a facile method to encapsulate SPIO NPs in amphiphilic biodegradable polymer. Anionic biodegradable polyurethane nanoparticles (PU NPs) with ~35 nm size and different chemistry were prepared by waterborne processes. SPIO NPs were synthesized by chemical co-precipitation. SPIO NPs were then added to the aqueous dispersion of PU NPs, followed by application of high-frequency (~20 kHz) ultrasonic vibration for 3 min. This method rendered SPIO-PU hybrid NPs (size ~110 nm) suspended in water. SPIO-PU hybrid NPs contained ~50–60 wt% SPIO and retained the superparamagnetic property (evaluated by a magnetometer) as well as high contrast in magnetic resonance imaging. SPIO-PU NPs also showed the ability to provide cell hyperthermic treatment. Using the same ultrasonic method, hydrophobic drug (Vitamin K3 [VK3]) or (9-(methylaminomethyl) anthracene [MAMA]) could also be encapsulated in PU NPs. The VK3-PU or MAMA-PU hybrid NPs had ~35 nm size and different release profiles for PUs with different chemistry. The encapsulation efficiency for VK3 and MAMA was high (~95%) without burst release. The encapsulation mechanism may be attributed to the low glass transition temperature (Tg) and good mechanical compliance of PU NPs. The new encapsulation method involving waterborne biodegradable PU NPs is simple, rapid, and effective to produce multimodular NP carriers.

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Preparation and characterization of waterborne polyurethane based on diphenylmethane diisocyanate‐50

Xiao

Zhao

et al. 2016

Adv Polym Technol

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A new waterborne polyurethane was prepared using diphenylmethane diisocyanate-50. Properties of this waterborne polyurethane and the conventional isophorone diisocyanante-based waterborne polyurethane were tested. It was found that diphenylmethane diisocyanate-50-based waterborne polyurethane showed better properties compared to isophorone diisocyanantebased waterborne polyurethane. The films of diphenylmethane diisocyanate-50-based waterborne polyurethane had higher tensile strength than of isophorone diisocyanante-based waterborne polyurethane; their water resistance and thermal stability were also improved. And they have higher surface hydrophobicity compared with those of isophorone diisocyanante-based waterborne polyurethane. It's believed that diphenylmethane diisocyanate-50-based waterborne polyurethane has excellent application performance in many industrial fields.

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Waterborne polyurethanes: Spectroscopy and stability of emulsions

Cited by 29 publications

References 24 publications

Absorption, distribution, metabolism and excretion of selenium following oral administration of elemental selenium nanoparticles or selenite in rats

Absorption, distribution, metabolism and excretion of selenium following oral administration of elemental selenium nanoparticles or selenite in rats

A facile method to prepare superparamagnetic iron oxide and hydrophobic drug-encapsulated biodegradable polyurethane nanoparticles

Preparation and characterization of waterborne polyurethane based on diphenylmethane diisocyanate‐50

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