Watery Rose Apple: A Comprehensive Review of Its Traditional Uses, Nutritional Value, Phytochemistry, and Therapeutic Merits against Inflammation-Related Disorders

Yassir, Mouna; Bakrim, Widad Ben; Mahmoud, Mona F.; Drissi, Badreddine; Kouisni, Lamfeddal; Sobeh, Mansour

doi:10.1155/2022/7502185

Cited by 7 publications

(6 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings agree with those reported from the Egyptian flora (Sobeh et al, 2018a). Also, other Syzygium species showed similar chemical patterns, among them Syzygium cumini, Syzygium samarangense, Syzygium aqueum; they are polyphenolsrich medicinal plants containing myricetin and gallic acid (Sobeh et al, 2018b;Chagas et al, 2018;Sobeh et al, 2018c;Gaspar et al, 2020;Yassir et al, 2022).…”

Section: Phytochemical Composition Of the Aqueous Extract Of S Jambos...supporting

confidence: 91%

Chemical profiling and dermatological and anti-aging properties of Syzygium jambos L. (Alston): evidence from molecular docking, molecular dynamics, and in vitro experiments

Mahdi,

Imbimbo,

Ortaakarsu

et al. 2024

Front. Mol. Biosci.

Self Cite

View full text Add to dashboard Cite

The phytoconstituents of the aqueous extract from Syzygium jambos L. (Alston) leaves were defined using HPLC-PDA-MS/MS and the antioxidant, anti-aging, antibacterial, and anti-biofilm activities of the extract were in silico and in vitro investigated. The antioxidant activities were performed using in vitro DPPH and FRAP assays as well as H2-DCFDA assay in HaCaT cells in which oxidative stress was induced by UVA radiation. Anti-aging activity was tested in vitro, using aging-related enzymes. The antibacterial, anti-biofilm and inhibitory effects on bacterial mobilities (swarming and swimming) were assessed against Pseudomonas aeruginosa. Results showed that S. jambos aqueous extract contained 28 phytochemicals belonging to different metabolite classes, mainly phenolic acids, gallic acid derivatives, flavonoids, and ellagitannins. Mineral content analysis showed that S. jambos leaves contained moderate amounts of nitrogen, potassium, manganese, magnesium, and zinc, relatively low amounts of phosphorus and copper, and high concentration of calcium and iron. The extract displayed strong antioxidant activities in vitro and inhibited UVA-induced oxidative stress in HaCaT cells. Docking the major compounds identified in the extract into the four main protein targets involved in skin aging revealed an appreciable inhibitory potential of these compounds against tyrosinase, elastase, hyaluronidase, and collagenase enzymes. Moreover, molecular dynamic simulations were adopted to confirm the binding affinity of some selected compounds towards the target enzymes. The extract exhibited pronounced in vitro anti-aging effects, compared to kojic acid and quercetin (the reference compounds). It also inhibited the growth of P. aeruginosa, counteracted its ability to form biofilm, and impeded its swarming and swimming mobilities. Altogether, these findings strongly propose S. jambos leaves as a promising source of bioactive metabolites for the development of natural cosmeceutical and dermatological agents.

show abstract

Section: Phytochemical Composition Of the Aqueous Extract Of S Jambos...supporting

confidence: 91%

Chemical profiling and dermatological and anti-aging properties of Syzygium jambos L. (Alston): evidence from molecular docking, molecular dynamics, and in vitro experiments

Mahdi,

Imbimbo,

Ortaakarsu

et al. 2024

Front. Mol. Biosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recently, there has been a keen interest in identifying new plant-based antioxidants to protect the human body from free radical-related disorders such as diabetes, cancer, cardiovascular and neurodegenerative diseases, atherosclerosis, arthritis, asthma, anemia, inflammation, and so forth ( Pham-Huy et al, 2008 ; Yassir et al, 2022 ). Many research studies showed that various plant species contained significant amounts of polyphenolic compounds and flavonoids, which could also be applied as promising antioxidant agents in dietary supplements and as food additives to postpone or prevent rancidity.…”

Section: Biological Activities Of T Articulatamentioning

confidence: 99%

Tetraclinis articulata (vahl) masters: An insight into its ethnobotany, phytochemistry, toxicity, biocide and therapeutic merits

2022

Self Cite

View full text Add to dashboard Cite

Tetraclinis articulata (Vahl) Masters, commonly known as Sandarac tree and Araâr, is the only species representing the genus Tetraclinis Masters. The plant has been extensively used for medicinal, artistic, and ritual purposes since its first recorded use in 1800 B.C. Recently, a full range of ethnobotanical investigations has been undertaken to document the plant’s empirical knowledge. They reported the use of different parts, such as leaves, stems, cones, bark, and roots, as part of folk healing practices to manage diabetes mellitus, hypertension, fever, stomach disorders, and diarrhea, among others. The phytochemical studies have identified at least 130 compounds from leaves, cones, resin, bark, and woods. These chemical constituents are categorized into phenolic acids, flavonoids and their derivatives, volatile compounds, phytosterols, and fatty acids, among others. Furthermore, they have strongly been correlated with the promising antimicrobial, antioxidant, neuroprotective, antiurolithiatic, anti-inflammatory, antidiabetic, and cytotoxic properties of the plant. Toxicological studies argued that the plant is quite safe and devoid of eventual toxicity; however, in-depth investigations are required to validate the safety of the plant. The remarkable antimicrobial and antioxidant potencies of various extracts from the plant against a wide range of foodborne pathogens support their possible use to increase the shelf life of foodstuffs in the food industry. Likewise, various plant-based extracts have been proven to exert substantial biocidal properties, making them potential alternatives to synthetic pesticides in agriculture. The present review provides an up-to-date comprehensive insight about the ethnobotanical uses of T. articulata, along with its phytochemistry and biological activities to furnish directions for further studies. We also discussed the biocidal potency of the plant and highlighted its usage to extend the shelf life of perishable foods.

show abstract

“…Several disorders and diseases are linked to the inflammatory responses including diabetes mellitus, rheumatoid arthritis, neurodegenerative diseases, and cancer ( 42 ). Many anti-inflammatory agents were isolated from plants such as curcumin, quercetin, capsaicin, resveratrol, and epigallocatechin-3-gallate ( 43 ).…”

Section: Biological and Pharmacological Activitiesmentioning

confidence: 99%

Cubeb (Piper cubeba L.f.): A comprehensive review of its botany, phytochemistry, traditional uses, and pharmacological properties

et al. 2022

Self Cite

View full text Add to dashboard Cite

Piper cubeba L.f. (Piperaceae), known as cubeb, is a popular traditional herbal medicine used for the treatment of many diseases, especially digestive and respiratory disorders. The plant is rich in essential oil, found mainly in fruits, and this makes it economically important. Many traditional utilizations have been also validated from the plant and its isolated compounds owing to their antioxidant, antibacterial, anti-inflammatory and anticancer effects. These biological activities are attributed to the phytochemicals (phenolic compounds, lignans and alkaloids) and the essential oil of the plant. The present work aims to provide an up-to-date review on the traditional uses, phytochemistry and pharmacology of the plant and discusses the future perspectives to promote its valorization for nutritional- and health-promoting effects.

show abstract

Watery Rose Apple: A Comprehensive Review of Its Traditional Uses, Nutritional Value, Phytochemistry, and Therapeutic Merits against Inflammation-Related Disorders

Cited by 7 publications

References 54 publications

Chemical profiling and dermatological and anti-aging properties of Syzygium jambos L. (Alston): evidence from molecular docking, molecular dynamics, and in vitro experiments

Chemical profiling and dermatological and anti-aging properties of Syzygium jambos L. (Alston): evidence from molecular docking, molecular dynamics, and in vitro experiments

Tetraclinis articulata (vahl) masters: An insight into its ethnobotany, phytochemistry, toxicity, biocide and therapeutic merits

Cubeb (Piper cubeba L.f.): A comprehensive review of its botany, phytochemistry, traditional uses, and pharmacological properties

Contact Info

Product

Resources

About