WAY 100135, a selective 5-HT1A receptor antagonist attenuates 9-OH-DPAT-induced feeding in rats

Hartley, J.E.; Fletcher, A.

doi:10.1016/0195-6663(92)90076-i

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-Hta Receptor Antagonists1

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1993

1998

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“…Finally, it might be predicted from the hyperphagic effects of 5-HTIA receptor agonists that 5-HTIA receptor antagonists could possess anorectic effects. However, to date, experiments with WAY 100135 and WAY 100635 have failed to identify any anorectic effects of selective 5-HTIA receptor blockade, suggesting that the 5-HTIA receptor population involved in feeding may be subject to negligible endogenous 5-HT tone (42)(43)(44).…”

Section: Coh-dpat-inducedhyperphagia: Reward Tolerance and Clinical mentioning

confidence: 99%

“…Furthermore, neither compound decreases hippocampal5-HTrelease, and bothWAY 100135 and WAY 100635 prevent the inhibition of 5-HT release induced by 8-OH-DPAT (40,82). Similarly,infeeding studies, WAY 100135 and WAY 100635 have no intrinsic effect on food intake but blockthehyperphagic actionof 8-OH-DPAT and other 5-HTlA receptor agonists (42)(43)(44). These data provide the first unequivocal evidence from antagonist studies that 8-OH-DPAT-induced feeding is mediated by 5-HT1, receptors.…”

Section: -Hta Receptor Antagonistsmentioning

confidence: 99%

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