We need to talk about the Warburg effect

DeBerardinis, Ralph J.; Chandel, Navdeep S.

doi:10.1038/s42255-020-0172-2

Cited by 603 publications

(441 citation statements)

References 20 publications

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“…Unfortunately, the pH/glycolysis/cancer relationships were completely absent from those discussions and disagreements. Since then, many different attempts and theories to explain the cause and role of the increased glycolysis of tumors have been and are still considered [ 19 ]. Nowadays, the historical limitations of past decades can be understood because the cause–effect relationships of pHi elevations in stimulating glycolysis were first considered during Warburg’s old age and mainly outside the cancer context [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Harguindey¹,

Alfarouk

Orozco³

et al. 2020

IJMS

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A brand new approach to the understanding of breast cancer (BC) is urgently needed. In this contribution, the etiology, pathogenesis, and treatment of this disease is approached from the new pH-centric anticancer paradigm. Only this unitarian perspective, based upon the hydrogen ion (H+) dynamics of cancer, allows for the understanding and integration of the many dualisms, confusions, and paradoxes of the disease. The new H+-related, wide-ranging model can embrace, from a unique perspective, the many aspects of the disease and, at the same time, therapeutically interfere with most, if not all, of the hallmarks of cancer known to date. The pH-related armamentarium available for the treatment of BC reviewed here may be beneficial for all types and stages of the disease. In this vein, we have attempted a megasynthesis of traditional and new knowledge in the different areas of breast cancer research and treatment based upon the wide-ranging approach afforded by the hydrogen ion dynamics of cancer. The concerted utilization of the pH-related drugs that are available nowadays for the treatment of breast cancer is advanced.

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Section: Introductionmentioning

confidence: 99%

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Harguindey¹,

Alfarouk

Orozco³

et al. 2020

IJMS

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“…Such a metabolic pattern is reminiscent of the peculiar setup of the energy metabolism in cancer cells, i.e. Warburg effect [103,104], where a pivotal role is played by the PI3K/AKT-SGK1/mTOR signaling cascade [10,105,106].…”

Section: Resultsmentioning

confidence: 99%

Drug repurposing against COVID-19: focus on anticancer agents

Ciliberto

Mancini

Paggi³

2020

J Exp Clin Cancer Res

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Background: The very limited time allowed to face the COVID-19 pandemic poses a pressing challenge to find proper therapeutic approaches. However, synthesis and full investigation from preclinical studies to phase III trials of new medications is a time-consuming procedure, and not viable in a global emergency, such as the one we are facing. Main Body: Drug repurposing/repositioning, a strategy effectively employed in cancer treatment, can represent a valid alternative. Most drugs considered for repurposing/repositioning in the therapy of the COVID-19 outbreak are commercially available and their dosage and toxicity in humans is well known, due to years (or even decades) of clinical use. This can allow their fast-track evaluation in phase II-III clinical trials, or even within straightforward compassionate use. Several drugs being re-considered for COVID-19 therapy are or have been used in cancer therapy. Indeed, virusinfected cells are pushed to enhance the synthesis of nucleic acids, protein and lipid synthesis and boost their energy metabolism, in order to comply to the "viral program". Indeed, the same features are seen in cancer cells, making it likely that drugs interfering with specific cancer cell pathways may be effective as well in defeating viral replication. Short Conclusion: To our knowledge, cancer drugs potentially suitable for facing SARS-CoV-2 infection have not been carefully reviewed. We present here a comprehensive analysis of available information on potential candidate cancer drugs that can be repurposed for the treatment of COIVD-19.

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“…Moreover, the availability of donor molecules for glycosylations, usually activated monosaccharides, strongly depend on the cellular metabolism (Lau et al, 2007). As the metabolic state of the cell is altered in cancer, this link between the cellular metabolism and the glycocalyx state directly hints at remodeling of the glycocalyx upon oncogenic events (Pavlova and Thompson, 2016;Deberardinis and Chandel, 2020). Indeed, many relations between tumor metabolism, the glycocalyx, and the cellular state have been uncovered, for example the key role of the mucin Muc1 in hypoxia survival (for a discussion of mucins, see section "The Glycocalyx Controls Cell Morphology") (Yin et al, 2007;Chaika et al, 2012).…”

Section: Biosynthesis Of Glycocalyx Componentsmentioning

confidence: 99%

The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation

Möckl

2020

Front. Cell Dev. Biol.

169

126

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All cells in the human body are covered by a dense layer of sugars and the proteins and lipids to which they are attached, collectively termed the "glycocalyx." For decades, the organization of the glycocalyx and its interplay with the cellular state have remained enigmatic. This changed in recent years. Latest research has shown that the glycocalyx is an organelle of vital significance, actively involved in and functionally relevant for various cellular processes, that can be directly targeted in therapeutic contexts. This review gives a brief introduction into glycocalyx biology and describes the specific challenges glycocalyx research faces. Then, the traditional view of the role of the glycocalyx is discussed before several recent breakthroughs in glycocalyx research are surveyed. These results exemplify a currently unfolding bigger picture about the role of the glycocalyx as a fundamental cellular agent.

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We need to talk about the Warburg effect

Cited by 603 publications

References 20 publications

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H+-Centered Anticancer Paradigm of the Late Post-Warburg Era

Drug repurposing against COVID-19: focus on anticancer agents

The Emerging Role of the Mammalian Glycocalyx in Functional Membrane Organization and Immune System Regulation

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