WE6.6 Does Nexobrid improve healing outcomes in treatment in adults with partial thickness burn compared to standard of care? A meta-analysis

Abstract

Aims Burns are usually associated with significant morbidity and mortality due to dysfunction and disfigurement. Non-fatal burns usually contribute to morbidity via burn wound infection, systemic sepsis, multiple organ failure, pneumonia etc. leading to prolonged hospitalization. The objective of this study is to present a systematic review of the role of enzymatic debridement in healing outcomes compared to standard of care (debridement and skin grafting) in adult patients with burns. Methods A systematic review of randomized controlled and case-control studies reporting and comparing healing outcomes of Nexobrid with the standard of care, published on Embase, Medline, PubMed, Google Scholar and Cochrane databases in the period from 1946 until August 2021 was performed. Relevant studies were extracted and analysed with the help of Review Manager. Results The database search identified thirteen articles that met inclusion criteria. A combined number of 441 patients were included. Nexobrid application average time was one day. The combined mean of total body treated mean surface was 6.5%. Studies investigating Nexobrid mention the combine average success of debridement of 82.8%. The forest plots favour the current evidence of Nexobrid shortens time from injury to intervention, reducing the need for surgery, hence shortening the length of hospital stay. Conclusions This systematic review provides the current results of Nexobrid usage for enzymatic debridement of partial thickness to deep dermal burns. Further randomized controlled trials or feasibility studies are warranted to open new horizons for this modality of burns treatment.