Weak association between the interleukin-8 rs4073 polymorphism and acute pancreatitis: a cumulative meta-analysis

Li, Yening; Bai, Jing; He, Bing; Wang, Nan; Wang, Haoran; Li, Dongliang

doi:10.1186/s12881-019-0861-4

Cited by 9 publications

(8 citation statements)

References 27 publications

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“…Secondly, emerging studies have shown that pancreatitis and IBD are diseases of immune dysregulation. Cytokine abnormalities, such as elevation of interleukin 1 β (IL-1 β ), IL-6, IL-8, and IL-10, are involved in pancreatitis and IBD [ 32 – 34 ]. Pancreatic tissue and gastrointestinal epithelial cells may share vulnerable cellular structures or target molecules [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review

Chen

Mao

et al. 2020

Gastroenterology Research and Practice

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Background/Objectives. This systematic review was conducted to investigate the association between pancreatitis and IBD. Methods. MEDLINE, Embase, and CENTRAL were systematically searched for correlative studies till 2 November 2019. RevMan5.3 was used to estimate relevance. Results. Three studies with 166008 participants were included. The risk of pancreatitis significantly increased in the patients with CD (OR, 3.40; 95% CI, 2.70-4.28; P<0.00001) and UC (OR, 2.49; 95% CI, 1.91-3.26; P<0.00001). Increased risks of CD (OR, 12.90; 95% CI, 5.15-32.50; P<0.00001) and UC (OR, 2.80; 95% CI, 1.00-7.86; P=0.05) were found in patients with chronic pancreatitis. As for patients with acute pancreatitis, there were significant association of CD (OR, 3.70; 95% CI, 1.90-7.60; P=0.0002), but were not UC. Conclusions. The evidence confirmed an association between pancreatitis and IBD. When pancreatitis patients have chronic diarrhea and mucus blood stool or IBD patients have repeated abdominal pain and weight loss, they should consult pancreatic and gastrointestinal specialists.

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Section: Discussionmentioning

confidence: 99%

Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review

Chen

Mao

et al. 2020

Gastroenterology Research and Practice

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“…Among all the cytokines, IL-8 stands out in the AP pathophysiology as it has been demonstrated to be significantly elevated during the development of AP, and the level was reported to be associated with the severity of AP [113]. Several studies have shown promising results in the early prediction of severe AP [114].…”

Section: Interleukin-8mentioning

confidence: 99%

Multifactorial Scores and Biomarkers of Prognosis of Acute Pancreatitis: Applications to Research and Practice

Silva-Vaz

Abrantes

Castelo‐Branco

et al. 2020

IJMS

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Acute pancreatitis (AP) is a severe inflammation of the pancreas presented with sudden onset and severe abdominal pain with a high morbidity and mortality rate, if accompanied by severe local and systemic complications. Numerous studies have been published about the pathogenesis of AP; however, the precise mechanism behind this pathology remains unclear. Extensive research conducted over the last decades has demonstrated that the first 24 h after symptom onset are critical for the identification of patients who are at risk of developing complications or death. The identification of these subgroups of patients is crucial in order to start an aggressive approach to prevent mortality. In this sense and to avoid unnecessary overtreatment, thereby reducing the financial implications, the proper identification of mild disease is also important and necessary. A large number of multifactorial scoring systems and biochemical markers are described to predict the severity. Despite recent progress in understanding the pathophysiology of AP, more research is needed to enable a faster and more accurate prediction of severe AP. This review provides an overview of the available multifactorial scoring systems and biochemical markers for predicting severe AP with a special focus on their advantages and limitations.

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“…Further studies have also highlighted that both pancreatitis and IBD share a common immune dysregulation and an altered cytokines expression, such as an abnormal elevation of IL-1β, IL-6, IL-8, and IL-10, thus supporting the susceptibility for IBD patients to develop pancreatic manifestations over time [ 42 , 43 , 44 ].…”

Section: Role Of Genetics In Pediatric Pancreatitis and Its Association With Ibdmentioning

confidence: 99%

Pancreatic Associated Manifestations in Pediatric Inflammatory Bowel Diseases

Cucinotta

Romano

Dipasquale

2021

Genes

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Inflammatory bowel diseases (IBDs) are chronic relapsing inflammatory conditions of the gastrointestinal tract, encompassing Crohn’s disease (CD), ulcerative colitis (UC) and inflammatory bowel disease unclassified (IBD-U). They are currently considered as systemic disorders determined by a set of genetic predispositions, individual susceptibility and environmental triggers, potentially able to involve other organs and systems than the gastrointestinal tract. A large number of patients experiences one or more extraintestinal manifestations (EIMs), whose sites affected are mostly represented by the joints, skin, bones, liver, eyes, and pancreas. Pancreatic abnormalities are not uncommon and are often underestimated, encompassing acute and chronic pancreatitis, autoimmune pancreatitis, exocrine pancreatic insufficiency and asymptomatic elevation of pancreatic enzymes. In most cases they are the result of environmental triggers. However, several genetic polymorphisms may play a role as precipitating factors or contributing to a more severe course. The aim of this paper is to provide an updated overview on the available evidence concerning the etiology, pathogenesis and clinical presentation of pancreatic diseases in IBD pediatric patients.

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Weak association between the interleukin-8 rs4073 polymorphism and acute pancreatitis: a cumulative meta-analysis

Cited by 9 publications

References 27 publications

Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review

Association between Inflammatory Bowel Disease and Pancreatitis: A PRISMA-Compliant Systematic Review

Multifactorial Scores and Biomarkers of Prognosis of Acute Pancreatitis: Applications to Research and Practice

Pancreatic Associated Manifestations in Pediatric Inflammatory Bowel Diseases

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