Weak Linkage in parC of Neisseria Gonorrhea: Identification of Mutation Prone Point that can Lead to Drug Resistance

Abstract

Gonorrhea is a significant sexually transmitted disease. Early initiation of treatment is important in the reduction of the onward transmission. Mutation of the pathogen is believed to be an important factor that can initiate drug resistance. In fluoroquinolone-resistant Neisseria gonorrhoeae, the amino acid mutations in the fluoroquinolone-resistant determining region (QRDR) of the parC gene are an important factor. Presently, prediction of protein nanostructure and function is a great challenge in the proteomics and structural genomics era. To identify the point vulnerable to mutate is a new trend to expand the knowledge on disorders in genomic and proteomic level of diseases. Here, the author performed a bioinformatic analysis to study the determine positions that trend to comply peptide motifs in the amino acid sequence of parC. To identify the weak linkage in parC, a new bioinformatic tool called GlobPlot was used.According to this work, the positions 1-11, 80-86, 107-120, 147-160, 217-226, 288-294, 584-597 are identified as the position resist to mutation. Based on this study, the weak linkages in the parC can be identified and generate information for the expectation of possible new mutations that can lead to failure of gonorrhea therapy. In addition, the results from this study provide information for further research on the diagnosis for mutants gonorrhea and new drug development.