Wearable Tape-Based Smart Biosensing Systems for Lactate and Glucose

Luo, Xian; Guo, Lei; Liu, Yiqun; Shi, Weihua; Gai, Weixin; Cui, Yue

doi:10.1109/jsen.2019.2959029

Cited by 24 publications

(14 citation statements)

References 27 publications

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“…In the same field of research, wearable adhesive tapes are an ideal sweat-based enzymatic biosensor, as they can be attached directly on skin, forming close contact with the epidermis, and are capable of detecting multiple biomarkers simultaneously. Luo et al fabricated an electrochemical sensor on adhesive tapes for detection of glucose and lactate in sweat [ 105 ]. The sensor was prepared by heating and printing carbon graphite ink on adhesive tape to develop working as well as counter electrodes with Ag/AgCl as reference electrode.…”

Section: Recent Developments In Various Biological Fluid-based Glucos...mentioning

confidence: 99%

“…Here, the interaction of Prussian blue with H 2 O 2 and immobilization of lactate oxidase or glucose oxidase on the working electrode control output current during detection. The device was reported to have a detection time of 5 min with a linear range of 2.38 mM to 14.29 mM and an LOD of 3.84 μM [ 105 ].…”

Section: Recent Developments In Various Biological Fluid-based Glucos...mentioning

confidence: 99%

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Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review

Reddy

Agarwal

et al. 2022

Nanomaterials

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Biosensors have potentially revolutionized the biomedical field. Their portability, cost-effectiveness, and ease of operation have made the market for these biosensors to grow rapidly. Diabetes mellitus is the condition of having high glucose content in the body, and it has become one of the very common conditions that is leading to deaths worldwide. Although it still has no cure or prevention, if monitored and treated with appropriate medication, the complications can be hindered and mitigated. Glucose content in the body can be detected using various biological fluids, namely blood, sweat, urine, interstitial fluids, tears, breath, and saliva. In the past decade, there has been an influx of potential biosensor technologies for continuous glucose level estimation. This literature review provides a comprehensive update on the recent advances in the field of biofluid-based sensors for glucose level detection in terms of methods, methodology and materials used.

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Section: Recent Developments In Various Biological Fluid-based Glucos...mentioning

confidence: 99%

Section: Recent Developments In Various Biological Fluid-based Glucos...mentioning

confidence: 99%

Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review

Reddy

Agarwal

et al. 2022

Nanomaterials

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“…Screen-printing is one of the most popular methods for electrochemical sensor fabrication due to the diversity of inks, ability to print onto a wide variety of substrates in almost any pattern, its low-cost and ease of mass manufacture [ 89 ]. As such, there have been examples reported utilising screen-printing to fabricate lactate sensors on fabric [ 90 ], tape [ 91 ], microplates [ 92 ], polyester substrates [ 93 ], and temporary tattoo transfer paper [ 54 ]. One key parameter that could be problematic for the transition of these elements to healthcare is the sample volume required.…”

Section: Current Non-invasive Technology For Lactate Measurements mentioning

confidence: 99%

Evaluating the Possibility of Translating Technological Advances in Non-Invasive Continuous Lactate Monitoring into Critical Care

Crapnell

Tridente

Banks

et al. 2021

Sensors

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Lactate is widely measured in critically ill patients as a robust indicator of patient deterioration and response to treatment. Plasma concentrations represent a balance between lactate production and clearance. Analysis has typically been performed with the aim of detecting tissue hypoxia. However, there is a diverse range of processes unrelated to increased anaerobic metabolism that result in the accumulation of lactate, complicating clinical interpretation. Further, lactate levels can change rapidly over short spaces of time, and even subtle changes can reflect a profound change in the patient’s condition. Hence, there is a significant need for frequent lactate monitoring in critical care. Lactate monitoring is commonplace in sports performance monitoring, given the elevation of lactate during anaerobic exercise. The desire to continuously monitor lactate in athletes has led to the development of various technological approaches for non-invasive, continuous lactate measurements. This review aims firstly to reflect on the potential benefits of non-invasive continuous monitoring technology within the critical care setting. Secondly, we review the current devices used to measure lactate non-invasively outside of this setting and consider the challenges that must be overcome to allow for the translation of this technology into intensive care medicine. This review will be of interest to those developing continuous monitoring sensors, opening up a new field of research.

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“…14−38 The lactate in sweat undergoes an enzymatic redox reaction to generate a mediated change in current, whose magnitude directly correlates with the amount of lactate. Other techniques that could quantify sweat lactate concentrations include chemiluminescence, 39 electrochemiluminescence, 38,41 and chromatography. 18,42 Electrochemical lactate sensing platforms based on various biological fluids offer a higher sensitivity and linear dynamic range (LDR) and a lower limit of detection (LOD, ∼nM range), as compared to their colorimetric counterparts.…”

mentioning

confidence: 99%

“…3,43−45 Moreover, electrical signals generated from electrochemical sensors can directly interface with traditional analog electronics. The skin-interfacing electrodes of these electrochemical sweat lactate sensors are fabricated using photol i t h o g r a p h y , 1 4 − 1 6 , 1 9 , 3 8 s c r e e n p r i n ting, 17,18,24,25,[27][28][29]31,32,34,35,38,46,47 sputter coating, 20,31 inkjet printing, 21 wax printing, 26 or direct stamping 33 techniques. These electrodes could be printed on sheets of either polyimide (PI), 14,15,19,25,29,35,46,47 polyethylene terephthalate, 16,24,27,28,37 polyethylene naphthalate, 17,22 plastic, 18,32 polycarbonate, 21 polyester, 34 or tattoo paper.…”

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confidence: 99%

Wireless Wearable Electrochemical Sensing Platform with Zero-Power Osmotic Sweat Extraction for Continuous Lactate Monitoring

et al. 2022

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Wearable and wireless monitoring of biomarkers such as lactate in sweat can provide a deeper understanding of a subject's metabolic stressors, cardiovascular health, and physiological response to exercise. However, the state-of-the-art wearable and wireless electrochemical systems rely on active sweat released either via high-exertion exercise, electrical stimulation (such as iontophoresis requiring electrical power), or chemical stimulation (such as by delivering pilocarpine or carbachol inside skin), to extract sweat under lowperspiring conditions such as at rest. Here, we present a continuous sweat lactate monitoring platform combining a hydrogel for osmotic sweat extraction, with a paper microfluidic channel for facilitating sweat transport and management, a screen-printed electrochemical lactate sensor, and a custom-built wireless wearable potentiostat system. Osmosis enables zeroelectrical power sweat extraction at rest, while continuous evaporation at the end of a paper channel allows long-term sensing from fresh sweat. The positioning of the lactate sensors provides near-instantaneous sensing at low sweat volume, and the custom-designed potentiostat supports continuous monitoring with ultra-low power consumption. For a proof of concept, the prototype system was evaluated for continuous measurement of sweat lactate across a range of physiological activities with changing lactate concentrations and sweat rates: for 2 h at the resting state, 1 h during mediumintensity exercise, and 30 min during high-intensity exercise. Overall, this wearable system holds the potential of providing comprehensive and long-term continuous analysis of sweat lactate trends in the human body during rest and under exercising conditions.

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Wearable Tape-Based Smart Biosensing Systems for Lactate and Glucose

Cited by 24 publications

References 27 publications

Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review

Recent Advancement in Biofluid-Based Glucose Sensors Using Invasive, Minimally Invasive, and Non-Invasive Technologies: A Review

Evaluating the Possibility of Translating Technological Advances in Non-Invasive Continuous Lactate Monitoring into Critical Care

Wireless Wearable Electrochemical Sensing Platform with Zero-Power Osmotic Sweat Extraction for Continuous Lactate Monitoring

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