Weight bearing does not contribute to the development of osteonecrosis of the femoral head

Okazaki, Shunichiro; Nagoya, Satoshi; Tateda, Kenji; Katada, Ryuichi; Mizuo, Keisuke; Watanabe, Satoshi; Yamashita, Toshihiko; Matsumoto, Hiroshi

doi:10.1111/j.1365-2613.2012.00836.x

Cited by 23 publications

(19 citation statements)

References 18 publications

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“…We observed empty lacunae within the necrotic bone trabeculae and bone marrow cells including adipocytic necrosis in most areas of the femoral head in the alcohol group; results were similar to those observed in corticosteroid‐induced ONFH model treated with corticosteroids after the administration of a TLR4 ligand, LPS (Okazaki et al . ). In particular, histological examination of the epiphysis showed osteocytic death and necrotic bone marrow with or without appositional bone.…”

Section: Discussionmentioning

confidence: 97%

Experimental rat model for alcohol‐induced osteonecrosis of the femoral head

Okazaki

Nagoya

Tateda

et al. 2013

Int J Experimental Path

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Alcohol-induced osteonecrosis of the femoral head (ONFH) is observed in alcohol abusers and patients with alcoholic fatty liver disease. It has been reported that Toll-like receptor 4 (TLR4) signalling plays a crucial role in the pathogenesis of alcoholic fatty liver disease. We previously reported a corticosteroid-induced ONFH rat model, and suggested that TLR4 signalling contributes to the pathogenesis of ONFH. Thus, it is thought that the pathogenesis of alcohol-induced ONFH is probably similar to that of corticosteroid-induced ONFH. The aim of this study was to develop a new animal model for alcohol-induced ONFH and to evaluate the relationship between the pro-inflammatory response via TLRs and the development of ONFH in rats. Male Wistar rats were fed a Lieber–DeCarli liquid diet containing 5% ethanol (experimental group) or dextran (control group) for 1–24 weeks. Histopathological and biochemical analyses were performed. Feeding the ethanol-containing liquid diet resulted in the development of ONFH with hepatic steatosis, hepatic dysfunction and hyperlipidaemia, whereas feeding the dextran-containing diet did not cause ONFH. However, we could not recognize any relationship between the pro-inflammatory response via TLR4 and the development of alcohol-induced ONFH. Thus in this study we have developed a new rat model for alcohol-induced ONFH based on the feeding of an ethanol liquid diet. ONFH was observed within seven days from the start of feeding with 5% ethanol-containing liquid diet. Although this was linked to hepatic steatosis, a TLR4 association was not a feature of this model.

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Section: Discussionmentioning

confidence: 97%

Experimental rat model for alcohol‐induced osteonecrosis of the femoral head

Okazaki

Nagoya

Tateda

et al. 2013

Int J Experimental Path

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“…NWB therapy did not prevent ONFH in rats in a study by Okazaki et al (21), which also clarified the role of weight bearing in the development of ONFH. In the study, an ONFH model was established in non-weight-bearing and weight-bearing groups of rats following lipopolysaccharide and methylprednisolone stimulation.…”

Section: Nwb Therapymentioning

confidence: 91%

Summary of the various treatments for osteonecrosis of the femoral head by mechanism: A review

Wang

Peng

2014

Experimental and Therapeutic Medicine

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Osteonecrosis of the femoral head (ONFH), also known as femoral head avascular necrosis, is a pathological state with a number of possible etiologies including steroid administration, alcohol abuse, traumatic events, vascular injury and idiopathic origins. ONFH causes a reduction in the vascular supply to the subchondral bone of the femoral head, which results in osteocyte death and the collapse of the articular surface. Treatments for ONFH include non-weight-bearing therapy, physical support, the promotion of osteoclast apoptosis, and the reduction of osteoblast and osteocyte apoptosis. The aim of the present review was to summarize the treatments for ONFH by mechanism from a new perspective and to describe the condition with an emphasis on treatment options.

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“…Whereas this proved useful in a variety of other orthopedic diseases, no advantage could be shown for non-weight-bearing therapy as the only treatment, even in early-stage nontraumatic ON of etiologies other than ALL. [23][24][25] In children with ALL, it has not been evaluated or proven to be beneficial for the treatment of ON.…”

Section: Non-weight-bearing Therapymentioning

confidence: 99%

Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge

et al. 2017

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Osteonecrosis (ON) represents one of the most common and debilitating sequelae of antileukemic treatment in children and adolescents with acute lymphoblastic leukemia (ALL). Systematic screening strategies can focus on early detection and intervention to prevent ON from progressing to stages associated with pain and functional impairment.These strategies hold promise for reducing ON-associated morbidity without the risk of impairing leukemia control. Herein, we critically reviewed clinical data on pharmacological, nonpharmacological/nonsurgical, and surgical (including cellular) treatment options for ON, which are covered in the literature and/or are conceivable based on the supposed underlying ON pathophysiology. Prevention of ON progression is of paramount importance, and attempts seem to be more effective in early (precollapse) disease status than in late-stage (collapse) ON. Based on the results of ongoing prospective magnetic resonance imaging screening studies, which will hopefully identify those patients with a high risk of ON progression and debilitating sequelae, prospective interventional studies are urgently needed. Although there is still a lack of high-quality studies, based on currently available data, core decompression surgery combined with cellular therapies (eg, employing mesenchymal stem cells) appears most promising for preventing joint infraction in children at high risk of developing late-stage ON.

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Weight bearing does not contribute to the development of osteonecrosis of the femoral head

Cited by 23 publications

References 18 publications

Experimental rat model for alcohol‐induced osteonecrosis of the femoral head

Experimental rat model for alcohol‐induced osteonecrosis of the femoral head

Summary of the various treatments for osteonecrosis of the femoral head by mechanism: A review

Osteonecrosis in children and adolescents with acute lymphoblastic leukemia: a therapeutic challenge

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