Weight change during middle age and risk of stroke and coronary heart disease: The Japan Public Health Center–based Prospective Study

Kisanuki, Koichi; Muraki, Isao; Yamagishi, Kazumasa; Kokubo, Yoshihiro; Saito, Isao; Yatsuya, Hiroshi; Sawada, Norie; Iso, Hiroyasu; Tsugane, Shoichiro

doi:10.1016/j.atherosclerosis.2021.02.017

Cited by 14 publications

(15 citation statements)

References 21 publications

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“…In a prospective cohort study in Japan (N=74 928 adults), weight gain during midlife was associated with an increased risk of stroke in females (aHR, 1.61 [95% CI, 1.36–1.92] for weight gain ≥5 kg) but not in males. 155…”

Section: Nutritionmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2022

Circulation

3,787

2,336

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Background: The American Heart Association, in conjunction with the National Institutes of Health, annually reports the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health. The Statistical Update presents the latest data on a range of major clinical heart and circulatory disease conditions (including stroke, congenital heart disease, rhythm disorders, subclinical atherosclerosis, coronary heart disease, heart failure, valvular disease, venous disease, and peripheral artery disease) and the associated outcomes (including quality of care, procedures, and economic costs). Methods: The American Heart Association, through its Statistics Committee, continuously monitors and evaluates sources of data on heart disease and stroke in the United States to provide the most current information available in the annual Statistical Update. The 2022 Statistical Update is the product of a full year’s worth of effort by dedicated volunteer clinicians and scientists, committed government professionals, and American Heart Association staff members. This year’s edition includes data on the monitoring and benefits of cardiovascular health in the population and an enhanced focus on social determinants of health, adverse pregnancy outcomes, vascular contributions to brain health, and the global burden of cardiovascular disease and healthy life expectancy. Results: Each of the chapters in the Statistical Update focuses on a different topic related to heart disease and stroke statistics. Conclusions: The Statistical Update represents a critical resource for the lay public, policymakers, media professionals, clinicians, health care administrators, researchers, health advocates, and others seeking the best available data on these factors and conditions.

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Section: Nutritionmentioning

confidence: 99%

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Tsao¹,

Aday²,

Almarzooq³

et al. 2022

Circulation

3,787

2,336

View full text Add to dashboard Cite

show abstract

“…risk of CVD events. For example, some studies showed increased CVD risk with weight gain but not weight loss [22][23][24][25][26][27] , some studies with weight loss but not weight gain [28][29][30][31][32][33] , some studies with both weight gain and weight loss [34][35][36][37][38][39][40] , and some studies with neither weight gain nor weight loss [41][42][43][44] . In addition to the inconsistent results, most studies assessed weight change within a short period that might not be similar to weight change within a long period.…”

Section: Covariatesmentioning

confidence: 99%

Weight Change Since Age 20 and the Risk of Cardiovascular Disease Mortality: A Prospective Cohort Study

Arafa

Kokubo

Sheerah

et al. 2022

JAT

Self Cite

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Aim: Weight change could have many health outcomes. This study aimed to investigate the association between weight change and mortality risk due to total cardiovascular disease (CVD), ischemic heart disease (IHD), and stroke among Japanese. Methods: We used Suita Study data from 4,746 people aged 30-79 years in this prospective cohort study. Weight change was defined as the difference between baseline weight and weight at age 20. We used Cox proportional hazards models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) of total CVD, IHD, and stroke mortality for 1) participants with a weight change (＞10, 5 to 10, -5 to -10, and ＜-10 kg) compared to those with stable weight (-4.9 to 4.9 kg) and 2) participants who moved from one body mass index category (underweight, normal weight, or overweight) to another compared to those with normal weight at age 20 and baseline. Results: Within a median follow-up period of 19.9 years, the numbers of total CVD, IHD, and stroke mortality were 268, 132, and 79, respectively. Weight loss of ＞10 kg was associated with the increased risk of total CVD mortality 2.07 (1.29, 3.32) and stroke mortality 3.02 (1.40, 6.52). Moving from normal weight at age 20 to underweight at baseline was associated with the increased risk of total CVD, IHD, and stroke mortality: 1.76 (1.12, 2.77), 2.10 (1.13, 3.92), and 2.25 (1.05, 4.83), respectively. Conclusion: Weight loss, especially when moving from normal to underweight, was associated with the increased risk of CVD mortality.

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“…Weight was measured using the OmronTM HN-286 scale, and height was measured using the SecaTM213 stadiometer. Weight change was calculated by subtracting weight at baseline from that at the 4-year follow-up survey (weight difference between in Wave 3 and Wave 1) and was classified into the following 5 categories: loss ≥5 kg; loss 2–5 kg; stable (change ≤2 kg); gain 2–5 kg; and gain ≥5 kg according to previous study [ 9 ].…”

Section: Methodsmentioning

confidence: 99%

“…Weight change in early to middle age was reportedly as-Obes Facts 2022;15:694-702 DOI: 10.1159/000526419 sociated with an increased risk of CVD [7,8]. Several studies also examined the associations between short-and long-term weight change during middle age and CVD, but the findings have shown inconclusive and inconsistent associations [9][10][11]. Diverse findings could be due to differences in overweight/obesity prevalence, lengths of the weight-change intervals, and the time periods between weight changes and events.…”

Section: Introductionmentioning

confidence: 99%

Weight Change over 4 Years and Risk of Cardiovascular Diseases in China: The China Health and Retirement Longitudinal Study

Zheng

2022

Obes Facts

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Introduction: Previous studies had reported the impact of weight changes in middle age on the incidence of cardiovascular disease (CVD), but the results were inconsistent. In present study, we aimed to investigated the impact of a 4-year weight change on the risk of CVD in middle-aged and elderly Chinese individuals. Methods: Using nationally representative data from the China Health and Retirement Longitudinal Study, 7,530 participants (age: 58.2 ± 8.9 years) were included. Weight change was calculated by subtracting weight at baseline from that at 4-year follow-up. Weight change over 4 years was divided into five categories (loss ≥5 kg; loss 2–5 kg; stable (change ≤ 2 kg); gain 2–5 kg; and gain ≥5 kg). Results: During the follow-up period, a total of 758 respondents experienced CVD (including 319 stroke and 477 cardiac events). The multivariable ORs of CVD for gain ≥5 kg compared to stable weight (change ≤2 kg) was 1.50 (95% CI, 1.14–1.97) versus 1.41(1.09-1.83) for losing ≥5 kg. Multivariable-adjusted logistic regression model with restricted cubic splines showed a U-shaped association between weight change and the risk of CVD (p for nonlinearity <0.001). The significant associations did not change in subgroup and sensitivity analysis. Weight change was also associated with higher risk of stroke and cardiac events. Conclusion: Weight changes (weight gain or loss more than 5kg) during middle age was associated with an increased risk of CVD in middle-aged and elderly Chinese individuals.

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Weight change during middle age and risk of stroke and coronary heart disease: The Japan Public Health Center–based Prospective Study

Cited by 14 publications

References 21 publications

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Heart Disease and Stroke Statistics—2022 Update: A Report From the American Heart Association

Weight Change Since Age 20 and the Risk of Cardiovascular Disease Mortality: A Prospective Cohort Study

Weight Change over 4 Years and Risk of Cardiovascular Diseases in China: The China Health and Retirement Longitudinal Study

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