Weight reduction improves immune system and inflammatory cytokines in obese asthmatic patients

Al-Sharif, Fadwah M; El-Kader, Shehab M Abd; Neamatallah, Ziyad; Alkhateeb, Afnan M.

doi:10.4314/ahs.v20i2.44

Cited by 11 publications

(12 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 12 studies (62%) 10,[27][28][29][30][31][32][33][34][35][36][37] showed that AT induced some change in the immune system inflammatory response, while 9 studies (38%) [38][39][40][41][42][43][44][45] did not show any change in the immune system. In complement, other general benefits were observed such as improvements in the aerobic fitness (10 studies), health-related quality of life (7 studies), clinical control (2 studies), reduction of symptoms of asthma (6 studies), and decrease of airways hyperresponsiveness (2 studies) (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies have shown that AT induces a modulation of the immune system 10,[27][28][29][30][31][32][33][34][35][36][37] . In this sense, the present study speculates on two categories of asthmatics, i) those who practice regular exercise or are trained; ii) and those who are untrained or sedentary.…”

Section: Possible Protective Pathways Against Covid-19 Presented By S...mentioning

confidence: 99%

See 1 more Smart Citation

People with asthma: care during the COVID-19 pandemic and the importance of regular exercise for the immune system

Silva¹

2022

Motriz: rev. educ. fis.

View full text Add to dashboard Cite

To show the possible immunologic pathways of protection for asthmatics against infection of Covid-19 through the capacity of recognition and cytotoxicity to eliminate pathogens improved by regular exercise aerobic. Methods:The bibliographic search was conducted on the following databases: Pubmed/Medline, Scielo, and Scholar Google from 2020 to 2021. The following keywords and Boolean operators were used: asthma, aerobic training (AT), immune system, and Covid-19. Results: After the screening, 349 were initially found, after evaluation only 20 studies had all criteria. Twelve studies showed that AT induces changes in the immune system with a reduction of inflammation. In complement, the literature showed an innate pathway that improves immune function against COVID-19 by reducing angiotensin-converting enzyme 2 (ACE2) in the lung, which seems to hinder the multiplication of the COVID-19 virus in the lung. Apparently, asthmatics patients are less susceptible to respiratory infection caused by COVID-19 because they have low levels of ACE2. Furthermore, trained asthmatics showed a lower risk of infection for SARS-CoV-2. Conclusion:The findings reported that asthmatics people can benefit from AT, and these individuals seem not to be a risk group for covid-19 because they have low levels of ACE2 protein. Taken together, this review reinforces the importance of asthmatic patients be physically active throughout their lifetime, but specially during the pandemic to prevent contamination by SARS-CoV-2.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Possible Protective Pathways Against Covid-19 Presented By S...mentioning

confidence: 99%

People with asthma: care during the COVID-19 pandemic and the importance of regular exercise for the immune system

Silva¹

2022

Motriz: rev. educ. fis.

View full text Add to dashboard Cite

show abstract

“…A total of nine studies were identified, including six RCTs [97][98][99][100][101][102] and three single group pre-post studies [103][104][105] (Table 1). The number of participants across the studies ranged from 27 to 330 participants.…”

Section: Study Characteristicsmentioning

confidence: 99%

Combined Lifestyle Interventions in the Prevention and Management of Asthma and COPD: A Systematic Review

Born,

Bhadra,

D’Souza

et al. 2024

Nutrients

View full text Add to dashboard Cite

(1) Background: A healthy lifestyle has a protective role against the onset and management of asthma and chronic obstructive pulmonary disease (COPD). Therefore, combined lifestyle interventions (CLIs) are a potentially valuable prevention approach. This review aims to provide an overview of existing CLIs for the prevention and management of asthma or COPD. (2) Methods: A systematic literature search was conducted using PubMed, EMBASE, and PsycInfo. Studies were included if CLIs targeted at least two lifestyle factors. (3) Results: Among the 56 included studies, 9 addressed asthma and 47 addressed COPD management, with no studies focusing on prevention. For both conditions, the most prevalent combination of lifestyle targets was diet and physical activity (PA), often combined with smoking cessation in COPD. The studied CLIs led to improvements in quality of life, respiratory symptoms, body mass index/weight, and exercise capacity. Behavioural changes were only measured in a limited number of studies and mainly showed improvements in dietary intake and PA level. (4) Conclusions: CLIs are effective within asthma and COPD management. Next to optimising the content and implementation of CLIs, these positive results warrant paying more attention to CLIs for persons with an increased risk profile for these chronic respiratory diseases.

show abstract

“…In the last few decades, the prevalence of obesity and allergic diseases is increasing worldwide in adults and children (1)(2)(3)(4). Several experimental and clinical studies suggested relationships between obesity, allergies and asthma, however the underlying mechanisms linking these diseases are still not well understood (5)(6)(7)(8). Vitamin D is an important regulator of the immune system, and low vitamin D status has been associated with several immune-mediated diseases such as multiple sclerosis, inflammatory bowel disease, and allergic asthma (9-13).…”

Section: Introductionmentioning

confidence: 99%

Associations between vitamin D, immunoglobulin E concentrations, and obesity

Castillo¹,

Hagemann

Hoffmann

et al. 2023

Front. Nutr.

View full text Add to dashboard Cite

The prevalence of allergies and obesity has been increased in parallel. Low vitamin D [25(OH)D] levels have been linked to both higher body mass index (BMI) and allergies. Since the activation of the 25(OH)D receptor inhibits IgE production and 25(OH)D influences the IgE response specifically, we tested the hypothesis that circulating 25(OH)D concentrations are negatively related to circulating allergen-specific IgE concentrations distinctly in a large adult population-based study cohort. Moreover, we studied VDR gene expression in paired biopsies of abdominal subcutaneous (SAT) and visceral adipose tissue (VAT). We investigated whether magnetic resonance imaging-estimated visceral (VFM) and subcutaneous fat mass (SFM) are related to 25(OH)D levels. We found gender differences in circulating 25(OH)D and IgE concentrations. Participants with obesity showed lower 25(OH)D concentrations and higher IgE concentrations were detected in women only. Interestingly, participants with high levels of 25(OH)D are leaner and have improved glucose metabolism. In women, 25(OH)D correlate significant with VFM and SFM. VDR expression is significantly higher expressed in VAT and is positive associated with circulating 25(OH)D concentration. There was no association between serum IgE and 25(OH)D in the entire cohort. Based on these data, we could confirm that low levels of 25(OH)D are linked to higher BMI but could not prove our hypothesis because there is no relationship between 25(OH)D and IgE in adults. Women with higher BMI tend to have higher IgE levels what may have clinical relevance. The association between obesity and circulating 25(OH)D/IgE is not straightforward, and further knowledge is needed.

show abstract

Weight reduction improves immune system and inflammatory cytokines in obese asthmatic patients

Cited by 11 publications

References 34 publications

People with asthma: care during the COVID-19 pandemic and the importance of regular exercise for the immune system

People with asthma: care during the COVID-19 pandemic and the importance of regular exercise for the immune system

Combined Lifestyle Interventions in the Prevention and Management of Asthma and COPD: A Systematic Review

Associations between vitamin D, immunoglobulin E concentrations, and obesity

Contact Info

Product

Resources

About