Welcome to Seminars in Thrombosis &amp; Hemostasis 2023

Favaloro, Emmanuel J.

doi:10.1055/s-0042-1759685

Semin Thromb Hemost

2023

DOI: 10.1055/s-0042-1759685

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Welcome to Seminars in Thrombosis & Hemostasis 2023

Emmanuel J. Favaloro

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2024

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“…Finally, given that this issue is publishing in 2024, we have also included a few items of historical interest. As previously noted, [12][13][14][15][16][17][18] STH is celebrating 50 years of publishing this year. Each issue of 2024 will therefore include a paper republished from the "archives," as well as an accompanying Commentary.…”

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confidence: 91%

Contact Activation: Where Thrombosis and Hemostasis Meet on a Foreign Surface, Plus a Mini-editorial Compilation (“Part XVI”)

Vu,

McCarty,

Favaloro

2024

Semin Thromb Hemost

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Welcome to the latest issue of Seminars in Thrombosis and Hemostasis (STH); this issue primarily devoted to highlighting the contact activation pathway of coagulation. Developed to provide an overview of the current body of knowledge around the roles, applications, and new knowledge of the contact pathway, this compilation serves as an appetizer for the modern thrombosis and inflammation enthusiast.This issue begins with a contribution from Dr. Shamanaev and colleagues, who start at the top of the coagulation cascade and examine the structure and function of coagulation factor XII (FXII), a serine protease, as it relates to disease. 1 The zymogen FXII can convert prekallikrein and factor XI to the proteases kallikrein and activated FXI (FXIa); this process is instrumental in certain disease states to facilitate abnormal incidents like angioedema and thrombotic events. Drawing on its homolog-pro-hepatocyte growth factor activator-a combination of isolated domains was selected for replacement and then assessed for resulting FXII activation and FXIIa activity. This review acts to establish the circulating closed and bound open conformations of FXII that are resistant to and expedite activation, respectively. Such information may prove integral as we proceed to unravel the complexities of key pathological processes in the quest to ultimately develop treatments for thromboinflammatory disorders.

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mentioning

confidence: 91%

Contact Activation: Where Thrombosis and Hemostasis Meet on a Foreign Surface, Plus a Mini-editorial Compilation (“Part XVI”)

Vu,

McCarty,

Favaloro

2024

Semin Thromb Hemost

View full text Add to dashboard Cite

show abstract

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Welcome to Seminars in Thrombosis & Hemostasis 2023

Cited by 1 publication

References 4 publications

Contact Activation: Where Thrombosis and Hemostasis Meet on a Foreign Surface, Plus a Mini-editorial Compilation (“Part XVI”)

Contact Activation: Where Thrombosis and Hemostasis Meet on a Foreign Surface, Plus a Mini-editorial Compilation (“Part XVI”)

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