The inter- and intra-state migration of American families with work-disabled members is a neglected area of empirical study. Longitudinal migration and health status data from the 1996 Panel of the Survey of Income and Program Participation (SIPP) are merged with state-level welfare policy indicators to investigate migration behavior under welfare reform’s emphasis on requiring work and encouraging reliance on social support networks. We use a nested discrete-choice event history model that incorporates the departure decision and interstate destination choice in a single model that tests the effects of state-level welfare policy and economic opportunity characteristics, with state fixed effects, plus family sociodemographic characteristics and social networks, as the basis for comparing migration of families with and without work disabilities. The results show that although families with disabilities and illnesses are less likely to migrate than other families generally, they are “pushed” to migrate if they live in states that do not exempt them from TANF activities requirements. Furthermore, in-migration is inhibited by stringent state welfare illness exemption rules and high state unemployment rates. Intrastate migration is more likely among families who received family and community social support, regardless of work-disability status. Copyright Springer Science+Business Media B.V. 2006Migration, Work disability, TANF illness exemptions, Social support,