Well-differentiated liposarcoma primary from thymic stroma: Case report and literature review

Furlan, Karina; Miller, Ira; Rohra, Prih; Mir, Fatima; González, Fernando; Gattuso, Paolo

doi:10.1016/j.yexmp.2020.104517

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…The most common subtype is the well-differentiated type, which has a favorable prognosis, while the dedifferentiated subtype is associated with a poor prognosis [ 2 ]. In this study, the patient was diagnosed with the well-differentiated subtype, and our literature review showed that out of 13 patients with the same subtype [ 1 , 6 – 8 , 10 , 16 , 17 , 19 ], ten had no recurrence after surgical intervention [ 6 – 8 , 10 , 17 , 19 ]. This finding indicates a positive prognosis for this subtype.…”

Section: Discussionmentioning

confidence: 96%

“…Ultimately, a core needle or surgical biopsy is performed to establish a definitive diagnosis [ 19 ]. In our literature, 11 patients were found to have tumors of a giant size, equal to or greater than 20 cm [ 1 , 3 , 5 – 8 , 10 , 16 , 19 ], while 13 had tumors of a relatively large size, equal to or greater than 10 cm [ 2 , 10 – 14 , 17 – 19 ], and 4 had small tumors, less than 10 cm in size[ 2 , 9 , 19 ]. Our case, on the other hand, featured a giant tumor that measured 25 cm.…”

Section: Discussionmentioning

confidence: 99%

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Mediastinal liposarcoma: a case report and review of the literature

Ataya,

Nahle,

Hamdar

et al. 2023

J Med Case Reports

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Background Mediastinal Liposarcoma (ML) is an exceedingly rare neoplasm, accounting for less than 1% of all liposarcomas. Surgical resection is the most effective therapeutic modality, while adjuvant radiation therapy may be recommended for unresectable tumors. Case presentation This case report presents a rare case of a 52-year-old Syrian male patient with well-differentiated mediastinal liposarcoma (ML) who presented with exertional dyspnea, cough, and weight loss. Imaging studies revealed a large tumor causing extrinsic compression on the right lung, as well as compression of the heart and great vessels. CT-guided biopsy confirmed a diagnosis of well-differentiated liposarcoma, and the patient underwent surgical resection. The patient had a rapid postoperative recovery and was discharged on the fourth day post-operation, displaying an excellent postoperative status. The patient was followed up for 3 months postoperatively with no recurrence. Conclusion This report highlights the significance of incorporating ML into the differential diagnosis of mediastinal masses, particularly in individuals presenting with exertional dyspnea and weight loss. Furthermore, this report provides a comprehensive review of previously reported cases of ML in the medical literature.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Mediastinal liposarcoma: a case report and review of the literature

Ataya,

Nahle,

Hamdar

et al. 2023

J Med Case Reports

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“…It should be mentioned that only 8 historical WDLs (6.8%) were analyzed by FISH, including 6 MDM2 -amplified cases, 1 case with equivocal MDM2 -FISH results, and 1 CPM -nonamplified case ( 10 , 12 , 20 , 31 – 34 ). In our study, all 18 tested WDLs were 12q13-15 amplified, including 17 MDM2 -amplified cases and 1 FRS2- amplified/ MDM2- nonamplified/ CDK4- nonamplified tumor (case 4).…”

Section: Discussionmentioning

confidence: 99%

Primary intrathoracic liposarcomas: A clinicopathologic and molecular study of 43 cases in one of the largest medical centers of China

Xie

Jing²,

Zhao³

et al. 2022

Front. Oncol.

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IntroductionPrimary intrathoracic liposarcoma is extremely rare, and most published series lack genetic analyses. The aim of our study is to better understand the clinicopathologic and genetic features of these rare lesions.Materials and methodsForty-three primary intrathoracic liposarcomas were identified and most cases were analyzed by systematic genetic studies, including fluorescence in situ hybridization (FISH), whole-exome sequencing (WES), and Sanger sequencing.ResultsThis series included 27 males and 16 females (ratios, 1.68:1) aged 24-73 years (median, 53 years). Tumors mainly occurred in the mediastinum (n=23, 53.5%), followed by pleural cavity (n=16, 37.2%) and lung (n=4, 9.3%). The study included 21 well-differentiated liposarcomas (WDLs), 19 dedifferentiated liposarcomas (DDLs), 2 myxoid pleomorphic liposarcomas (MPLs) and 1 pleomorphic liposarcoma (PL), without identification of myxoid liposarcoma. FISH analysis identified MDM2 amplification in 17 of 18 WDLs (94.4%) and all DDLs (16/16, 100.0%). The MDM2-nonamplified WDL was CDK4-nonamplified but FRS2-amplified. WES and Sanger sequencing found somatic TP53 mutation in the 2 MPLs. Follow-up information was available for 33 of 38 cases (86.8%). Thirteen patients (39.4%) showed no evidence of disease, 10 patients (30.3%) were alive with disease, and 8 patients (24.2%) died of disease. Fourteen cases developed recurrence and 1 with metastasis.ConclusionsWDL/DDL was the overwhelming subtype in this location, followed by MPL and PL. Analysis of the FRS2 gene, in combination with MDM2 and other genes of 12q13-15, may more precisely characterize WDL/DDLs. MPL is the most fatal subtype of this site. Further studies are needed to explore the role of TP53 in the pathogenesis of MPL.

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“…It is characterized by asymptomatic soft tissue masses that can occur throughout the body, with subcutaneous lipomas being more common. Ultrasound, computed tomography (CT), and magnetic resonance imaging (MRI) are important methods for its diagnosis, but the gold standard is still based on histological results (2,3). Lipoma of the thymus is an extremely rare and slow-growing benign tumor, mostly originating from the anterior mediastinum (4).…”

Section: Introductionmentioning

confidence: 99%