Welsh Onion Attenuates Hyperlipidemia in Rats Fed on High-Fat High-Sucrose Diet

Yamamoto, Yoshiyuki; Yasuoka, Ayumi

doi:10.1271/bbb.90613

Cited by 18 publications

(15 citation statements)

References 17 publications

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“…In contrast, the white fibrous root is usually discarded. The edible portion of Welsh onion has been reported to show hypolipidemic [12] and antioxidant effects in rats fed a high-fat, high sucrose diet [13]. Dyslipidemia is one characteristic of diabetes [14], and hyperglycemia in diabetes leads to increase oxidative stress, which plays an important role in the progression of diabetes [15,16].…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic effects of Welsh onion in an animal model of diabetes mellitus

et al. 2010

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Tight control of blood glucose is the most important strategy for the treatment of diabetes mellitus. Here, we investigated the beneficial effects of Welsh onion on fasting and postprandial hyperglycemia. Inhibitory activities of hot water extracts from the green stalk and white bulb, which are the edible portions of the Welsh onion, and the fibrous root extract against yeast α-glucosidase were measured in vitro. To study the effects of Welsh onion on postprandial hyperglycemia, a starch solution (1 g/kg) with and without Welsh onion fibrous root extract (500 mg/kg) or acarbose (50 mg/kg) was administered to streptozotocin-induced diabetic rats after an overnight fast. Postprandial plasma glucose levels were measured and incremental areas under the response curve were calculated. To study the hypoglycemic effects of chronic feeding of Welsh onion, five-week-old db/db mice were fed an AIN-93G diet or a diet containing either Welsh onion fibrous root extract at 0.5% or acarbose at 0.05% for 7 weeks after 1 week of adaptation. Fasting plasma glucose and blood glycated hemoglobin were measured. Compared to the extract from the edible portions of Welsh onion, the fibrous root extract showed stronger inhibition against yeast α-glucosidase, with an IC50 of 239 µg/mL. Oral administration of Welsh onion fibrous root extract (500 mg/kg) and acarbose (50 mg/kg) significantly decreased incremental plasma glucose levels 30-120 min after oral ingestion of starch as well as the area under the postprandial glucose response curve, compared to the control group (P < 0.01). The plasma glucose and blood glycated hemoglobin levels of the Welsh onion group were significantly lower than those of the control group (P < 0.01), and were not significantly different from those fed acarbose. Thus, we conclude that the fibrous root of Welsh onion is effective in controlling hyperglycemia in animal models of diabetes mellitus.

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Section: Introductionmentioning

confidence: 99%

Hypoglycemic effects of Welsh onion in an animal model of diabetes mellitus

et al. 2010

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“…There have been many reports on the hypolipidemic effects of Allium species. Yamamoto (2010) reported that welsh onion attenuates hyperlipidemia in rats fed on a high-fat high-sucrose diet [ 18 ]. Also, extracts of garlic, which is another Allium crop, have also been reported to lower plasma lipids in rats fed on a diet with or without cholesterol [ 42 43 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, A. fistulosum has been traditionally applied to treat common colds, headache, abdominal pain, and cardiovascular disease [ 15 ]. Previously, researchers have reported that A. fistulosum also exhibits antiplatelet, anti-oxidative, anti-hypertensive, and anti-hyperlipidemic effects [ 16 17 18 ], and other members of the Allium family have been reported to have inhibitory activity against pathogenic bacteria, fungi, mycotoxins, and putrefactive bacteria [ 19 ]. A recent study described the anti-obesity effect of an A. fistulosum extract [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Ethanol extract of Allium fistulosum inhibits development of non-alcoholic fatty liver disease

et al. 2018

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BACKGROUND/OBJECTIVESNon-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is closely associated with metabolic syndrome. In the present study, we observed the effect of ethanol extract of Allium fistulosum (EAF) on NAFLD and have suggested the possibility of using EAF as a natural product for application in the development of a treatment for NAFLD.MATERIALS/METHODSThe preventive effect on hepatic lipid accumulation was estimated by using an oleic acid (OA)-induced NAFLD model in vitro and a Western diet (high-fat high-sucrose; WD)-induced obese mouse model. Animals were divided into three groups (n = 7): normal diet group (ND), WD group, and WD plus 1% EAF group.RESULTSEAF reduced OA-stimulated lipid accumulation in HepG2 cells in the absence of cellular cytotoxicity and significantly blocked transcriptional activation of sterol regulatory element-binding protein 1 and fatty acid synthase genes. Subsequently, we investigated these effects in vivo in mice fed either ND or WD in the presence or absence of EAF supplementation. In comparison to the ND controls, the WD-fed mice exhibited increases in body weight, liver weight, epididymal fat weight, and accumulation of fat in hepatocytes, and these effects were significantly attenuated by EAF supplementation.CONCLUSIONSAllium fistulosum attenuates the development of NAFLD, and EAF elicits anti-lipogenic activity in liver. Therefore, EAF represents a promising candidate for use in the development of novel therapeutic drugs or drug combinations for the prevention and treatment of NAFLD.

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“…A. fistulosum also has been traditionally used to treat common colds, headache, abdominal pain, and cardiovascular disease [ 1 ]. Several studies have indicated that A. fistulosum has anti-platelet, anti-oxidative, anti-hypertensive, and anti-hyperlipidemic properties [ 2 – 4 ]. Viola mandshurica (Commonly known as violet), a perennial herb in the Violaceae family, is a traditional herbal medicine with expectorant, diuretic, and anti-inflammatory effects [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

The nutritional composition and anti-obesity effects of an herbal mixed extract containing Allium fistulosum and Viola mandshurica in high-fat-diet-induced obese mice

Sung

Kim

Yoo

et al. 2015

BMC Complement Altern Med

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BackgroundIn traditional oriental medicine, A. fistulosum and V. mandshurica are considered to be effective in promoting blood circulation. Therefore, in this study, we investigated whether a solution containing both A. fistulosum and V. mandshurica (AFE + VME) extracts has synergistic effects on the treatment of hyperlipidemia and obesity.MethodsAnti-obesity effects of an herbal extract containing Allium fistulosum and Viola mandshurica (AFE + VME) were investigated in high-fat diet (HFD)-induced obese mice. AFE + VME was orally administrated to mice with the HFD at a dose of 200 mg/kg/day for 8 weeks. We observed the effects of mixed extract on body weight, fat mass, serum lipid levels, and mRNA expression levels of lipid metabolism-related genes in the adipose tissue of mice.ResultsThe nutritional analysis revealed that this mixed extract is high in carbohydrate (72.2 g/100 g) and protein (11.5 g/100 g); low in fat (1.7 g/100 g); rich in vitamins E (4.8 mg/100 g), B1 (14.8 mg/100 g), B2 (1.0 mg/100 g), niacin (7.9 mg/100 g), and folic acid (1.57 mg/100 g); and rich in minerals such as calcium (600 mg/100 g), iron (106.1 mg/100 g), and zinc (5.8 mg/100 g). The oral administration of AFE + VME in obese mice reduced body weight, tissue weight, adipocyte size, and lipid accumulation in the liver compared with HFD control mice. AFE + VME also decreased serum triglyceride, total cholesterol, and leptin concentrations. Furthermore, AFE + VME markedly increased the mRNA expression of peroxisome proliferator-activated receptor-γ (PPAR-γ), uncoupling protein-2 (UCP-2), and adiponectin and decreased leptin expression in the epididymal white adipose tissue. Our results suggest that the extract containing A. fistulosum and V. mandshurica improved lipid metabolism via the up-regulation of PPAR-γ, UCP-2, and adiponectin expression and the down-regulation of leptin in HFD-induced obese mice.ConclusionsTherefore, the extract containing Allium fistulosum and Viola mandshurica may be a potentially effective therapy for obesity and its related metabolic disorders such as hyperlipidemia and insulin resistance.

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Welsh Onion Attenuates Hyperlipidemia in Rats Fed on High-Fat High-Sucrose Diet

Cited by 18 publications

References 17 publications

Hypoglycemic effects of Welsh onion in an animal model of diabetes mellitus

Hypoglycemic effects of Welsh onion in an animal model of diabetes mellitus

Ethanol extract of Allium fistulosum inhibits development of non-alcoholic fatty liver disease

The nutritional composition and anti-obesity effects of an herbal mixed extract containing Allium fistulosum and Viola mandshurica in high-fat-diet-induced obese mice

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