Wen‐Dan Decoction Improves Negative Emotions in Sleep‐Deprived Rats by Regulating Orexin‐A and Leptin Expression

Wu, Fengzhi; Song, Yuehan; Feng, Linyin; He, Xin; Ma, Jie; Feng, Ting; Guan, Binghe; Wang, Liye; Li, Sinai; Liu, Xiaolan; Liu, Yan; Mao, Meng; Liu, Jing; Bai, Shijing; Song, Cai

doi:10.1155/2014/872547

Cited by 17 publications

(17 citation statements)

References 23 publications

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“…Furthermore, WDD has been widely applied in psychological medicine and stroke (Wu et al, 1999;Gao, 2000;Chun et al, 2003). Recently, WDD treatment normalized the behavior and up-regulated orexin-A, leptin, orexin receptor 1 and leptin receptor in the brain (Wu et al, 2014). All these findings indicate the important roles of psychological factors in digestive disorders.…”

Section: Discussionmentioning

confidence: 78%

Consistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders

Wei

Huang

et al. 2015

Am. J. Chin. Med.

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Gastroesophageal reflux disease (GERD) and bile reflux gastritis (BRG) are common gastrointestinal (GI) disorders with unmet medical needs. Traditional Chinese medicine has long been used for the treatment of GERD and BRG whereas the ginger-containing formula Wendan decoction (WDD) targets homeostatic disturbances characterized by "reflux" and "gut-juice exposure" problems. Here we used WDD as a therapeutic tool to unravel the common pathogenesis of GI reflux disorders. Control clinical trials reporting the WDD-treated patients with GERD and BRG were included in this systematic review and meta-analysis. Outcome measurements were clinical efficacy defined by symptom relief with normal GI endoscopy, radiology, and pathology. Eventually, 33 studies involved 3253 participants (1351 vs. 1035 of the BRG in 20 publications, 449 vs. 418 of the GERD in 13 studies, and 194 vs. 159 of relapse rate in 6 trials). Pooled data showed a consistent therapeutic efficacy of WDD on BRG (OR = 6.00, 95%C = 4.68-7.69) and GERD (OR = 4.39, 95%CI = 2.72-7.07). The relapse rate was 12.4% for WDD, significantly lower than 44.0% for conventional therapies (OR = 0.14, 95%CI = 0.08-0.26). The consistent therapeutic efficacy of the single TCM formula on GERD and BRD indirectly indicates reflux as a common pathogenesis in reflux-associated GI disorders.

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Section: Discussionmentioning

confidence: 78%

Consistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders

Wei

Huang

et al. 2015

Am. J. Chin. Med.

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“…Increased levels of hcrt-1 in humans have been found during social interactions and in connection with social-induced positive emotions [ 11 ]. Indeed, hcrt neurons receive abundant input from the limbic system [ 33 ] and several papers have provided experimental evidence for an involvement of the hcrt system in emotion and emotional memory [ 28 , 34 , 35 ]. It is often speculated that that activation of hcrt neurons by the limbic system maintains wakefulness during emotional arousal.…”

Section: Discussionmentioning

confidence: 99%

Cerebrospinal Fluid Hypocretin-1 (Orexin-A) Level Fluctuates with Season and Correlates with Day Length

et al. 2016

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The hypocretin/orexin neuropeptides (hcrt) are key players in the control of sleep and wakefulness evidenced by the fact that lack of hcrt leads to the sleep disorder Narcolepsy Type 1. Sleep disturbances are common in mood disorders, and hcrt has been suggested to be poorly regulated in depressed subjects. To study seasonal variation in hcrt levels, we obtained data on hcrt-1 levels in the cerebrospinal fluid (CSF) from 227 human individuals evaluated for central hypersomnias at a Danish sleep center. The samples were taken over a 4 year timespan, and obtained in the morning hours, thus avoiding impact of the diurnal hcrt variation. Hcrt-1 concentration was determined in a standardized radioimmunoassay. Using biometric data and sleep parameters, a multivariate regression analysis was performed. We found that the average monthly CSF hcrt-1 levels varied significantly across the seasons following a sine wave with its peak in the summer (June—July). The amplitude was 19.9 pg hcrt/mL [12.8–26.9] corresponding to a 10.6% increase in midsummer compared to winter. Factors found to significantly predict the hcrt-1 values were day length, presence of snow, and proximity to the Christmas holiday season. The hcrt-1 values from January were much higher than predicted from the model, suggestive of additional factors influencing the CSF hcrt-1 levels such as social interaction. This study provides evidence that human CSF hcrt-1 levels vary with season, correlating with day length. This finding could have implications for the understanding of winter tiredness, fatigue, and seasonal affective disorder. This is the first time a seasonal variation of hcrt-1 levels has been shown, demonstrating that the hcrt system is, like other neurotransmitter systems, subjected to long term modulation.

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“…At present, adjuvant drugs for SD play a role in the central nervous system, such as amphetamine, caffeine, and modafinil [ 13 ]. These medications are often associated with a number of side effects, including excessive sleepiness, thought disorders, nocturnal wandering, agitation, and balance problems, thereby limiting clinical use [ 14 ]. Ginseng roots ( Panax ginseng C. A Meyer), one of the best known traditional Chinese medicine (TCM) herbs, have been reported to display adaptogenic effects in the endocrine, immune, cardiovascular, and central nervous systems [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment

Gou

Cen

Fan

et al. 2017

International Journal of Genomics

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Sleep loss or sleep deprivation (SD) refers to shorter sleep than average baseline need, and SD has been a serious problem of modern societies which affects health and well-being. Panax ginseng is a well-known traditional Chinese medicine (TCM). Our previous study has demonstrated that total ginsenosides (GS), the extracts from Panax ginseng, could effectively improve cognition and behavior on SD rats. However, little is known about its metabolomic study. In this study, serum and brain metabolomic method based on gas chromatography coupled with mass spectrometry (GC/MS) was employed to evaluate the efficacy and study the mechanism of GS on a rat model of SD. With pattern recognition analysis of serum and brain tissue metabolite profile, a clear separation of the model group and control group was acquired for serum and brain tissue samples; the MGS (model + GS) group showed a tendency of recovering when compared to control group, which was consistent with behavioral and biochemical parameters. 39 and 40 potential biomarkers of brain tissues and serum samples, respectively, were identified and employed to explore the possible mechanism. Our work revealed that GS has significant protective effects on SD, and metabolomics is a useful tool for evaluating efficacy and elucidating mechanism in TCM.

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Wen‐Dan Decoction Improves Negative Emotions in Sleep‐Deprived Rats by Regulating Orexin‐A and Leptin Expression

Cited by 17 publications

References 23 publications

Consistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders

Consistent Efficacy of Wendan Decoction for the Treatment of Digestive Reflux Disorders

Cerebrospinal Fluid Hypocretin-1 (Orexin-A) Level Fluctuates with Season and Correlates with Day Length

Serum and Brain Metabolomic Variations Reveal Perturbation of Sleep Deprivation on Rats and Ameliorate Effect of Total Ginsenoside Treatment

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