Wet adhesive hydrogel cardiac patch loaded with anti-oxidative, autophagy-regulating molecule capsules and MSCs for restoring infarcted myocardium

Wu, Tengling; Zhang, Xiaoping; Liu, Yang; Cui, Chunyan; Sun, Yage; Liu, Wenguang

doi:10.1016/j.bioactmat.2022.07.029

Cited by 41 publications

(23 citation statements)

References 45 publications

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“…In addition, wounds do not only exist on the external skin surface, and the application of antibacterial hydrogel wound dressings to organ wounds still requires more attention. The researchers have investigated cardiac patches [ [260] , [261] , [262] ] and abdominal wall patches [ [263] , [264] , [265] ], but the injected antibacterial hydrogel wound dressings for organs should be emphasized. Big data provides samples for the development of new antibacterial materials.…”

Section: Discussionmentioning

confidence: 99%

Recent progress of antibacterial hydrogels in wound dressings

Jia¹,

Li²,

Cao³

et al. 2023

Materials Today Bio

108

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Section: Discussionmentioning

confidence: 99%

Recent progress of antibacterial hydrogels in wound dressings

Jia¹,

Li²,

Cao³

et al. 2023

Materials Today Bio

108

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“…MSC can improve ventricular remodeling by stimulating angiogenesis, and promoting endogenous stem cell proliferation and cardiomyogenesis (Hatzistergos et al, 2010; Karantalis & Hare, 2015; Liu et al, 2017; Miyahara et al, 2006; Wu et al, 2023). Studies have found that compared with MSCs derived from bone marrow and umbilical cord, chorion‐derived MSCs (c‐MSCs) contribute more to the recovery of cardiac function and reduction of fibrosis after MI.…”

Section: Cell Therapy For Heart Regenerationmentioning

confidence: 99%

The origin, progress, and application of cell‐based cardiac regeneration therapy

Zhuo

Lei

et al. 2023

Journal Cellular Physiology

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Cardiovascular disease (CVD) has become a severe threat to human health, with morbidity and mortality increasing yearly and gradually becoming younger. When the disease progresses to the middle and late stages, the loss of a large number of cardiomyocytes is irreparable to the body itself, and clinical drug therapy and mechanical support therapy cannot reverse the development of the disease. To explore the source of regenerated myocardium in model animals with the ability of heart regeneration through lineage tracing and other methods, and develop a new alternative therapy for CVDs, namely cell therapy. It directly compensates for cardiomyocyte proliferation through adult stem cell differentiation or cell reprogramming, which indirectly promotes cardiomyocyte proliferation through non‐cardiomyocyte paracrine, to play a role in heart repair and regeneration. This review comprehensively summarizes the origin of newly generated cardiomyocytes, the research progress of cardiac regeneration based on cell therapy, the opportunity and development of cardiac regeneration in the context of bioengineering, and the clinical application of cell therapy in ischemic diseases.

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“…Furthermore, a wide variety of scaffolds with or without bioactive molecules have been used for cardiac regeneration. Wu et al developed a wet adhesive hydrogel cardiac patch loaded with antioxidative, autophagy-regulating molecule capsules, and MSCs [ 24 ]. The scaffold could improve the cardiac microenvironment and enhance the survival of transplanted stem cells by scavenging reactive oxygen species and upregulating autophagy, thus facilitating angiogenesis and reducing cardiac fibrosis to efficiently repair the infarcted myocardium [ 24 ].…”

Section: Engineered Cardiac Patch (Ecp) With Scaffoldmentioning

confidence: 99%

“…Wu et al developed a wet adhesive hydrogel cardiac patch loaded with antioxidative, autophagy-regulating molecule capsules, and MSCs [ 24 ]. The scaffold could improve the cardiac microenvironment and enhance the survival of transplanted stem cells by scavenging reactive oxygen species and upregulating autophagy, thus facilitating angiogenesis and reducing cardiac fibrosis to efficiently repair the infarcted myocardium [ 24 ]. Wang et al generated an ECP, using iPSC-derived CMs and decellularized natural heart ECM as scaffolds, which showed normal contractile and electrical physiology in vitro and improved cardiac function in a rat model of acute MI [ 25 ].…”

Section: Engineered Cardiac Patch (Ecp) With Scaffoldmentioning

confidence: 99%

Engineered Tissue for Cardiac Regeneration: Current Status and Future Perspectives

Liu

Zhang

et al. 2022

Bioengineering

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Heart failure (HF) is the leading cause of death worldwide. The most effective HF treatment is heart transplantation, the use of which is restricted by the limited supply of donor hearts. The human pluripotent stem cell (hPSC), including human embryonic stem cell (hESC) and the induced pluripotent stem cells (hiPSC), could be produced in an infinite manner and differentiated into cardiomyocytes (CMs) with high efficiency. The hPSC-CMs have, thus, offered a promising alternative for heart transplant. In this review, we introduce the tissue-engineering technologies for hPSC-CM, including the materials for cell culture and tissue formation, and the delivery means into the heart. The most recent progress in clinical application of hPSC-CMs is also introduced. In addition, the bottleneck limitations and future perspectives for clinical translation are further discussed.

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Wet adhesive hydrogel cardiac patch loaded with anti-oxidative, autophagy-regulating molecule capsules and MSCs for restoring infarcted myocardium

Cited by 41 publications

References 45 publications

Recent progress of antibacterial hydrogels in wound dressings

Recent progress of antibacterial hydrogels in wound dressings

The origin, progress, and application of cell‐based cardiac regeneration therapy

Engineered Tissue for Cardiac Regeneration: Current Status and Future Perspectives

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