What are the best outcome measurements for atopic eczema? A systematic review

Schmitt, Jochen; Langan, Sinéad; Williams, Hywel C

doi:10.1016/j.jaci.2007.08.011

Cited by 339 publications

(325 citation statements)

References 43 publications

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“…Bunlar arasında geçerlilik, güvenilirlik ve değişime yanıt yönünden valide edilen ve performansının iyi olduğu kabul edilen SCORAD indeksi (Severity Scoring of Atopic Dermatitis Index) çocuklarda klinik çalışmalarda ve günlük pratikte sık kullanılır (10).…”

Section: Introductionunclassified

Food Hypersensitivity in Atopic Dermatitis During Infancy: Skin Prick Testing for Whom?

Emeksiz

Cavkaytar

Aksoy

et al. 2017

Asthma Allergy Immunol

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ÖZGiriş: Atopik dermatit (AD) bebeklik döneminde sık görülen bir hastalıktır. Yaşamın ilk 6 ayında, özellikle ilk 3 ayında başvuran AD'li hastalarda besin duyarlılığı konusunda veri kısıtlıdır. Çalışmada AD tanısı almış bebeklerde başvuru zamanına göre besin duyarlılığı(BD) sıklığının ve ilişkili faktörlerin ortaya konulması amaçlanmıştır.Gereç ve Yöntem: Çalışmamıza S.B. Ankara Eğitim Araştırma Hastanesi Çocuk Allerji ve İmmünoloji Kliniği'ne başvuran AD'li bir yaşından küçük hastalar dahil edildi. Hastaların demografik özellikleri, beslenme durumları, hastalık şiddetleri, deri testi sonuçları kaydedildi. Besin duyarlılığı tanısı varlığında besin deri testi pozitifliği ile kondu. Deri testi pozitif olan hastaların tümü ilgili besinin diyetten eliminasyonundan fayda gördü. Bulgular: Çalışmaya 110 (%70'i erkek) hasta alındı, 23 (%21.6) bebek BD tanısı aldı. Üç aylık ve daha küçük AD'li hastalarda BD olanlarda olmayanlara göre SCORAD indeksi [(25.2 (20.9-34.9 Sonuç: Üç aylık ve daha küçük AD'li bebeklerde serum total IgE düzeyi ve SCORAD indeksi, 3-6 ay arasında ise ek olarak eozinofil ABSTRACT Objective: Atopic dermatitis (AD) is a common disease during infancy. The data on food hypersensitivity (FH) in the first six months and especially in the first three months of life is limited in children with AD. The aim of this study was to find out the frequency of FH and related factors in infants with AD in regard to their referral age. Materials and Methods:Infants younger than 1 years of age who were diagnosed as AD at the Ankara Training and Research Hospital's Department of Pediatrics were included in our study. The demographic features, nutritional status, disease severity and skin test results were recorded. A diagnosis of FH was made in the presence of a positive skin test with the related allergen. All the patients with FH had resolution of the symptoms with the elimination of the relevant food from the diet.Results: One-hundred and ten patients (70% male) were included. In patients younger than 3 months of age, the SCORAD-index and total IgE levels were higher in the patients with FH compared to patients without FH [(25.2(20.9-34.9) vs. 19.2(13.1-24.2), (p=0.034) and 22.2(11.6-52.6)kU/L vs. 4(4-10)kU/L, (p=0.04), respectively]. In patients aged between 3 and 6 months of age, the SCORAD index, total IgE and eosinophil levels were higher in patients with FH compared to patients without .7), (p<0.001)], [42.1(6.3-283)kU/L vs. 8.3(4.8-8.3)kU/L, (p=0.033)], [7.5%(3.9-9.7) vs. 3.5%(1.8-5.8), (p=0.01)]. In patients older than 6 months of age, the SCORAD index, eosinophil and IgE levels were similar between patients with and without FH.

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Section: Introductionunclassified

Food Hypersensitivity in Atopic Dermatitis During Infancy: Skin Prick Testing for Whom?

Emeksiz

Cavkaytar

Aksoy

et al. 2017

Asthma Allergy Immunol

View full text Add to dashboard Cite

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“…Przeprowadzono wiele badań nad walidacją tej skali i uznano ją za wiarygodne narzędzie zarówno w badaniach klinicznych, jak i w codziennej praktyce klinicznej [9,10,14,15]. SCORAD wykazuje wysoką korelację z ogólną oceną nasilenia choroby [10] oraz EASI [9].…”

Section: Scoring Atopic Dermatitis Index (Scorad)unclassified

“…Investigators' Global Atopic Dermatitis Assessment), która określa nasilenie choroby od braku zmian do bardzo ciężkiego i zawiera szczegółowo opisane zasady, jak oceniać poszczególne objawy dla każdej z kategorii nasilenia choroby [23]. Skala ta nie jest powszechnie stosowana i potrzeba dalszych badań nad oceną jej wiarygodności [14].…”

Section: Investigators' Global Assessment (Iga)unclassified

Assessment of the severity of atopic dermatitis

Bożek¹,

Reich²

2016

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“…Although no previous studies have examined incident case definitions for eczema, our results are consistent with the larger problem of the lack of standardised disease outcome measures in eczema research. For example, Schmitt et al 175 found 20 different scoring systems for measuring the severity of eczema. Chamlin et al 78 found 30 different definitions for defining an individual as high risk for DOI: 10.3310/pgfar04180 PROGRAMME GRANTS FOR APPLIED RESEARCH 2016 VOL.…”

Section: Main Findingsmentioning

confidence: 99%

“…175,299 Because these instruments assess different aspects of AE in different ways, trials cannot be readily compared and meta-analyses are often not possible. Consequently, clinical decision-making is limited by a lack of standardisation and validation of outcome measures.…”

Section: Background To the Harmonising Outcome Measures For Eczema Prmentioning

confidence: 99%

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease

Kim

Batchelor

Bath‐Hextall

et al. 2016

Programme Grants Appl Res

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Programme Grants for Applied ResearchISSN 2050-4322 (Print) ISSN 2050-4330 (Online) This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full PGfAR archive is freely available to view online at www.journalslibrary.nihr.ac.uk/pgfar. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Programme Grants for Applied Research journalReports are published in Programme Grants for Applied Research (PGfAR) if (1) they have resulted from work for the PGfAR programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors. Programme Grants for Applied Research programmeThe Programme Grants for Applied Research (PGfAR) programme, part of the National Institute for Health Research (NIHR), was set up in 2006 to produce independent research findings that will have practical application for the benefit of patients and the NHS in the relatively near future. The Programme is managed by the NIHR Central Commissioning Facility (CCF) with strategic input from the Programme Director.The programme is a national response mode funding scheme that aims to provide evidence to improve health outcomes in England through promotion of health, prevention of ill health, and optimal disease management (including safety and quality), with particular emphasis on conditions causing significant disease burden.For more information about the PGfAR programme please visit the website: http://www.nihr.ac.uk/funding/programme-grants-forapplied-research.htm This reportThe research reported in this issue of the journal was funded by PGfAR as project number RP-PG-0407-10177. The contractual start date was in September 2008. The final report began editorial review in April 2014 and was accepted for publication in April 2016. As the funder, the PGfAR programme agreed the research questions and study designs in advance with the investigators. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The PGfAR editors and production house have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the final report document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, CCF, NETSCC, PGfAR or the Department of Health. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, ...

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What are the best outcome measurements for atopic eczema? A systematic review

Cited by 339 publications

References 43 publications

Food Hypersensitivity in Atopic Dermatitis During Infancy: Skin Prick Testing for Whom?

Food Hypersensitivity in Atopic Dermatitis During Infancy: Skin Prick Testing for Whom?

Assessment of the severity of atopic dermatitis

A programme of research to set priorities and reduce uncertainties for the prevention and treatment of skin disease

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