What Are the Changes and Burden Associated With COVID-19 in Diabetes Management and Delivery of the Diabetes Services?

Sadera, Rohan; Youssef, Joyce; Ramadan, Azza; Ahmed, Mohamed H.

doi:10.14740/jem699

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…Patients with diabetes tend to have more severe disease vulnerability with poor glycemic control, which has a negative impact on the immunological system and may lead to a high risk of infections and serious life-threatening chronic complications with worse outcomes when they test positive for COVID-19. 81 In-vitro animal studies have shown that when angiotensinconverting enzyme 2 (ACE2), the main receptor responsible for COVID-19, binds with SARS-CoV-2, this biological mechanism reduces adequate insulin secretion by damaging the function of the beta cells of pancreatic islets. 82 On the other hand, infection secondary to diabetic complications is also accompanied by a huge production of cytokines, causing cytokine storms, which may induce insulin resistance.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Novel Insight into the Cellular and Molecular Signaling Pathways of Costus speciosus in the Treatment of COVID-19: A Review

Lodh,

Chakraborty

2024

Nature Cell and Science

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The latest pandemic of coronavirus disease 2019 , caused by the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought upon the world an unparalleled challenge. Since its inception, scientists and researchers have come together to develop various forms of vaccines and efficient therapeutic agents. In addition, plant products have been considered safe, cost-effective, and reliable molecules capable of neutralizing various microorganisms, including viruses. In this review, research articles on natural products related to antiviral effects were searched from various databases, such as the Web of Science, Google Scholar, Medline, Scopus, and PubMed, until August 2021, using English keywords. Moreover, the effectiveness of a locally available plant called Costus speciosus and its natural extracts on SARS-CoV-2 is discussed, while also providing insight into the cellular and molecular pathways of its active components that are involved in viral suppression. However, the lack of information regarding the safety profile and dosage for diverse diseases is one of the limitations of Costus speciosus as a natural medicine that can also interfere with COVID-19 pathogenesis by inhibiting SARS-CoV-2 replication and entry into host cells. We also highlight the use of plants as possible therapeutic agents in the prevention and management of COVID-19.

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Section: Antidiabetic Activitymentioning

confidence: 99%

Novel Insight into the Cellular and Molecular Signaling Pathways of Costus speciosus in the Treatment of COVID-19: A Review

Lodh,

Chakraborty

2024

Nature Cell and Science

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Assessment of knowledge and challenges toward the use of subcutaneous self-injecting insulin among diabetes patients during COVID-19 pandemic in Saudi Arabia

Alshawwa¹,

Almass²,

Alotaibi³

et al. 2021

Saudi Pharmaceutical Journal

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Background The COVID-19 pandemic has revolutionized the delivery of chronic health care. For diabetic patients, maintaining regular contact with healthcare providers and visiting healthcare centers are crucial to patients’ overall ability to control their glycemic status. Objective To assess patients’ knowledge regarding the use of insulin injection devices and the challenges these patients face in obtaining medical advice, as well as to suggest alternative solutions for addressing these challenges among diabetic patients self-administering their injections during the COVID-19 pandemic. Methodology An observational cross-sectional study was conducted among a sample population (N = 178) of diabetic patients attending Security Forces Hospital–Riyadh, Saudi Arabia, from which the Institutional Review Board (IRB) was granted. Data was collected using a self-administered questionnaire, which was distributed from August to September 2020. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS) program (version 21). Significant P-value = < 0.05. Results The majority of patients had good knowledge and practice explained with values 73.6% of total papulation. Sixty-four percent of patients with type 1 diabetes and 59% of patients with type 2 diabetes reported experiencing moderately severe challenges obtaining counseling. There was no correlation between severity of disease and knowledge levels (p-value = 0.36). The most appropriate means of obtaining counseling was determined to be conversations with healthcare providers; this strategy received an overall average score of 4.9 ± 0.4 (p-value < 0.0001). Conclusion Regardless of whether knowledge is high among patients with diabetes, continuous support and counseling from healthcare providers is critical. The creation of innovative approaches to facilitate communication between diabetes patients and healthcare providers is recommended for continued patient care during the COVID-19 pandemic.

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What Are the Changes and Burden Associated With COVID-19 in Diabetes Management and Delivery of the Diabetes Services?

Cited by 2 publications

References 44 publications

Novel Insight into the Cellular and Molecular Signaling Pathways of Costus speciosus in the Treatment of COVID-19: A Review

Novel Insight into the Cellular and Molecular Signaling Pathways of Costus speciosus in the Treatment of COVID-19: A Review

Assessment of knowledge and challenges toward the use of subcutaneous self-injecting insulin among diabetes patients during COVID-19 pandemic in Saudi Arabia

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