What are the currently available and in development molecular markers for bladder cancer? Will they prove to be useful in the future?

Abdulmajed, Mohamed Ismat; Sancak, Eyüp Burak; Reşorlu, Berkan; Al-Chalaby, Gydhia Zuhair

doi:10.5152/tud.2014.60973

Cited by 3 publications

(3 citation statements)

References 46 publications

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“…Histopathologically, UUSUCs are generally high-grade tumors (9). Pathological tumor stage and histological grade are accepted as main indicators for prognosis similar to other malignant tumors (7,9,12,14,(19)(20)(21)(22)(23). Most of the cases were high-grade in our study.…”

Section: Discussionsupporting

confidence: 48%

“…There are many studies in the literature evaluating the factors affecting the prognosis of the UC but the data about the prognostic factors of UUSUC are limited (1,7,9,(12)(13)(14)(15)(16). In this study, we evaluated the effect of clinicopathological factors including age, sex, tumor grade, tumor stage, tumor necrosis, lymphovascular invasion (LVI), perineural invasion (PNI), lymph node metastasis (LNM), and distant metastasis on OS of UUSUC.…”

Section: Introductionmentioning

confidence: 99%

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8-armed octopus: Evaluation of clinicopathologic prognostic factors of urothelial carcinoma of the upper urinary system

Ekmekçi¹,

Küçük²,

Dere³

et al. 2019

Turk J Med Sci

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Background/aim: This study was designed to determine the characteristic features of upper urinary system urothelial carcinomas (UUSUCs) and to evaluate the clinicopathological parameters associated with prognosis. Materials and methods: A total of 74 cases of UUSUC were included, from three different centers. Demographic data and histopathological features such as tumor localization, concomitant tumor in the urinary system, distant metastasis with overall survival and disease-free survival obtained from the hospital records were evaluated retrospectively. Histopathologic prognostic features such as grade, perineural invasion, lymphovascular invasion, tumor necrosis, and surgical margin status were also evaluated. Results: Seventy cases (94.6%) underwent open nephroureterectomy whereas 4 cases (5.4%) had laparoscopic nefroureterectomy. Thirty-eight (51.4%) cases were located in the pelvis, 7 (9.5%) in the ureter, 29 (39.2%) both in the pelvis and ureter. Fifty-six (75.7%) cases were alive; however, 18 (24.3%) patients were found to be dead. pTa, pT1, pT2, pT3, and pT4 tumors were reported in 16 (21.6%), 13 (17.6%), 4 (5.4%), 28 (37.8%), and 13 (17.6%) patients, respectively. Histopathologically, 17 cases (23%) were low-grade, 57 cases (77%) were high-grade. Statistically significant correlation was observed between overall survival and lymph node metastasis, distant metastasis, tumor necrosis, and differentiation by univariate analysis. Only distant metastasis was statistically associated with overall survival by multivariate analysis. We found no significant relationship between disease-free survival and all parameters. Conclusions: Differentiation and necrosis of tumor, lymph node involvement, and presence of distant metastasis is associated with the overall survival of urothelial carcinoma of the upper urinary system.

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Section: Discussionsupporting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

8-armed octopus: Evaluation of clinicopathologic prognostic factors of urothelial carcinoma of the upper urinary system

Ekmekçi¹,

Küçük²,

Dere³

et al. 2019

Turk J Med Sci

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“…The initial evaluation of patients with high recurrence rate of bladder cancer contains: cystoscopy, clinical assessment of renal function, and imaging of the urinary tract, preferably with computed tomography (CT) or urography [7]. Cystoscopy and biopsy combination is a gold standard which allows to definitive diagnosis, staging, and implementing primary treatment [7,8].…”

Section: State Of Knowledge 21 the Follow Up Of Urinary Bladder Cancermentioning

confidence: 99%

Current prospects of urine cytology in diagnosis and follow-up urinary tract malignancies - the short review

Jarosz

Oszczędłowski

Pytka

et al. 2020

J Educ Health Sport

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Introduction and purpose: Cytology of urine sediment is a diagnostic tool used to screen for urinary tract lesions in two cases: surveillance of patients with a history of urothelial malignancies and patients with unexplained, new onset haematuria. Since 2015 histopathological laboratories have been able to report urine cytology according to The Paris System (TPS). Current studies suggest usefulness of urinary cytology in follow-up of urinary tract malignancies, especially urinary bladder cancer, which is the 13th most deadly throughout the world being responsible for 200 000 deaths in 2018 among neoplasms.Objective: To review currently available data on PubMed about usefulness urine cytology reporting in follow-up and diagnosis of urinary tract malignancies.A brief description of the state of knowledge: Advantages of urine cytology examination contain non-invasiveness, high specificity, lower cost than cystoscopy and enable immunohistochemistry performance as well. Implementation of The Paris System for reporting urine cytology has created an universally acceptable and globally used report system. Reporting according to TPS significantly reduced the number of cases described as atypical changes.Conclusions: Urinary cytology is used to supplement endoscopic evaluation of the urinary tract in the screening and the surveillance of urothelial carcinoma. The Paris System for reporting urinary cytology has clarified the diagnostic categories of urine sediment examination. Cystoscopy and urine cytology are the standard tools for monitoring urinary tract malignancies.

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Suppression of HBXIP Reduces Cell Proliferation, Migration and InvasionIn Vitro, and TumorigenesisIn Vivoin Human Urothelial Carcinoma of the Bladder

Li¹,

Liu

2016

Cancer Biotherapy and Radiopharmaceuticals

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Hepatitis B X-interacting protein (HBXIP) has been found overexpressed in several types of human cancer, however, the status of HBXIP expression in urothelial carcinoma of the bladder (UCB) has not been explored. In this study, the authors used real-time polymerase chain reaction and Western blot to test the expression of HBXIP in UCB and adjacent tissues. The expression of HBXIP was significantly increased in UCB tissues. In addition, they showed that suppression of HBXIP induced cell cycle arrest and increased cell apoptosis in T24 cells. Also, suppression of HBXIP also decreased T24 and PC3 cell proliferation, migration, and invasion. More importantly, the authors found that inhibition of HBXIP reduced the tumorigenesis in vivo, suggesting that HBXIP plays an important role in UCB progression. These data for the first time showed that HBXIP acts as an oncoprotein in UCB, suggesting that HBXIP may become a potential novel therapeutic target for the treatment of UCB.

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What are the currently available and in development molecular markers for bladder cancer? Will they prove to be useful in the future?

Cited by 3 publications

References 46 publications

8-armed octopus: Evaluation of clinicopathologic prognostic factors of urothelial carcinoma of the upper urinary system

8-armed octopus: Evaluation of clinicopathologic prognostic factors of urothelial carcinoma of the upper urinary system

Current prospects of urine cytology in diagnosis and follow-up urinary tract malignancies - the short review

Suppression of HBXIP Reduces Cell Proliferation, Migration and InvasionIn Vitro, and TumorigenesisIn Vivoin Human Urothelial Carcinoma of the Bladder

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