What characterizes event-free elderly FH patients? A comprehensive lipoprotein profiling

Melnes, Torunn; Bogsrud, Martin P.; Thorsen, Ida Kær; Fossum, Julie; Christensen, Jacob J.; Narverud, Ingunn; Retterstøl, Kjetil; Ulven, Stine Marie; Holven, Kirsten B.

doi:10.1016/j.numecd.2022.03.028

Cited by 6 publications

(1 citation statement)

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“…However, the underlying mechanisms behind HDL's protective role in atherogenesis remain undefined. To shed light on this matter, Melnes et al [20] analyzed the lipoprotein profile of those subjects free of cardiovascular events. In this study, the resilient older HeFH subjects had significantly higher levels of large and extra-large HDL cholesterol particles compared to the ACVD group.…”

Section: Discussionmentioning

confidence: 99%

Resilient Older Subjects with Heterozygous Familial Hypercholesterolemia, Baseline Differences and Associated Factors

Climent,

González-Guerrero,

Marco-Benedí

et al. 2024

IJMS

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Despite elevated low-density lipoprotein (LDL) cholesterol levels, some older subjects with heterozygous familial hypercholesterolemia (HeFH) do not develop atherosclerotic cardiovascular disease (ACVD) during their lifetime. The factors related to this resilient state have not been fully established. The aim of this study was to evaluate differential characteristics between older HeFH subjects with and without ACVD and factors associated with the presence of ACVD. Subjects were part of the Spanish Atherosclerosis Society Dyslipidemia Registry, and those ≥ 70 years old and with HeFH were included. Baseline characteristics of these subjects with and without ACVD were compared. A multivariate analysis was performed to assess factors associated with the presence of ACVD. A total of 2148 subjects with HeFH were included. Resilient subjects were mostly female, younger and presented fewer comorbidities with respect to the ACVD group. Subjects without ACVD had higher baseline high-density lipoprotein (HDL) cholesterol (55.8 ± 17.1 vs. 47.9 ± 15.4 mg/dL; p < 0.001) and lower lipoprotein(a) [Lp(a)] (53.4 ± 67.9 vs. 66.6 ± 85.6 mg/dL; p < 0.001) levels with respect to those in the ACVD group. Lp(a) and the presence of ≥3 risk factors were associated with the presence of ACVD.

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Section: Discussionmentioning

confidence: 99%