What defines the nervus terminalis? Neurochemical, developmental, and anatomical criteria

Wirsig‐Wiechmann, Celeste R.; Wiechmann, Allan F.; Eisthen, Heather L.

doi:10.1016/s0079-6123(02)41083-7

Cited by 62 publications

(53 citation statements)

References 83 publications

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“…Both of them will degenerates in fetal life [8]. The terminal nerve ganglion located in the subarachnoid space caudal to the olfactory bulb and the neurons spread diffusely to rest in the lamina cribrosa, nasal septum, nasal mucosa, Bowman's gland, naris mucosa, crista galli and hypopthalamus [9]. Persistance of these cells beyond fetal life may provide origin of ectopic esthesioneuroblastoma.…”

Section: Discussionmentioning

confidence: 99%

Ectopic Esthesioneuroblastoma of the Sphenoclivus: A Rare Entity

Zahedi

Gendeh

Husain

et al. 2016

Indian J Otolaryngol Head Neck Surg

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Esthesioneuroblastoma is a rare malignant neoplasm of oflactory neuroepithelium and usually located at the olfactory cleft at superior nasal cavity. Ectopic localization of esthesioneuroblastoma is even rarer and usually posed with a diagnostic dilemma and delay in the diagnosis and management, We report a rare case of ectopic esthesioneuroblastoma of the sphenoclivus with the presentation of intermittent unilateral epistaxis, intermittent intractable headache without anosmia. Nasal endoscopy findings showed a pulsatile mass at the anterior face of the sphenoid sinus with extension posteriorly towards the clivus region and occupying the floor of the sphenoid sinus. Endonasal transclival endoscopic excision of tumour was performed which involved otorhinolaryngology surgeon and neurosurgeon with intraoperative navigation imaging and frozen section. The histopathological findings was esthesioneuroblastoma. Due to its rarity and unusual presentation, the diagnosis of ectopic esthesioneuroblastoma is difficult and can be misdiagnosed with the other type of malignancy. Therefore, the histopathological result is important in confirming the type of tumour and can lead to the next step of management.

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Section: Discussionmentioning

confidence: 99%

Ectopic Esthesioneuroblastoma of the Sphenoclivus: A Rare Entity

Zahedi

Gendeh

Husain

et al. 2016

Indian J Otolaryngol Head Neck Surg

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“…This nerve is a "diffusely organized system of neurons" which emigrate from the olfactory placode and, in all jawed vertebrates, finally reside "within the nasal cavity and rostral forebrain" (Wirsig-Wiechmann et al, 2002). It runs in close vicinity to the main olfactory and vomeronasal nerves, contains compact ganglia, and also exists in humans (de Vries, 1905: cited in Larsell, 1950Brookover, 1914;Johnston, 1914).…”

Section: Terminal Nervementioning

confidence: 99%

“…It runs in close vicinity to the main olfactory and vomeronasal nerves, contains compact ganglia, and also exists in humans (de Vries, 1905: cited in Larsell, 1950Brookover, 1914;Johnston, 1914). Subpopulations of its neurons contain neuropeptides, among others gonadotropin-releasing hormone (GnRH), which modulate the activity of receptor cells (Wirsig-Wiechmann et al, 2002;Vilensky, 2014).…”

Section: Terminal Nervementioning

confidence: 99%

Early development of the nervous system of the eutherian <i>Tupaia belangeri</i>

Knabe¹,

Washausen²

2015

Primate Biol.

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Abstract. The longstanding debate on the taxonomic status of Tupaia belangeri (Tupaiidae, Scandentia, Mammalia) has persisted in times of molecular biology and genetics. But way beyond that Tupaia belangeri has turned out to be a valuable and widely accepted animal model for studies in neurobiology, stress research, and virology, among other topics. It is thus a privilege to have the opportunity to provide an overview on selected aspects of neural development and neuroanatomy in Tupaia belangeri on the occasion of this special issue dedicated to Hans-Jürg Kuhn. Firstly, emphasis will be given to the optic system. We report rather "unconventional" findings on the morphogenesis of photoreceptor cells, and on the presence of capillary-contacting neurons in the tree shrew retina. Thereafter, network formation among directionally selective retinal neurons and optic chiasm development are discussed. We then address the main and accessory olfactory systems, the terminal nerve, the pituitary gland, and the cerebellum of Tupaia belangeri. Finally, we demonstrate how innovative 3-D reconstruction techniques helped to decipher and interpret so-far-undescribed, strictly spatiotemporally regulated waves of apoptosis and proliferation which pass through the early developing forebrain and eyes, midbrain and hindbrain, and through the panplacodal primordium which gives rise to all ectodermal placodes. Based on examples, this paper additionally wants to show how findings gained from the reported projects have influenced current neuroembryological and, at least partly, medical research.

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“…Because of its anatomical projections, the nerve has been suggested to function as a chemosensory system (Rossi et al, 1972;Demski and Northcutt, 1983), although behavioral and electrophysiological studies have failed to demonstrate a sensory role (Bullock and Northcutt, 1984;Fujita et al, 1991;Wirsig-Wiechmann, 1993;White and Meredith, 1995). Instead, the terminal nerve probably serves a neuromodulatory function: its ganglion cells are rhythmically active (Oka, 1992(Oka, , 2002, and the undifferentiated fibers contain acetylcholine and potentially neuromodulatory peptides (Wirsig-Wiechmann et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Terminal Nerve-Derived Neuropeptide Y Modulates Physiological Responses in the Olfactory Epithelium of Hungry Axolotls (Ambystoma mexicanum)

et al. 2006

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The vertebrate brain actively regulates incoming sensory information, effectively filtering input and focusing attention toward environmental stimuli that are most relevant to the animal's behavioral context or physiological state. Such centrifugal modulation has been shown to play an important role in processing in the retina and cochlea, but has received relatively little attention in olfaction. The terminal nerve, a cranial nerve that extends underneath the lamina propria surrounding the olfactory epithelium, displays anatomical and neurochemical characteristics that suggest that it modulates activity in the olfactory epithelium. Using immunocytochemical techniques, we demonstrate that neuropeptide Y (NPY) is abundantly present in the terminal nerve in the axolotl (Ambystoma mexicanum), an aquatic salamander. Because NPY plays an important role in regulating appetite and hunger in many vertebrates, we investigated the possibility that NPY modulates activity in the olfactory epithelium in relation to the animal's hunger level. We therefore characterized the full-length NPY gene from axolotls to enable synthesis of authentic axolotl NPY for use in electrophysiological experiments. We find that axolotl NPY modulates olfactory epithelial responses evoked by L-glutamic acid, a food-related odorant, but only in hungry animals. Similarly, whole-cell patch-clamp recordings demonstrate that bath application of axolotl NPY enhances the magnitude of a tetrodotoxin-sensitive inward current, but only in hungry animals. These results suggest that expression or activity of NPY receptors in the olfactory epithelium may change with hunger level, and that terminal nerve-derived peptides modulate activity in the olfactory epithelium in response to an animal's changing behavioral and physiological circumstances.

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What defines the nervus terminalis? Neurochemical, developmental, and anatomical criteria

Cited by 62 publications

References 83 publications

Ectopic Esthesioneuroblastoma of the Sphenoclivus: A Rare Entity

Ectopic Esthesioneuroblastoma of the Sphenoclivus: A Rare Entity

Early development of the nervous system of the eutherian <i>Tupaia belangeri</i>

Terminal Nerve-Derived Neuropeptide Y Modulates Physiological Responses in the Olfactory Epithelium of Hungry Axolotls (Ambystoma mexicanum)

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What defines the nervus terminalis? Neurochemical, developmental, and anatomical criteria

Cited by 62 publications

References 83 publications

Ectopic Esthesioneuroblastoma of the Sphenoclivus: A Rare Entity

Ectopic Esthesioneuroblastoma of the Sphenoclivus: A Rare Entity

Early development of the nervous system of the eutherian &lt;i&gt;Tupaia belangeri&lt;/i&gt;

Terminal Nerve-Derived Neuropeptide Y Modulates Physiological Responses in the Olfactory Epithelium of Hungry Axolotls (Ambystoma mexicanum)

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Early development of the nervous system of the eutherian <i>Tupaia belangeri</i>