What do Cochrane systematic reviews say about congenital vascular anomalies and hemangiomas? A narrative review

Neto, Henrique Jorge Guedes; Kuramoto, Danielle Akemi Bergara; Correia, Rebeca; Santos, Brena Costa; Borges, Amanda da Cunha; Pereda, Mariana Raffo; Aidar, Ana Laura E Silva; Júnior, Francisco Amadeu Pereira; Amaral, Fabio Cabral de Freitas; Vasconcelos, Vladimir; Lustre, Wellington Gianoti; Amorim, Jorge Eduardo de; Flumignan, Ronald Luiz Gomes; Nakano, Luís Carlos Uta; Baptista-Silva, José Carlos Costa

doi:10.1590/1516-3180.2021.0374.r2.15092021

Cited by 4 publications

(2 citation statements)

References 20 publications

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“…Our observations seem consistent with the narrative review of Neto et al which aimed to summarize Cochrane systematic review evidence on treatments for congenital vascular anomalies and hemangiomas. They had several difficulties including the limited number of existing systematic reviews, limited number of participants in the studies of these pathologies and heterogeneity of the participants [ 126 ]. To carry out therapeutic clinical trials on rare superficial VAs, the results of our review suggest to select a design that can limit the required sample size as much as possible.…”

Section: Discussionmentioning

confidence: 99%

Designs used in published therapeutic studies of rare superficial vascular anomalies: a systematic literature search

Allemang-Trivalle,

Leducq,

Maruani

et al. 2023

BMC Med Res Methodol

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Background Rare superficial vascular anomalies represent a wide range of diseases. Their management is difficult given the broad spectrum and the lack of clinical trials assessing treatment efficacy. A randomized clinical trial of vascular anomalies is difficult because of the rarity of the diseases and is enhanced by the population of interest often being children. Therefore, suitable designs are needed. We conducted a methodological systematic literature search to identify designs implemented for investigating the treatment of rare superficial vascular anomalies. Methods We conducted a literature search on January 25, 2021, of the PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Embase, ClinicalTrials.gov and European Union Clinical Trials Register databases. This systematic methodological literature search was registered at the Prospective Register of Systematic Reviews (PROSPERO: CRD42021232449). Randomized and non-randomized studies were included if they met the following criteria: were prospective studies of rare superficial vascular anomaly therapies, dealt with humans (adults and children) and were published in English from 2000. We excluded case reports/case series reporting fewer than 10 patients, reviews, retrospective studies, animal studies, studies of systemic or common vascular anomalies and non-therapeutic studies. We did not assess risk of bias in the included studies because our review was a methodological one focused on the design used. The review provided a descriptive analysis of relevant features of eligible research studies. Results From 2046 articles identified, we included 97 studies (62 reports and 35 ongoing studies): 25 randomized controlled studies, 7 non-randomized comparative studies, 64 prospective cohorts and 1 case series. Among the 32 comparative studies included, 21 used a parallel-group design. The 11 other studies used different designs such as cross-over, randomized placebo phase, delayed-start, within-person, or challenge–dechallenge–rechallenge or used a historical control group or an observational run-in period. Conclusions Our systematic literature search highlights the lack of randomized control trials in superficial vascular anomalies due to the rarity of patients and their heterogeneity. New designs are emerging and can overcome the limitations of testing treatments in parallel groups.

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Section: Discussionmentioning

confidence: 99%

Designs used in published therapeutic studies of rare superficial vascular anomalies: a systematic literature search

Allemang-Trivalle,

Leducq,

Maruani

et al. 2023

BMC Med Res Methodol

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“…Por tratar-se de uma condição complexa e heterogênea, tanto em relação a apresentação clínica quanto em seu curso natural, os indivíduos acometidos por malformações vasculares na região da face podem apresentar grande envolvimento psicossocial (Guedes Neto, et al, 2022). Na cavidade oral, as malformações vasculares acometem principalmente lábios, língua, mucosa jugal e palato (Mandú, et al, 2013).…”

Section: Introductionunclassified

Escleroterapia Com Oleato De Monoetanolamina Para Manejo De Malformação Vascular Em Lábio Inferior: Relato De Caso

Santos,

Bello,

Costa

et al. 2024

Rev. Foco

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INTRODUÇÃO: Os lábios são uma área de grande sensibilidade podendo sofrer lesões que alteram sua forma, tamanho, coloração e aspecto, sendo uma delas as malformações vasculares. Elas são anomalias que afetam os vasos sanguíneos causando sintomas como inchaço, descoloração, dor, sangramento e deformidadesfaciais. O diagnóstico ocorre através de exame clínico, sendo imprescindível a realização da manobra semiotécnica de vitropressão. O tratamento depende do tamanho da lesão, sintomatologia e histórico da sua evolução, podendo incluir cirurgia, embolização, escleroterapia, laserterapia ou uma combinação dessas técnicas. OBJETIVO: O objetivo deste trabalho é relatar um caso clínico de uma paciente do sexo feminino, 52 anos de idade com queixa de lesão em lábio inferior. Ao exame clínico observou-se lesão arroxeada e ressecamento excessivo em lábio inferior com principal hipótese diagnóstica de uma malformação vascular. O tratamento de escolha para ocaso foi a escleroterapia com oleato de monoetanolamina 0,05g/ml, obtendo resultado efetivo após terceira sessão. CONCLUSÃO: Com a indicação e o tratamento de escleroterapia para a lesão de malformação vascular obtivemos melhora significativa e um resultado satisfatório funcional e estético, além de proporcionar uma boa aceitação pela paciente pois a técnica foi pouco invasiva e de baixo custo.

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The Use of Timolol for Wound Healing—A Review

Lyle,

Budhiraja,

Mehta

et al. 2024

Curr Derm Rep

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Purpose of Review In recent years, drug repurposing has gained traction as a method to accelerate the availability of effective treatments. This review focuses on timolol, originally a topical non-selective β-adrenergic antagonist used for increased intraocular pressure and glaucoma, and its emerging role in the wound healing landscape—a field that has been lacking in effective treatments for decades. Recent Findings Preclinical and clinical studies have highlighted timolol’s promise as a therapeutic option in wound healing. Its benefits are attributed to various mechanisms including improved re-epithelialization, modulation of inflammation, and wound maturation, in addition to its impacts microbial quorum sensing and virulence. However, existing research also points to the need for larger, more comprehensive clinical trials to determine optimal dosing, efficacy, and safety. Some such trials are presently underway. Summary Timolol presents a new avenue for wound healing therapies, overcoming limitations seen in current treatment options. This review outlines timolol’s historical context in wound care, elaborates on its pharmacological mechanisms, and assesses ongoing research to validate its therapeutic potential. Future studies are needed for more conclusive data on its efficacy and safety in wound management.

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What do Cochrane systematic reviews say about congenital vascular anomalies and hemangiomas? A narrative review

Cited by 4 publications

References 20 publications

Designs used in published therapeutic studies of rare superficial vascular anomalies: a systematic literature search

Designs used in published therapeutic studies of rare superficial vascular anomalies: a systematic literature search

Escleroterapia Com Oleato De Monoetanolamina Para Manejo De Malformação Vascular Em Lábio Inferior: Relato De Caso

The Use of Timolol for Wound Healing—A Review

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