What Do We Know Beyond Reliability in Voxel-Based Registration? Validation of the Accuracy of Regional Voxel-Based Registration (R-VBR) Techniques for Orthognathic Surgery Analysis

What is the angular accuracy of regional voxel-based registration for segmental Le Fort I and genioplasty osteotomies?

“…Using published data on the angular accuracy of non-segmental Le Fort I osteotomies 29 , a sample size calculation was performed using a power of 0.80 and alpha of 0.05. This yielded a target sample size of 8.…”

“…The data acquisition and processing was identical to that reported in previous studies by the present authors' group, and is summarized in Fig. 2 29,30 The raw preoperative CBCT for each subject was oriented in a standard fashion as described by dos Santos et al 31 and Borba et al 32 , and the reoriented volume was labeled T0. The raw postoperative volume (T1) was superimposed onto T0 at the cranial base.…”

“…In a recent series of studies, Han et al 29,30 analyzed the angular and linear accuracy of the regional voxelbased registration (R-VBR) technique without these confounders, and found high accuracy within 0.5°, and a 0.3 mm (single voxel) threshold for most regions of interest (ROI). However, these studies by Han et al only analyzed segments from non-segmental Le Fort I and bilateral sagittal split osteotomies (BSSO), and therefore the results cannot be extrapolated to other osteotomies that produce smaller jaw segments.…”

Virtual surgical analysis: long-term cone beam computed tomography stability assessment of segmental bimaxillary surgery

“…1,13,14,[19][20][21] The accuracy of the approach is inherently difficult to infer due to the lack of ground truth data. Recently, Han et al 35 addressed the question "What do we know beyond reliability in voxel-based registration?" by attempting to validate the accuracy of regional VBR for the analysis of orthognathic surgery.…”

“…The study showed excellent accuracy in terms of rotational measurements when using the maxilla, distal mandible, and the bilateral proximal mandibular segments as VOI for regional VBR. 35 However, the ground truth is arguable.…”