In the last decades, eucalypt plantations are expanding across the Brazilian savanna, one of the most frequently burned ecosystems in the world. Wildfires are one of the main threats to forest plantations, causing economic and environmental loss. Modeling wildfire occurrence provides a better understanding of the processes that drive fire activity. Furthermore, the use of spatially explicit models may promote more effective management strategies and support fire prevention policies. In this work, we assessed wildfire occurrence combining Random Forest (RF) algorithms and cluster analysis to predict and detect changes in the spatial pattern of ignition probability over time. The model was trained using several explanatory drivers related to fire ignition: accessibility, proximity to agricultural lands or human activities, among others. Specifically, we introduced the progression of eucalypt plantations on a two-year basis to capture the influence of land cover changes over fire likelihood consistently. Fire occurrences in the period 2010-2016 were retrieved from the Brazilian Institute of Space Research (INPE) database. In terms of the AUC (area under the Receiver Operating Characteristic curve), the model denoted fairly good predictive accuracy (AUC ≈ 0.72). Results suggested that fire occurrence was mainly linked to proximity agricultural and to urban interfaces. Eucalypt plantation contributed to increased wildfire likelihood and denoted fairly high importance as an explanatory variable (17% increase of Mean Square Error [MSE]). Nevertheless, agriculture and urban interfaces proved to be the main drivers, contributing to decreasing the RF's MSE in 42% and 38%, respectively. Furthermore, eucalypt plantations expansion is progressing over clusters of high wildfire likelihood, thus increasing the exposure to wildfire events for young eucalypt plantations and nearby areas. Protective measures should be focus on in the mapped Hot Spot zones in order to mitigate the exposure to fire events and to contribute for an efficient initial suppression rather than costly firefighting.The savanna is a very important biome due to its large geographic extent, high levels of biodiversity and intense fire activity [6,7], being among the most frequently burned ecosystems in the world [8,9]. At the same time, this fire-prone biome is perceived as favorable land for agricultural expansion, which has emerged as a key factor transformation for this region [10]. Recently, Brazilian savanna, also known as 'Cerrado', is experiencing a significant land use transformation, with the native vegetation being replaced by intensive forestry, agricultural lands and urban areas [11]. The probability of a fire to occur depends on the occurrence of an ignition source (either human-related or natural) and favorable burning conditions within the environment [12]. In the Brazilian savanna, fire is used by humans as a management tool for vegetation removal, maintain grasslands, burn off agricultural residues or clean farm borders [6,13]. Nonetheless, fi...