What have we learnt about rotavirus in Spain in the last 10 years?

Díez‐Domingo, Javier; Garcés-Sánchez, María; Giménez-Sánchez, Francisco; Colomina-Rodríguez, Javier; Martinón-Torres, Federico

doi:10.1016/j.anpede.2019.01.010

Cited by 10 publications

(19 citation statements)

References 47 publications

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“…Vaccines against RV have been shown to have an impact in reducing the hospitalizations due to RVGE in children < 5 years of age that seems to be highly dependent on the fulfilled vaccination coverage [ 13 , 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Both vaccines are indicated for immunization of infants from 6 weeks of age and the schedule must be completed before 24 or 32 weeks of age for Rotarix and RotaTeq, respectively. Because of the incidental finding of circovirus DNA contamination in both vaccines, the Spanish Medicine Agency suspended RV vaccine distribution temporarily, withdrawing RV5 from June 2010 to November 2010, and RV1 from February 2010 to June 2016 [ 13 ]. Since reintroduction after the 5 months suspension, VCR has steadily increased from 19% in 2010 to 52% in 2018.…”

Section: Introductionmentioning

confidence: 99%

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Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–2018

et al. 2021

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Background Rotavirus (RV) vaccines are available in Spain since 2006 but are not included in the National Immunization Program. RV vaccination has reached an intermediate vaccination coverage rate (VCR) but with substantial differences between provinces. The aim of this study was to assess the ratio of RV gastroenteritis (RVGE) admissions to all-cause hospitalizations in children under 5 years of age in areas with different VCR. Methods Observational, multicenter, cross-sectional, medical record-based study. All children admitted to the study hospitals with a RVGE confirmed diagnosis during a 5-year period were selected. The annual ratio of RVGE to the total number of all-cause hospitalizations in children < 5 years of age were calculated. The proportion of RVGE hospitalizations were compared in areas with low (< 30%), intermediate (31–59%) and high (> 60%) VCR. Results From June 2013 to May 2018, data from 1731 RVGE hospitalizations (16.47% of which were nosocomial) were collected from the 12 study hospitals. RVGE hospital admissions accounted for 2.82% (95 CI 2.72–3.00) and 43.84% (95% CI 40.53–47.21) of all-cause and Acute Gastroenteritis (AGE) hospitalizations in children under 5 years of age, respectively. The likelihood of hospitalization due to RVGE was 56% (IC95%, 51–61%) and 27% (IC95%, 18–35%) lower in areas with high and intermediate VCR, respectively, compared to the low VCR areas. Conclusions RVGE hospitalization ratios are highly dependent on the RV VCR. Increasing VCR in areas with intermediate and low coverage rates would significantly reduce the severe burden of RVGE that requires hospital management in Spain. Clinical trial registration Not applicable

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–2018

et al. 2021

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“…In Europe, RVA is responsible for 75,000-150,000 infantile hospitalization due to acute gastroenteritis associated with RVA infections. In Spain, the annual incidence of acute gastroenteritis associated with RVA in primary care ranges between 15.4 and 19.5 cases per 1000 children up to 5 years and 20 cases per 1000 children up to 3 years [2].…”

Section: Introductionmentioning

confidence: 99%

High Prevalence of Rotavirus A in Raw Sewage Samples from Northeast Spain

Silva‐Sales

Martínez-Puchol

Gonzales-Gustavson

et al. 2020

Viruses

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Rotavirus A (RVA) is the most common virus associated with infantile gastroenteritis worldwide, being a public health threat, as it is excreted in large amounts in stool and can persist in the environment for extended periods. In this study, we performed the detection of RVA and human adenovirus (HAdV) by TaqMan qPCR and assessed the circulation of RVA genotypes in three wastewater treatment plants (WWTPs) between 2015 and 2016 in Catalonia, Spain. RVA was detected in 90% and HAdV in 100% of the WWTP samples, with viral loads ranging between 3.96 × 104 and 3.30 × 108 RT-PCR Units/L and 9.51 × 104 and 1.16 × 106 genomic copies/L, respectively. RVA VP7 and VP4 gene analysis revealed the circulation of G2, G3, G9, G12, P[4], P[8], P[9] and P[10]. Nucleotide sequencing (VP6 fragment) showed the circulation of I1 and I2 genotypes, commonly associated with human, bovine and porcine strains. It is important to mention that the RVA strains isolated from the WWTPs were different from those recovered from piglets and calves living in the same area of single sampling in 2016. These data highlight the importance of monitoring water matrices for RVA epidemiology and may be a useful tool to evaluate and predict possible emergence/reemergence of uncommon strains in a region.

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“…There is no speci c DRG for RV, and a DRG including AGE and other miscellaneous digestive disorders in age < 18 years was mainly used. RV is known to cause more severe AGE than other pathogens, probably leading to longer hospital stays [7]. Therefore, the lack of a speci c GRD for RVGE may be responsible for an underestimation of RVGE hospitalization costs when using the DRG cost assignation.…”

Section: Discussionmentioning

confidence: 99%

“…They are use under pediatricians' recommendations and fully paid by parents, reaching an intermediate vaccination coverage rate with signi cant differences between regions. RV vaccines have demonstrated to be highly effective, achieving 60-90% reductions in outpatient visits, emergency room (ER) visits, and hospitalizations due to severe AGE in children in many Western European and, indirectly, days missed from work of parents [6][7][8][9]12].…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics, Health Care Resource Utilization and Direct Medical Costs of Rotavirus Hospitalizations in Spain (2013-2018)

Arı́stegui

Alfayate-Miguélez

Carazo-Gallego

et al. 2021

Preprint

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Background: Rotavirus (RV) is the most common cause of severe gastroenteritis (GE) in infants and young children worldwide and is associated with a significant clinical and economic burden. The objective of this study was to analyze the characteristics, healthcare resource utilization and the direct medical costs related to RVGE hospitalizations.Methods: An observational, multicenter, cross-sectional study was conducted from June 2013 to May 2018 at the pediatric departments of 12 hospitals from different Spanish regions. Children under 5 years of age admitted to the hospital with a confirmed diagnosis of RVGE were selected. Data on clinical characteristics, healthcare resource use and costs were collected from patient records and hospital databases.Results: Most children hospitalized for RVGE did not have any previous medical condition or chronic disease. Forty-seven percent had previously visited the ER, 27% had visited a primary care pediatrician, and 15% had received pharmacological treatment prior to hospital admission due to an RVGE episode. The average length of a hospital stay for RVGE was 5.6 days, and the mean medical costs of RVGE hospitalizations per episode ranged from 3,940€ to 4,100€. The highest direct medical cost was due to the hospital stay.Conclusion: This study shows a high burden of health resource utilization and costs related to the management of cases of RVGE requiring hospitalization. RV vaccination with high coverage rates should be considered to minimize the clinical and economic impacts of this disease on the health care system.

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What have we learnt about rotavirus in Spain in the last 10 years?

Cited by 10 publications

References 47 publications

Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–2018

Rotavirus gastroenteritis hospitalizations in provinces with different vaccination coverage rates in Spain, 2013–2018

High Prevalence of Rotavirus A in Raw Sewage Samples from Northeast Spain

Clinical Characteristics, Health Care Resource Utilization and Direct Medical Costs of Rotavirus Hospitalizations in Spain (2013-2018)

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