What Is the Developmental Potential of Mature Oocytes Derived From Rescue in-Vitro Maturation (Rivm)?

Shani, Adi Kuperman; Haham, Lilach Marom; Kuznyetsova, Iryna; Bashar, Siamak; Librach, Clifford

doi:10.1016/j.fertnstert.2021.07.490

Cited by 3 publications

(4 citation statements)

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“…Although it is uncertain which one of the two embryos implanted successfully and led to this singleton pregnancy, it should be noted that the embryo derived from IVM was slower in cleavage compared to the embryo derived from failed IVF and rescue ICSI. For patients with low numbers of mature MII oocytes at egg retrieval, rescue IVM may be an attractive approach to provide additional competent oocytes and embryos for transfer, maximizing the chances for pregnancy [15]. Although IVM appears to be associated with only a small amount of epigenetic variation in cord blood and placental tissue [16], it has been previously linked to early pregnancy loss [17].…”

Section: Discussionmentioning

confidence: 99%

Poland Syndrome in a Pregnancy From an Assisted Reproductive Technology (ART) Cycle With In Vitro Maturation (IVM) and Rescue Intracytoplasmic Sperm Injection (ICSI)

Petrogiannis,

Filippa

et al. 2024

Cureus

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Poland syndrome is a congenital anatomical anomaly, characterised by partial or total aplasia of one side of the body causing abnormalities affecting the chest, shoulder, and upper limb. The exact mechanism that leads to this syndrome is unknown, but an abnormality in the vasculature formation or interruption of the blood supply of the subscapular artery and its branches early in development may be the main cause. Depending on the underlying mechanism, the syndrome has several expressions with some hardly being detectable and others not even being compatible with life. Here, we present a case of pregnancy from an assisted reproductive technology (ART) cycle with in vitro maturation (IVM) and rescue intra cytoplasmic sperm injection (ICSI), which resulted in the in-utero death of the foetus. The subsequent necropsy revealed a variation of Poland syndrome.

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Section: Discussionmentioning

confidence: 99%

Poland Syndrome in a Pregnancy From an Assisted Reproductive Technology (ART) Cycle With In Vitro Maturation (IVM) and Rescue Intracytoplasmic Sperm Injection (ICSI)

Petrogiannis,

Filippa

et al. 2024

Cureus

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“…Others have also reported ovulation of immature MI oocytes in rats and mice that have undergone superovulation with eCG [32][33][34][35]. Exogenous FSH also impedes maturation of up to 50% of oocytes retrieved from women after COS FSH stimulation [36][37][38][39][40][41][42][43][44]. This study used a highly purified eCG preparation with little contamination by LH or other components (AF Parlow, personal communication).…”

Section: Gonadotropin Treatment Impedes Oocyte Maturation In Young An...mentioning

confidence: 97%

Gonadotropin elevation is ootoxic to ovulatory oocytes and inhibits oocyte maturation, and activin decoy receptor ActRIIB:Fc therapeutically restores maturation

Bernstein,

Mackenzie,

Chaffin

et al. 2024

Reprod Biol Endocrinol

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Background Elevated FSH often occurs in women of advanced maternal age (AMA, age ≥ 35) and in infertility patients undergoing controlled ovarian stimulation (COS). There is controversy on whether high endogenous FSH contributes to infertility and whether high exogenous FSH adversely impacts patient pregnancy rates. Methods The senescence-accelerated mouse-prone-8 (SAMP8) model of female reproductive aging was employed to assess the separate impacts of age and high FSH activity on the percentages (%) of viable and mature ovulated oocytes recovered after gonadotropin treatment. Young and midlife mice were treated with the FSH analog equine chorionic gonadotropin (eCG) to model both endogenous FSH elevation and exogenous FSH elevation. Previously we showed the activin inhibitor ActRIIB:Fc increases oocyte quality by preventing chromosome and spindle misalignments. Therefore, ActRIIB:Fc treatment was performed in an effort to increase % oocyte viability and % oocyte maturation. Results The high FSH activity of eCG is ootoxic to ovulatory oocytes, with greater decreases in % viable oocytes in midlife than young mice. High FSH activity of eCG potently inhibits oocyte maturation, decreasing the % of mature oocytes to similar degrees in young and midlife mice. ActRIIB:Fc treatment does not prevent eCG ootoxicity, but it restores most oocyte maturation impeded by eCG. Conclusions FSH ootoxicity to ovulatory oocytes and FSH maturation inhibition pose a paradox given the well-known pro-growth and pro-maturation activities of FSH in the earlier stages of oocyte growth. We propose the FOOT Hypothesis (“FSH OoToxicity Hypothesis), that FSH ootoxicity to ovulatory oocytes comprises a new driver of infertility and low pregnancy success rates in DOR women attempting spontaneous pregnancy and in COS/IUI patients, especially AMA women. We speculate that endogenous FSH elevation also contributes to reduced fecundity in these DOR and COS/IUI patients. Restoration of oocyte maturation by ActRIB:Fc suggests that activin suppresses oocyte maturation in vivo. This contrasts with prior studies showing activin A promotes oocyte maturation in vitro. Improved oocyte maturation with agents that decrease endogenous activin activity with high specificity may have therapeutic benefit for COS/IVF patients, COS/IUI patients, and DOR patients attempting spontaneous pregnancies.

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“…Excessive culture time extension can result in atresia, egg aging, and elevated genetic risks. In contrast, if the culture period is too brief, the timing of cytoplasmic and nuclear maturation may be thrown off, which could have an impact on the potential for subsequent development [19]. According to Wrenzycki et al, oocytes can only mature at the end of the developmental process.…”

Section: Culture Time On In Vitro Maturation Of Oocytesmentioning

confidence: 99%

“…To maintain their stability, free radicals compete for electrons in proteins, lipids, and DNA, leading to a chain reaction that damages cellular structures. When there is an imbalance in the intracellular redox state, high levels of ROS are produced, triggering detrimental effects [19][20].…”

Section: Ros and Oxidative Stressmentioning

confidence: 99%

Research on vitro oocyte maturation technology and factors affecting oocyte maturation

Wang

2024

Third International Conference on Biological Engineering and Medical Science (ICBioMed2023)

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The development of oocytes is a vital process in living organisms, playing a crucial role in both human and animal health. This review aims to provide an in-depth exploration of oocyte morphogenesis, growth phases, maturation, and factors influencing oocyte quality and fertilization capacity. At the same time, this research introduces IVM technology, and focuses on the influencing factors and solutions in the application process. Additionally, this paper delves into key regulatory factors, signaling pathways, as well as the latest research techniques and methodologies concerning female cell development. It not only provides solutions for female diseases such as infertility, but also provides advanced technical means for animal reproduction and breeding.

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What Is the Developmental Potential of Mature Oocytes Derived From Rescue in-Vitro Maturation (Rivm)?

Cited by 3 publications

References 0 publications

Poland Syndrome in a Pregnancy From an Assisted Reproductive Technology (ART) Cycle With In Vitro Maturation (IVM) and Rescue Intracytoplasmic Sperm Injection (ICSI)

Poland Syndrome in a Pregnancy From an Assisted Reproductive Technology (ART) Cycle With In Vitro Maturation (IVM) and Rescue Intracytoplasmic Sperm Injection (ICSI)

Gonadotropin elevation is ootoxic to ovulatory oocytes and inhibits oocyte maturation, and activin decoy receptor ActRIIB:Fc therapeutically restores maturation

Research on vitro oocyte maturation technology and factors affecting oocyte maturation

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