What Is the Negative Predictive Value of Urinary Tract Cytology

Khan, Reema; Hussain, Hamad; Pambuccian, Stefan; Wojcik, Eva M.; Barkan, Güliz A.

doi:10.1016/j.jasc.2015.09.049

Cited by 4 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The decision to perform a biopsy of an equivocal lesion is justified if the cytologic diagnosis is Suspicious for HGUC (SHGUC) or HGUC. A negative urine cytology coupled with a normal cystoscopy is quite specific and reassuring that a potentially lethal high-grade malignancy is most likely absent [28]. A diagnosis of a ‘positive' or ‘suspicious' urine cytology should be thoroughly investigated and followed closely, regardless of the cystoscopic findings [29].…”

Section: The Urologist's Perspectivementioning

confidence: 99%

The Paris System for Reporting Urinary Cytology: The Quest to Develop a Standardized Terminology

et al. 2016

View full text Add to dashboard Cite

The main purpose of urine cytology is to detect high-grade urothelial carcinoma (HGUC). With this principle in mind, The Paris System (TPS) Working Group, composed of cytopathologists, surgical pathologists, and urologists, has proposed and published a standardized reporting system that includes specific diagnostic categories and cytomorphologic criteria for the reliable diagnosis of HGUC. This paper outlines the essential elements of TPS and the process that led to the formation and rationale of the reporting system. The Paris System Working Group, organized at the 2013 International Congress of Cytology, conceived a standardized platform on which to base cytologic interpretation of urine samples. The widespread dissemination of this approach to cytologic examination and reporting of urologic samples and the scheme's universal acceptance by pathologists and urologists is critical for its success. For urologists, understanding the diagnostic criteria, their clinical implications, and the limitations of TPS is essential if they are to utilize urine cytology and noninvasive ancillary tests in a thoughtful and practical manner. This is the first international/inclusive attempt at standardizing urinary cytology. The success of TPS will depend on the pathology and urology communities working collectively to improve this seminal paradigm shift, and optimize the impact on patient care.

show abstract

Section: The Urologist's Perspectivementioning

confidence: 99%

The Paris System for Reporting Urinary Cytology: The Quest to Develop a Standardized Terminology

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Hence, this screening procedure is crucial for patients at higher hazard for bladder cancer (senior smoker males and vocational exposure). [ 2 ]…”

Section: Introductionmentioning

confidence: 99%

Cytospin performance when using Paris system for reporting urinary cytology

et al. 2022

View full text Add to dashboard Cite

Objectives: The Paris System (TPS) for Reporting Urine Cytology has significantly improved the approach to evaluating urine cytology. TPS criteria were defined mainly according to ThinPrep and SurePath preparations, as they are widely utilized. The objective of this study is to validate urine cytology interpretation according to the TPS classification using cytospin technique in relation to the gold slandered histology. Material and Methods: This retrospective study examined and analyzed 316 urine specimens from King Abdulaziz University Hospital between 2015 and 2020. Cytospin technique is performed for all cases. Slides were recategorized using TPS criteria, then compared with the original histology diagnosis. Results: According to the TPS, 108 cases were classified as 101 AUC (32%), 95 NEG (30%), 59 HGUC (18.7%), 31 SHGUC (9.8%), and 30 (9.5%) others. The computed sensitivity of cytospin in urine cytology was 94.7%, with 73.9% specificity, a positive predictive value of 85.6%, a negative predictive value of 89.5%, and overall accuracy of 86.8%. Conclusion: Urine cytology testing is considered to be a non-invasive and sensitive method to screen for urothelial carcinoma. TPS defined standards are reliable on cytospin prepared slides for reporting urine cytology.

show abstract